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Psychopharmacology Drugs the Brain And Behavior 3 jj jj jj jj jj jj f f
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to accompany
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Psychopharmacology,ThirdEdition f
Meyer • Quenzer ff ff
Chapter1: Principles of Pharmacology f ff ff f
Multiple Choice ff
1. refer(s) to specific molecular changes that occur when a drug binds to ff ff ff ff ff ff ff ff ff ff ff
a particular target site or receptor, while
ff ff are the resulting widespread
ff ff ff ff ff ff ff ff
alterations in function.
ff jj ff
a. Drug action; therapeutic effects
f ff ff
b. Side effects; drug effects
ff ff ff
c. Therapeutic effects; side effects ff ff ff
d. Drug action; drug effects
ff ff ff
Answer: d ff
Textbook Reference: Pharmacology: The Science of Drug Action
f ff ff ff ff ff ff
2. After drug administration has occurred, the amount of drug in the blood that is
ff ff ff ff ff ff ff ff ff ff ff ff ff
free tobind at specific target sites is referred to as
ff ff ff ff ff ff ff ff ff ff
a. the therapeutic dose.
ff ff
b. first-pass effects. ff
c. bioavailability.
d. ED50.
Answer: c ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
f ff ff ff ff ff
3. The specific molecular changes that occur when a drug binds to a particular
ff ff ff ff ff ff ff ff ff ff ff ff
target site or receptor are referred to as
ff ff jj ff ff ff ff ff
a. drugeffects. f
b. drug action. ff
c. sideeffects. f
d. placebo effects. ff
Answer: b ff
Textbook Reference: Pharmacology: The Science of Drug Action
f ff ff ff ff ff ff
4. Which of the following is not a possible explanation for placebo effects?
ff ff ff ff ff ff ff ff ff ff ff
a. Pavlovian conditioning ff
b. Genetic variation f
c. Drug competition f
d. Expectation of outcome ff ff
Answer: c ff
Textbook Reference: Pharmacology: The Science of Drug Action
f ff ff ff ff ff ff
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5. The administration of oxytocin has been proposed as a treatment for autism. ff ff ff ff ff ff ff ff ff ff
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
f ff ff ff ff ff
6. Which factor does not affect the pharmacokinetics of a drug?
ff ff ff ff ff ff ff ff ff
a. Route of administration ff ff
b. Lipid solubility ff
c. Depot binding ff
d. Drug action ff
Answer: d ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
f ff ff ff ff ff
7. First-pass metabolism occurs when drugs are taken ff ff ff ff ff ff
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
f ff ff ff ff ff
8. The area postrema is one area in the brain where the
ff ff is not complete. ff ff ff ff ff ff ff ff ff ff
a. cerebrospinal fluid ff
b. blood–brain barrier ff
c. choroid plexus ff
d. phospholipid membrane ff
Answer: b ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
f f ff ff ff ff
9. First-pass metabolism occurs with orally administered drugs because
ff ff ff ff ff ff ff
a. their absorption is slowed by food.
ff ff ff ff ff
b. drugs absorbed into the bloodstream from the stomach go to the liver on the
ff ff ff ff ff ff ff ff ff ff ff ff ff
way togeneral circulation.
ff ff ff
c. drugs must first survive the acidic environment of the stomach.
ff ff ff ff ff ff ff ff ff
d. salivary enzymes in the mouth begin the process of metabolism.
f ff ff ff ff ff ff ff ff
Answer: b ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
f ff ff ff ff ff
10. Toxic substances in the blood trigger a vomiting response by activating the
ff ff ff ff ff ff ff ff ff ff ff
a. blood–brain barrier. ff
b. choroid plexus. ff
c. area postrema.
ff
d. median eminence. ff
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Answer: c ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
f ff ff ff ff ff
11. Drugs administered _ have the most rapid onset of action.
ff ff ff ff ff ff ff ff
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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12. Ionization of a drug depends on the of the solution and the
ff ff ff ff ff ff ff ff ff ff of
thedrug.
ff
a. pH; pKa ff
b. pKa; pH ff
c. concentration; lipid solubility ff ff
d. pH; concentration
ff
Answer: a ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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13. The absorption of a drug depends on all of the following except
ff ff ff ff ff ff ff ff ff ff ff
a. lipid solubility.
ff
b. ionization.
c. body temperature. f
d. the concentration of the drug.
ff ff ff ff
Answer: c ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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14. Drugs that are should be avoided by women of childbearing age.
ff ff ff ff ff ff ff ff ff
a. teratogenic
b. able to cross the placental barrier
ff ff ff ff ff
c. psychoactive
d. highlylipid-soluble f
Answer: a ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
f ff ff ff ff ff
15. Agents that induce developmental abnormalities in a fetus are known as
ff ff ff ff ff ff ff ff ff ff
a. psychoactive drugs. ff
b. illicit drugs. ff
c. teratogens.
d. placental drugs. ff
Answer: c ff
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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16. Depot binding is said to occur when drugsff ff ff ff ff ff ff
a. bind to their target sites.
ff ff ff ff
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