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Ultimate ASCP BOC Practice Exam 2026 – Realistic Questions, Verified Answers, and Detailed Explanations for Medical Laboratory Board Certification Success

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Prepare thoroughly for the ASCP Board of Certification (BOC) exam with this comprehensive practice guide designed for medical laboratory professionals seeking certification success. This resource features realistic practice questions, fully verified answers, and clear explanations covering all essential laboratory topics, including hematology, microbiology, chemistry, immunology, molecular diagnostics, blood banking, and laboratory safety. Each question is structured to mirror the actual BOC exam format, helping you build confidence and strengthen your understanding of both theoretical concepts and practical lab applications. Updated to reflect the latest 2026 exam standards, this guide also provides strategies for effective time management and exam-taking, making it ideal for self-study, review, or reinforcement of coursework. By using this practice exam, you can improve accuracy, enhance retention of key concepts, and maximize your chances of passing the ASCP BOC exam on your first attempt.

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Uploaded on
January 8, 2026
Number of pages
10
Written in
2025/2026
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Exam (elaborations)
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ASCP BOC PRACTICE EXAM
1. CML vs. Leukemoid Reaction


Answer CML - decreased leukocyte alkaline phosphatase (LAP) Leukemoid Reaction -


increased LAP


2. Look-back


Answer The process for the identification and notification of recipients of blood components from prior


donations of who now test positive for HCV, HIV-1 and/or HIV-2.


3. External reference electrode used in ISE


Answer KCl


4. The serum glucose concentration of a diabetic patient undergoing a 2-hr GTT


should return to the baseline (fasting level) after minutes.


Answer 120

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, 5. Technical problems encountered during the collection of an amniotic fluid


specimen caused doubt as to whether the specimen was amniotic in origin.


Which procedure would best establish that the fluid is amniotic in origin?


Answer Crea-


tinine clearance


6. Oval fat bodies and fatty casts are characteristic urine sediment constituents


in patients with .


Answer Nephritic Syndrome


7. What are the 2 most common reasons for macrocytosis?


Answer B12 and Folate deficiency


8. Calculation for corrected WBC


Answer (WBC x 100)/(#nrbc + 100)
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