VERSION B:
BIOC 405 Winter Quarter 2025 - Exam -
Questions and Verified Answers (
Update) Version B
Content
1. The test consists of 27 questions.
2. Each question has ONE correct answer in bold
3. Each question is worth the same number of points.
1. Which ONE of the following statements is INCORRECT about the hemoglobin binding
curves shown below?
a. Transition from curve (a) to (c) can be achieved by raising the concentration of
protons (as a result of metabolic activity).
b. These hemoglobin binding curves illustrate how delivery of oxygen is modulated
by biochemical conditions.
c. Transition from curve (b) to (d) can be achieved by raising the concentration of
2,3-BPG.
d. The hemoglobin binding curve (c) corresponds to a higher affinity for O2
than curve (b).
1
, 2. You have obtained patient blood samples and would like to distinguish if they have only
received the COVID-19 vaccines or if they have also been recently infected by
SARSCoV-2 (the causative agent of COVID-19). Which ONE of the following methods
will allow you to do so?
a. ELISA to detect anti-SARS-CoV-2 spike antibodies
b. ELISA to detect anti-SARS-CoV-2 nucleoprotein antibodies
c. Size-exclusion chromatography followed by a Bradford assay
d. SDS-PAGE
3. Which ONE of the following statements is INCORRECT regarding influenza virus
infection?
a. Hemagglutinin cleaves sialic acid to allow virus release from the cell and
enables further infections.
b. pH is a key regulator of viral infection.
c. The lower pH within the endosome (relative to the extracellular environment)
facilitates viral infection.
d. Hemagglutinin undergoes large-scale conformational changes to promote viral entry
into a host cell.
4. Which ONE of the following statements is CORRECT about the energy diagram below?
a. The conversion of A to B is exergonic in standard conditions.
b. The conversion of A to B is always spontaneous.
c. If catalyzed by an enzyme, the reaction will be more exergonic than if it is
uncatalyzed.
d. If catalyzed by an enzyme, the reaction will be more endergonic than if it is
uncatalyzed.
5. Which ONE of the following statements is INCORRECT about this Lineweaver-Burk plot
of enzyme inhibition?
2
BIOC 405 Winter Quarter 2025 - Exam -
Questions and Verified Answers (
Update) Version B
Content
1. The test consists of 27 questions.
2. Each question has ONE correct answer in bold
3. Each question is worth the same number of points.
1. Which ONE of the following statements is INCORRECT about the hemoglobin binding
curves shown below?
a. Transition from curve (a) to (c) can be achieved by raising the concentration of
protons (as a result of metabolic activity).
b. These hemoglobin binding curves illustrate how delivery of oxygen is modulated
by biochemical conditions.
c. Transition from curve (b) to (d) can be achieved by raising the concentration of
2,3-BPG.
d. The hemoglobin binding curve (c) corresponds to a higher affinity for O2
than curve (b).
1
, 2. You have obtained patient blood samples and would like to distinguish if they have only
received the COVID-19 vaccines or if they have also been recently infected by
SARSCoV-2 (the causative agent of COVID-19). Which ONE of the following methods
will allow you to do so?
a. ELISA to detect anti-SARS-CoV-2 spike antibodies
b. ELISA to detect anti-SARS-CoV-2 nucleoprotein antibodies
c. Size-exclusion chromatography followed by a Bradford assay
d. SDS-PAGE
3. Which ONE of the following statements is INCORRECT regarding influenza virus
infection?
a. Hemagglutinin cleaves sialic acid to allow virus release from the cell and
enables further infections.
b. pH is a key regulator of viral infection.
c. The lower pH within the endosome (relative to the extracellular environment)
facilitates viral infection.
d. Hemagglutinin undergoes large-scale conformational changes to promote viral entry
into a host cell.
4. Which ONE of the following statements is CORRECT about the energy diagram below?
a. The conversion of A to B is exergonic in standard conditions.
b. The conversion of A to B is always spontaneous.
c. If catalyzed by an enzyme, the reaction will be more exergonic than if it is
uncatalyzed.
d. If catalyzed by an enzyme, the reaction will be more endergonic than if it is
uncatalyzed.
5. Which ONE of the following statements is INCORRECT about this Lineweaver-Burk plot
of enzyme inhibition?
2
