MMSC491 Exam ACTUAL UPDATED
QUESTIONS AND CORRECT ANSWERS
what is the most appropriate gene therapy for treating cancer?
repair of mutant gene
modifying disease cells
killing disease cells
gene augmentation - CORRECT ANSWERS✅✅killing disease cells
which of the following regarding genome-wide gene expression screens is false?
it involves comparative hybridization
they typically microarray
the hybridization probes bind to proteins within the cell
gene specific oligonucleotide probes can be used - CORRECT ANSWERS✅✅the
hybridization probes bind to proteins within the cell
During a tumor removal surgery, the tumor is found to be a small mass of cells that has not
affected any neighboring tissues. Several months later the patient is re-evaluated and is not
showing any signs of recurrence. What kind of tumor did the patient most likely have?
a. malignant tumor
b. liquid tumor
c. benign tumor
d. the mass was misidentified, it was not a tumor - CORRECT ANSWERS✅✅benign tumor
Which, if any, of the following statements is false?
a) The p53 tumor suppressor regulates the G2-M transition in the cell cycle by inhibiting the
CDK2-cyclin E complex.
b) p53 regulates the CDK2-cyclin E complex by stimulating the p21 tumor suppressor.
c) The CDK2-cyclin E complex relies on stimulation by the E2F transcription factor.
d) The RB1 protein normally binds the E2F transcription factor to prevent it working and so
acts as a brake on the cell cycle - CORRECT ANSWERS✅✅a) The p53 tumor suppressor
regulates the G2-M transition in the cell cycle by inhibiting the CDK2-cyclin E complex.
, Which, if any, of the following statements is false?
a) p53 acts as a brake on cell growth but stimulates apoptotic pathways
b) apoptosis occurs only after a death signal is received by one cell from another cell.
c) the death signal starts a pathway that culminates in the activation of a class of proteolytic
enzymes called caspases.
d) caspases attack cellular proteins and release an endonuclease that cleaves the cellular NA
into small fragments - CORRECT ANSWERS✅✅b) apoptosis occurs only after a death
signal is received by one cell from another cell.
Which, if any, of the following statements is false?
a) Chromothripsis is an extraordinary event in which multiple chromosomes within a cell are
shattered into many pieces.
b) Chromothripsis is much more like to occur in cells where the TP53 gene has received loss-
of-function mutations.
c) Kataegis is a type of somatic hypermutation.
d) The mutations involved in a kataegis event are clustered in one subchromosomal region. -
CORRECT ANSWERS✅✅a) Chromothripsis is an extraordinary event in which multiple
chromosomes within a cell are shattered into many pieces.
Which, if any, of the following statements is false?
a) Mismatch repair is dedicated to repairing errors made during DNA replication.
b) MutSα is responsible for recognizing single base mismatches during DNA replication.
c) MutSβ is responsible for recognizing all short insertion and deletion errors made during
DNA replication.
d) MutLα contributes an endonuclease activity that is required to nick the DNA during DNA
repair. - CORRECT ANSWERS✅✅c) MutSβ is responsible for recognizing all short
insertion and deletion errors made during DNA replication.
Concerning prenatal diagnosis, which, if any, of the following statements is true?
a) It relies on surgical procedures to recover fetal tissues from a pregnant woman.
b) Chorion villus biopsies are typically taken around 16 weeks of gestation.
c) Amniotic fluid samples allow culturing of fetal cells for cytogenetic analyses as well as
allowing DNA analyses.
QUESTIONS AND CORRECT ANSWERS
what is the most appropriate gene therapy for treating cancer?
repair of mutant gene
modifying disease cells
killing disease cells
gene augmentation - CORRECT ANSWERS✅✅killing disease cells
which of the following regarding genome-wide gene expression screens is false?
it involves comparative hybridization
they typically microarray
the hybridization probes bind to proteins within the cell
gene specific oligonucleotide probes can be used - CORRECT ANSWERS✅✅the
hybridization probes bind to proteins within the cell
During a tumor removal surgery, the tumor is found to be a small mass of cells that has not
affected any neighboring tissues. Several months later the patient is re-evaluated and is not
showing any signs of recurrence. What kind of tumor did the patient most likely have?
a. malignant tumor
b. liquid tumor
c. benign tumor
d. the mass was misidentified, it was not a tumor - CORRECT ANSWERS✅✅benign tumor
Which, if any, of the following statements is false?
a) The p53 tumor suppressor regulates the G2-M transition in the cell cycle by inhibiting the
CDK2-cyclin E complex.
b) p53 regulates the CDK2-cyclin E complex by stimulating the p21 tumor suppressor.
c) The CDK2-cyclin E complex relies on stimulation by the E2F transcription factor.
d) The RB1 protein normally binds the E2F transcription factor to prevent it working and so
acts as a brake on the cell cycle - CORRECT ANSWERS✅✅a) The p53 tumor suppressor
regulates the G2-M transition in the cell cycle by inhibiting the CDK2-cyclin E complex.
, Which, if any, of the following statements is false?
a) p53 acts as a brake on cell growth but stimulates apoptotic pathways
b) apoptosis occurs only after a death signal is received by one cell from another cell.
c) the death signal starts a pathway that culminates in the activation of a class of proteolytic
enzymes called caspases.
d) caspases attack cellular proteins and release an endonuclease that cleaves the cellular NA
into small fragments - CORRECT ANSWERS✅✅b) apoptosis occurs only after a death
signal is received by one cell from another cell.
Which, if any, of the following statements is false?
a) Chromothripsis is an extraordinary event in which multiple chromosomes within a cell are
shattered into many pieces.
b) Chromothripsis is much more like to occur in cells where the TP53 gene has received loss-
of-function mutations.
c) Kataegis is a type of somatic hypermutation.
d) The mutations involved in a kataegis event are clustered in one subchromosomal region. -
CORRECT ANSWERS✅✅a) Chromothripsis is an extraordinary event in which multiple
chromosomes within a cell are shattered into many pieces.
Which, if any, of the following statements is false?
a) Mismatch repair is dedicated to repairing errors made during DNA replication.
b) MutSα is responsible for recognizing single base mismatches during DNA replication.
c) MutSβ is responsible for recognizing all short insertion and deletion errors made during
DNA replication.
d) MutLα contributes an endonuclease activity that is required to nick the DNA during DNA
repair. - CORRECT ANSWERS✅✅c) MutSβ is responsible for recognizing all short
insertion and deletion errors made during DNA replication.
Concerning prenatal diagnosis, which, if any, of the following statements is true?
a) It relies on surgical procedures to recover fetal tissues from a pregnant woman.
b) Chorion villus biopsies are typically taken around 16 weeks of gestation.
c) Amniotic fluid samples allow culturing of fetal cells for cytogenetic analyses as well as
allowing DNA analyses.
