2026/2027 ACCURATE QUESTIONS
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<RECENT VERSION>
1. What is the definition of asthma? - ANSWER ✔ A chronic inflammatory
disorder of the airways.
2. Describe the inflammatory cell infiltration seen immunohistopatholgically in
asthma (5). - ANSWER ✔ -Neutrophils; especially in sudden onset, fatal
asthma exacerbations, occupational asthma and patients who smoke
-Eosinophils
-Lymphocytes
-Mast cell activation
-Epithelium injury
3. What clinical features does airway inflammation contribute to (4)? -
ANSWER ✔ -Hyperresponsiveness
-Airflow limitation
-Respiratory symptoms
-Disease chronicity
4. In some patients persistent changes in airway structure can occur, what are
these changes (5)? - ANSWER ✔ -Sub-basement fibrosis
, -Mucus hypersecretion
-Injury to epithelial cells
-Smooth muscle hypertrophy
-Angiogenesis
5. What is the strongest identifiable predisposing factor for developing asthma?
- ANSWER ✔ Atopy, the genetic predisposition for the development of of
an IgE mediated response to common aeroallergens.
6. A 30-year-old female has a 3-year history of chronic nasal congestion and
rhinitis. She has described this as a frequent "cold" that won't go away and
has noticed progressive anosmia. She has used nasal corticosteroids in the
past for polyps. Over the past few months she has noted intermittent
episodes of chest tightness and shortness of breath.She began taking
ibuprofen 2 days ago for an acute knee strain. Today she presents with an
increasing nonproductive cough and a new onset of dyspnea. On
examination she is afebrile with normal vital signs but appears to be working
to breathe. Auscultation of the lungs reveals diffuse wheezes. A physical
examination is otherwise normal.
Which one of the following is true regarding this situation? - ANSWER ✔
B. Leukotriene modifiers would be particularly effective for managing her
symptoms
7. A 19-year-old male has severe persistent asthma treated with high-dose
inhaled corticosteroids and a long-acting inhaled β-agonist. For the past few
months he has experienced daily wheezing and is using his albuterol
(Proventil, Ventolin) inhaler several times per day. His past medical history
is notable for a history of perennial allergic rhinitis related to a cockroach
allergy.
According to National Asthma Education and Prevention Program
guidelines, which one of the following adjunctive therapies would most
likely be of benefit? - ANSWER ✔ C. Omalizumab (Xolair)
,8. A 7-year-old is brought to the emergency department with a severe asthma
exacerbation that does not respond to a combination of oxygen and
continuous short-acting β-agonists plus ipratropium. Oral corticosteroids
have been given.
Which one of the following medications has been shown to be effective as
adjunctive therapy to improve lung function and decrease hospitalizations? -
ANSWER ✔ E. Intravenous magnesium sulfate
9. While some facets of asthma are reversible, changes seen in chronic,
uncontrolled asthma may be irreversible. Which one of the following
histologic features of irreversible airway remodeling is seen in patients with
chronic asthma? - ANSWER ✔ B. An increased proportion of
myofibroblasts
10.Which one of the following sports is most likely to precipitate bronchospasm
in a patient with exercise-induced asthma? - ANSWER ✔ A. Cross-country
skiing
11.A patient sees you because of almost daily episodes of cough, dyspnea, and
occasional wheezing, which began a few months after she started working in
a bakery. She has a history of mild intermittent asthma that has required
minimal intervention due to infrequent symptoms. You suspect occupational
asthma.
Which one of the following is true about this condition? - ANSWER ✔ E.
Serial measurements of peak expiratory flow rates at work and away from
work are helpful in the diagnostic evaluation
12.You see a 14-year-old female with moderate persistent asthma who has had
two emergency department visits in the last 3 months for asthma
exacerbations. During the discussion with the patient and her father about
how they are monitoring her symptoms and what steps they are taking to
actively manage her disease at home, they indicate that they would benefit
from more information. You develop an asthma action plan with them.
, Which one of the following is true regarding asthma action plans? -
ANSWER ✔ B. Individual studies have shown that the use of asthma action
plans reduces hospitalizations and emergency department visits when used
in the context of asthma self-management programs
13.Asthma: symptoms <2x/ week, nocturnal symptoms <2x month - ANSWER
✔ Mild Intermittent asthma, FEV1 >80%
14.Asthma: symptoms >2x/ week but not daily, nocturnal symptoms >2x
month, - ANSWER ✔ Mild persistent asthma, FEV1 >80%
15.Asthma: daily symptoms, daily SABA use, nocturnal symptoms >2x month -
ANSWER ✔ Moderate persistent asthma, FEV1 60-80%
16.Asthma: Continuous symptoms, limits activity, frequent nocturnal
symptoms - ANSWER ✔ Severe persistent, FEV1 <60%
17.spirometry changes in asthma - ANSWER ✔ FEV1 < 80%, post SABA
FEV1 increase by 12% and 200 mL
18.Inflammatory Mediators of asthma - ANSWER ✔ Interleukins 4 and 5
GM-CSF
Interferon Gamma
TNF alpha
Leukotriene C4
Histamine
19.Irreversible airway changes in asthma - ANSWER ✔ Goblet cell hyperplasia
Microvascular proliferation