Drug Target Type Action Effects
ivermectin ?? toxicity in collie dogs
associated with
frameshift mutation and
premature stop codon in
MDR1a gene which
encodes P-glycoprotein
(MDR1) BBB transporter
removes drugs from
brain
ethanol ? ? Vd similar to total body ?
water (45L)
chloroquin ? ? Vd = 13,000L due to ?
e sequestration in fat
codeine Mu- agonist; pro- metabolised by Cyp2D6 treat pain
opioid R drug to morphine, but mostly
codeine-6-glucuronide by
glucuronidation, some to
norcodeine by Cyp3A4
ivermectin ?? toxicity in collie dogs
associated with
frameshift mutation and
premature stop codon in
MDR1a gene which
encodes P-glycoprotein
(MDR1) BBB transporter
removes drugs from
brain
ethanol ? ? Vd similar to total body ?
water (45L)
chloroquin ? ? Vd = 13,000L due to ?
e sequestration in fat
codeine Mu- agonist; pro- metabolised by Cyp2D6 treat pain
opioid R drug to morphine, but mostly
codeine-6-glucuronide by
glucuronidation, some to
norcodeine by Cyp3A4
