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HESI RN Exit Exam (Evolve) – Complete 2025 Study Guide with Verified Answers

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Prepare to ace your HESI RN Exit Exam with this comprehensive, fully updated 2025 study guide based on Evolve questions. This guide includes all major content areas tested on the HESI Exit Exam, including Medical-Surgical, Pediatrics, Maternity, Mental Health, Pharmacology, and Leadership. Inside, you’ll find: Verified correct answers with rationales for each question Step-by-step explanations to reinforce understanding High-yield content summaries for quick review Practice questions mirroring the actual Evolve exam format Tips and strategies for time management and test-taking Sections organized by HESI content areas, making targeted studying easier With this guide, you’ll study smarter, focus on the most important content, and feel fully prepared on exam day. Achieve your A+ HESI score and step confidently toward NCLEX success!

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HESI EXIT EXAM - EVOLVE
QUESTIONS
1. What is an example of a type I hypersensitivity reaction?


A. Anaphylaxis


B. Serum Sickness


C. Contact Dermatitis

D. Blood transfusion reaction

Answer C. Contact Dermatitis




An example of a type I hypersensitivity reaction is anaphylaxis. Serum sickness is a type III immune complex reaction.

Contact dermatitis is a type IV delayed hypersensitivity reaction. A blood transfusion reaction is a type II cytotoxic


reaction.


2. Inhalation Anthrax Clinical Manifestations


A. Fever



,B. Fatigue


C. Rhinitis


D. Dry Cough

E. Sore throat

Answer Fever


Fatigue

Dry Cough


Mild chest pain


3. Which type of immunity will clients acquire through immunizations with live

or killed vaccines?

1


Natural active immunity

2

Artificial active immunity

3



,Natural passive immunity

4

Artificial passive immunity

Answer 2 - Artificial active immunity is acquired through immunization with live or


killed vaccines. Natural active immunity is acquired when there is natural contact with antigens through a clinical


infection. Natural passive immunity is acquired through the transfer of colostrums from mother to child. Artificial passive


immunity is acquired by injecting serum from an immune human.






, 4. Which cytokine increases growth and maturation of myeloid stem cells?1.In-

terleukin-2

2. Thrombopoietin


3. Granulocyte colony-stimulating factor

4. Granulocyte-macrophage colony-stimulating factor

Answer 4. Granulocyte-macrophage colony-stimulating factor is a cytokine that increases growth and


maturation of myeloid stem cells. Interleukin-2 is a cytokine that increases growth and ditterentiation of T-


lymphocytes. Thrombopoietin is a cytokine that increases growth and ditterentiation of platelets. Granulocyte colony-


stimulating factor is a cytokine that increases numbers and maturity of neutrophils.


5. Which autoimmune disease is directly related to the client's central nervous

system?

A. Rheumatic Fever


B. MS


C. Myasthenia Gravis

D. Good pasture syndrome

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