Important terms and exam questions to study for Pathophysiology of Heart
and Circulatory system, Vrije Universiteit Amsterdam (AB_1015)
Study these well, and you will be guaranteed to pass your exam!
c) The core consists of triglycerides and cholesteryl esters and the shell of
phospholipids andapolipoproteins. ---> What is the composition of a lipoprotein?
a) The core consists of phospholipids and cholesteryl esters and the shell of
triglycerides andapolipoproteins.
b) The core consists of phospholipids and apolipoproteins and the shell of
triglycerides andcholesterol.
c) The core consists of triglycerides and cholesteryl esters and the shell of
phospholipids andapolipoproteins.
d) The core consists of diglycerides and cholesterol and the shell of phospholipids
and sterols
a) LPL catalyzes the hydrolysis of triglycerides to release free fatty acids using the
cofactorapolipoprotein C2 (ApoC2). ---> What is the main function of lipoprotein
lipase (LPL) and which cofactor is essential for this?
a) LPL catalyzes the hydrolysis of triglycerides to release free fatty acids using the
cofactorapolipoprotein C2 (ApoC2).
b) LPL catalyzes the hydrolysis of triglycerides to release free fatty acids using the
cofactorapolipoprotein E (ApoE).
c) LPL transports triglycerides from the gut to the blood using the cofactor
apolipoprotein C2 (ApoC2).
d) LPL transports triglycerides from the gut to the blood using the cofactor
apolipoprotein E (ApoE).
b) Foam cells in the atherosclerotic plaque are macrophages filled with oxidized
HDL. ---> Which statement is not true regarding the development of an
atherosclerotic plaque?
a) Rupture of a fibrous plaque leads to the formation of a thrombus that can occlude
the bloodvessel.
b) Foam cells in the atherosclerotic plaque are macrophages filled with oxidized
HDL.
c) Inflammation is involved in the formation of the atherosclerosis plaque.
d) LDL can pass through the vessel wall and undergo oxidation in the intima.
, Capillaries. ---> Which blood vessels are most relevant for vascular permeability
and edema?
c) limiting permeability and inflammation. ---> An intact glycocalyx is important for:
a) promoting angiogenesis and cell migration.
b) stimulating tissue perfusion.
c) limiting permeability and inflammation.
d) promoting permeability and leukocyte adhesion.
d) the linkage of VE-cadherin to the actin cytoskeleton. ---> The function of VE
cadherin is to prevent edema. This function depends on:
a) the transport of VE-cadherin to the basal side of the endothelial cells.
b) the binding of VE-cadherin to Caveolin1.
c) the increase in the concentration of VE-cadherin on the plasma membrane after
stimulation withVEGF.
d) the linkage of VE-cadherin to the actin cytoskeleton.
tyrosine kinases. ---> Imatinib is an inhibitor of:
c) smooth muscle cells. ---> The diameter change in resistance arteries resulting
from an increase in sympathetic activity is mainly caused by changes in:
a) macrophages.
b) endothelial cells.
c) smooth muscle cells.
d) fibroblasts.
c) By measuring the vascular resistance during intracoronary infusion of
acetylcholine. ---> An obese man is referred to the cardiologist with signs and
symptoms of myocardial ischemia. Howcould endothelial function be evaluated in
this man?
a) By making an angiogram of the major coronary arteries, filling them with a
contrast fluid.
b) By measuring blood flow during intracoronary infusion of adenosine.
c) By measuring the vascular resistance during intracoronary infusion of
acetylcholine.
d) By determining the pulse wave velocity using the SphygmoCor device.
d) the SphygmoCor system. ---> he manufacturer of the new drug against type 2
diabetes, Sellwithgliftozine, wishes to assess whether the drug lowers augmentation.
This can be investigated by:
and Circulatory system, Vrije Universiteit Amsterdam (AB_1015)
Study these well, and you will be guaranteed to pass your exam!
c) The core consists of triglycerides and cholesteryl esters and the shell of
phospholipids andapolipoproteins. ---> What is the composition of a lipoprotein?
a) The core consists of phospholipids and cholesteryl esters and the shell of
triglycerides andapolipoproteins.
b) The core consists of phospholipids and apolipoproteins and the shell of
triglycerides andcholesterol.
c) The core consists of triglycerides and cholesteryl esters and the shell of
phospholipids andapolipoproteins.
d) The core consists of diglycerides and cholesterol and the shell of phospholipids
and sterols
a) LPL catalyzes the hydrolysis of triglycerides to release free fatty acids using the
cofactorapolipoprotein C2 (ApoC2). ---> What is the main function of lipoprotein
lipase (LPL) and which cofactor is essential for this?
a) LPL catalyzes the hydrolysis of triglycerides to release free fatty acids using the
cofactorapolipoprotein C2 (ApoC2).
b) LPL catalyzes the hydrolysis of triglycerides to release free fatty acids using the
cofactorapolipoprotein E (ApoE).
c) LPL transports triglycerides from the gut to the blood using the cofactor
apolipoprotein C2 (ApoC2).
d) LPL transports triglycerides from the gut to the blood using the cofactor
apolipoprotein E (ApoE).
b) Foam cells in the atherosclerotic plaque are macrophages filled with oxidized
HDL. ---> Which statement is not true regarding the development of an
atherosclerotic plaque?
a) Rupture of a fibrous plaque leads to the formation of a thrombus that can occlude
the bloodvessel.
b) Foam cells in the atherosclerotic plaque are macrophages filled with oxidized
HDL.
c) Inflammation is involved in the formation of the atherosclerosis plaque.
d) LDL can pass through the vessel wall and undergo oxidation in the intima.
, Capillaries. ---> Which blood vessels are most relevant for vascular permeability
and edema?
c) limiting permeability and inflammation. ---> An intact glycocalyx is important for:
a) promoting angiogenesis and cell migration.
b) stimulating tissue perfusion.
c) limiting permeability and inflammation.
d) promoting permeability and leukocyte adhesion.
d) the linkage of VE-cadherin to the actin cytoskeleton. ---> The function of VE
cadherin is to prevent edema. This function depends on:
a) the transport of VE-cadherin to the basal side of the endothelial cells.
b) the binding of VE-cadherin to Caveolin1.
c) the increase in the concentration of VE-cadherin on the plasma membrane after
stimulation withVEGF.
d) the linkage of VE-cadherin to the actin cytoskeleton.
tyrosine kinases. ---> Imatinib is an inhibitor of:
c) smooth muscle cells. ---> The diameter change in resistance arteries resulting
from an increase in sympathetic activity is mainly caused by changes in:
a) macrophages.
b) endothelial cells.
c) smooth muscle cells.
d) fibroblasts.
c) By measuring the vascular resistance during intracoronary infusion of
acetylcholine. ---> An obese man is referred to the cardiologist with signs and
symptoms of myocardial ischemia. Howcould endothelial function be evaluated in
this man?
a) By making an angiogram of the major coronary arteries, filling them with a
contrast fluid.
b) By measuring blood flow during intracoronary infusion of adenosine.
c) By measuring the vascular resistance during intracoronary infusion of
acetylcholine.
d) By determining the pulse wave velocity using the SphygmoCor device.
d) the SphygmoCor system. ---> he manufacturer of the new drug against type 2
diabetes, Sellwithgliftozine, wishes to assess whether the drug lowers augmentation.
This can be investigated by:
