CHE 4342 CELL SIGNALING EXAM QUESTIONS AND ANSWERS
LATEST DOWNLOADED 2025/2026 A COMPLETE SOLUTION
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SUCCESS
What is calmodulin's motif - CORRECT ANSWERS 4 EF hand motifs linked by a seven
turn alpha helix. 2 globular domains bind 2 Ca2+ ions
What happens when 4Ca2+ binds calmodulin? - CORRECT ANSWERS The alpha helix
moves away from the active site and CaM kinase peptidase results in the active form
What kind of protein does RTK have? - CORRECT ANSWERS small g protein
The small g protein is homologous to which part of the big g protein - CORRECT
ANSWERS the alpha subunit
What is the general structure of RTK - CORRECT ANSWERS they span the membrane of
the cell and have a hormone receptor on the outside and a tyrosine kinase protein on the inside
What happens to the RTK after the ligand binds? - CORRECT ANSWERS it is dimerized
(however they are already dimerized in some pathways such as insulin) and the other dimer is
phosphorylated
What EC classification are protein phosphatases and what do they do in signaling pathways -
CORRECT ANSWERS EC 3, and they remove phosphate groups from receptors and
target proteins to often stop signaling cascades
True or false: the ligand brings the receptors together in RTK - CORRECT ANSWERS
FALSE it is dimerization
The adaptor proteins in RTK pathway have what domains - CORRECT ANSWERS SH2
and SH3
, CHE 4342 CELL SIGNALING EXAM QUESTIONS AND ANSWERS
LATEST DOWNLOADED 2025/2026 A COMPLETE SOLUTION
ALL ANSWERS 100% CORRECT DETAILED BEST GRADED A+ FOR
SUCCESS
What are the components of the SH2 domain - CORRECT ANSWERS has a specific P-TYR
sequence, has a site for binding AA side chain, binding pocket for phosphotyrosine, (plug in
model)
What is the domain(s) for RAS - CORRECT ANSWERS SH3 which has proline rich
polypeptides
What does Grb 2 do and what are its domain(s) - CORRECT ANSWERS SH2 and SH3
indirectly activates Ras
What does RAS activate - CORRECT ANSWERS it activates Rap which results in a
conformational change
What is the off signal for insulin signaling - CORRECT ANSWERS PTEN
What is the domain of PDK 1 - CORRECT ANSWERS PH domain
What happens when Akt binds to Bax - CORRECT ANSWERS it inhibits apoptosis
resulting in cancer
How does Akt impact FOXO - CORRECT ANSWERS it phosphorylates it resulting in cell
proliferation
How does Akt impact MTOR - CORRECT ANSWERS it activates it and results in protein
synthesis
LATEST DOWNLOADED 2025/2026 A COMPLETE SOLUTION
ALL ANSWERS 100% CORRECT DETAILED BEST GRADED A+ FOR
SUCCESS
What is calmodulin's motif - CORRECT ANSWERS 4 EF hand motifs linked by a seven
turn alpha helix. 2 globular domains bind 2 Ca2+ ions
What happens when 4Ca2+ binds calmodulin? - CORRECT ANSWERS The alpha helix
moves away from the active site and CaM kinase peptidase results in the active form
What kind of protein does RTK have? - CORRECT ANSWERS small g protein
The small g protein is homologous to which part of the big g protein - CORRECT
ANSWERS the alpha subunit
What is the general structure of RTK - CORRECT ANSWERS they span the membrane of
the cell and have a hormone receptor on the outside and a tyrosine kinase protein on the inside
What happens to the RTK after the ligand binds? - CORRECT ANSWERS it is dimerized
(however they are already dimerized in some pathways such as insulin) and the other dimer is
phosphorylated
What EC classification are protein phosphatases and what do they do in signaling pathways -
CORRECT ANSWERS EC 3, and they remove phosphate groups from receptors and
target proteins to often stop signaling cascades
True or false: the ligand brings the receptors together in RTK - CORRECT ANSWERS
FALSE it is dimerization
The adaptor proteins in RTK pathway have what domains - CORRECT ANSWERS SH2
and SH3
, CHE 4342 CELL SIGNALING EXAM QUESTIONS AND ANSWERS
LATEST DOWNLOADED 2025/2026 A COMPLETE SOLUTION
ALL ANSWERS 100% CORRECT DETAILED BEST GRADED A+ FOR
SUCCESS
What are the components of the SH2 domain - CORRECT ANSWERS has a specific P-TYR
sequence, has a site for binding AA side chain, binding pocket for phosphotyrosine, (plug in
model)
What is the domain(s) for RAS - CORRECT ANSWERS SH3 which has proline rich
polypeptides
What does Grb 2 do and what are its domain(s) - CORRECT ANSWERS SH2 and SH3
indirectly activates Ras
What does RAS activate - CORRECT ANSWERS it activates Rap which results in a
conformational change
What is the off signal for insulin signaling - CORRECT ANSWERS PTEN
What is the domain of PDK 1 - CORRECT ANSWERS PH domain
What happens when Akt binds to Bax - CORRECT ANSWERS it inhibits apoptosis
resulting in cancer
How does Akt impact FOXO - CORRECT ANSWERS it phosphorylates it resulting in cell
proliferation
How does Akt impact MTOR - CORRECT ANSWERS it activates it and results in protein
synthesis
