QUIZ QUESTIONS AND ANSWERS
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Thenmajornreasonnfornnotncrushingnansustainednreleasencapsulenisnthat,nifncrushed,nthencoatednbea
dsnofnthendrugsncouldnpossiblynresultnin:
onDisintegration
onToxicityn
onMalabsorption
onDeteriorationn-nCORRECTnANSWERSnonToxicity
Drugsnthatnhavenansignificantnfirstnpassneffect:
onMustnbengivennbynenteraln(oral)nroutenonly
onBypassnthenhepaticncirculation
onArenrapidlynmetabolizednbynthenlivernandnmaynhavenlittlenifnanyndesirednactionn
onArenconvertednbynthenliverntonmorenactiveninnfat-solublenformsn-
nCORRECTnANSWERSnonArenrapidlynmetabolizednbynthenlivernandnmaynhavenlittlenifnanyndesirednacti
on
WhennobtainingnandrugnhistorynfromnHarold,nhengivesnyounancompletenlistnofnhisnprescriptionnmedi
cations.nHendeniesntakingnanynotherndrugs,nbutnyounfindnthatnhenoccasionallyntakesnaspirinnfornhisna
rthritisnflare-ups.nThisnisnannexamplenof:
onHisnappropriatelynonlyntellingnyounaboutnhisnregularlynprescribednmedications
, onHisnhidingninformationnregardingnhisninappropriatenusenofnaspirinnfromnyou
onHisncommonnmisconceptionnthatnintermittentlyntakingnOTCnmedicationsnarennotnannimportantnp
artnofnhisndrugnhistoryn
onAncommonnmisusenofnOTCnaspirinn-
nCORRECTnANSWERSnonHisncommonnmisconceptionnthatnintermittentlyntakingnOTCnmedicationsnar
ennotnannimportantnpartnofnhisndrugnhistory
DrugsnthatnusenCYP3A4nisoenzymesnfornmetabolismnmay:
onInducenthenmetabolismnofnanotherndrug
onInhibitnthenmetabolismnofnanotherndrug
onBothnAnandnBn
onNeithernAnnornBn-nCORRECTnANSWERSnonBothnAnandnB
Antwentynfournyearnoldnmalenreceivednmultiplenfracturesninnanmotornvehiclenaccidentnthatnrequire
dnsignificantnamountsnofnopioidnmedicationntontreatnhisnpain.nHenisnatnrisknfornTypen____nADRnwhe
nnhennonlongernrequiresnthenopioids.
onA
onC
onEn
onGn-nCORRECTnANSWERSnonE
InfantsnandnyoungnchildrennarenatnhighernrisknofnADRsnduento:
onImmaturenrenalnfunctionninnschoolagenchildren
onLacknofnsafetynandnefficacynstudiesninnthenpediatricnpopulationn