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Preface
The eleventh edition of Basic & Clinical Pharmacology is a new book in two important ways.
First, the addition of new Associate Editors to the editorial group has increased currency, depth,
and breadth of coverage; second, conversion to fullcolor style has increased the clarity of
presentation and total information content. At the same time, the overall organization has been
improved and the educational content of previous editions has been expanded.
As in prior editions, the book is designed to provide a comprehensive, authoritative, and
readable pharmacology textbook for students in the health sciences. Frequent revision is
necessary to keep pace with the rapid changes in pharmacology and therapeutics; the 2â!“3
year revision cycle of the printed text is among the best in the field and the availability of an
online version provides even greater currency. In addition to the full-color illustrations, other
new features have been introduced. The Case Study at the beginning of chapters and the Drug
Summary Table at the end of chapters will make the learning process even more interesting and
efficient. The book also offers special features that make it a useful reference for house officers
and practicing clinicians.
Information is organized according to the sequence used in many pharmacology courses and in
integrated curricula: basic principles; autonomic drugs; cardiovascular-renal drugs; drugs with
important actions on smooth muscle; central nervous system drugs; drugs used to treat
inflammation, gout, and diseases of the blood; endocrine drugs; chemotherapeutic drugs;
toxicology; and special topics. This sequence builds new information on a foundation of
information already assimilated. For example, early presentation of autonomic nervous system
pharmacology allows students to integrate the physiology and neuroscience they have learned
elsewhere with the pharmacology they are learning and prepares them to understand the
autonomic effects of other drugs. This is especially important for the cardiovascular and central
nervous system drug groups. However, chapters can be used equally well in courses and
curricula that present these topics in a different sequence.
Within each chapter, emphasis is placed on discussion of drug groups and prototypes rather
than offering repetitive detail about individual drugs. Selection of the subject matter and the
order of its presentation are based on the accumulated experience of teaching this material to
thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students.
Major features that make this book particularly useful in integrated curricula include sections
that specifically address the clinical choice and use of drugs in patients and the monitoring of
their effectsâ!”in other words, clinical pharmacology is an integral part of this text. Lists of the
commercial preparations available, including trade and generic names and dosage formulations,
are provided at the end of each chapter for easy reference by the house officer or practitioner
writing a chart order or prescription.
Significant revisions in this edition include:
A Case Study is used to open many chapters, providing an introduction to the clinical
applications of the drugs discussed. Explicit answers are provided at the end of some
chapters but discussion of the concepts involved will be found in the text of all chapters.
A Drug Summary Table is placed at the conclusion of most chapters; these provide a
, concise recapitulation of the most important drugs
Many new illustrations in full color provide significantly more information about drug
mechanisms and effects and help to clarify important concepts
Major revisions of the chapters on sympathomimetic, sympathoplegic, antipsychotic,
antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, nitric
oxide, hypothalamic and pituitary hormones, and immunopharmacology
Continued expansion of the coverage of general concepts relating to newly discovered
receptors, receptor mechanisms, and drug transporters
Descriptions of important new drugs released through December 2008, including
numerous new immunopharmacologic agents
An important related educational resource is Katzung & Trevor's Pharmacology: Examination &
Board Review, eighth edition (Trevor AJ, Katzung BG, & Masters SB: McGraw-Hill, 2008). This
book provides a succinct review of pharmacology with over one thousand sample examination
questions and answers. It is especially helpful to students preparing for board-type
examinations. A more highly condensed source of information suitable for review purposes is
USMLE Road Map: Pharmacology, second edition (Katzung BG, Trevor AJ: McGraw-Hill, 2006).
This edition marks the 27th year of publication of Basic & Clinical Pharmacology. The
widespread adoption of the first ten editions indicates that this book fills an important need. We
believe that the eleventh edition will satisfy this need even more successfully. Spanish,
Portuguese, Italian, French, Indonesian, Japanese, Korean, and Turkish translations are
available. Translations into other languages are under way; the publisher may be contacted for
further information.
I wish to acknowledge the prior and continuing efforts of my contributing authors and the major
contributions of the staff at Lange Medical Publications, Appleton & Lange, and more recently at
McGraw-Hill, and of our editors, Alison Kelley and Donna Frassetto. I also wish to thank my
wife, Alice Camp, for her expert proofreading contributions since the first edition.
Special thanks and recognition are due James Ransom, PhD, the long-time Senior Editor at
Lange Medical Publications, who provided major inspiration and invaluable guidance through the
first eight editions of the book. Without him, this book would not exist.
Suggestions and comments about Basic & Clinical Pharmacology are always welcome. They may
be sent to me at the Department of Cellular & Molecular Pharmacology, P.O. Box 0450,
University of California, San Francisco, CA 94143-0450.
Bertram G. Katzung, MD, PhD
San Francisco
February, 2009
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Copyright Information
Basic & Clinical Pharmacology, Eleventh Edition
Copyright © 2009 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in China.
Except as permitted under the United States Copyright Act of 1976, no part of this publication
may be reproduced or distributed in any form or by any means, or stored in a data base or
retrieval system, without the prior written permission of the publisher.
Previous editions copyright © 2007, 2004, 2001 by McGraw-Hill Companies, Inc.; copyright ©
1998, 1995, 1992, 1989, 1987 by Appleton & Lange; copyright © 1984, 1982 by Lange Medical
Publications
ISBN 978-0-07-160405-5
Notice
Medicine is an ever-changing science. As new research and clinical experience broaden our
knowledge, changes in treatment and drug therapy are required. The authors and the publisher
of this work have checked with sources believed to be reliable in their efforts to provide
information that is complete and generally in accord with the standards accepted at the time of
publication. However, in view of the possibility of human error or changes in medical sciences,
neither the authors nor the publisher nor any other party who has been involved in the
preparation or publication of this work warrants that the information contained herein is in every
respect accurate or complete, and they disclaim all responsibility for any errors or omissions or
for the results obtained from use of the information contained in this work. Readers are
encouraged to confirm the information contained herein with other sources. For example and in
particular, readers are advised to check the product information sheet included in the package of
each drug they plan to administer to be certain that the information contained in this work is
accurate and that changes have not been made in the recommended dose or in the
contraindications for administration. This recommendation is of particular importance in
connection with new or infrequently used drugs.
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Contributors
Editors
Bertram G. Katzung, MD, PhD
Professor Emeritus
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
Associate Editors
Susan B. Masters, PhD
Professor of Pharmacology & Academy Chair of Pharmacology Education
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
Anthony J. Trevor, PhD
Professor Emeritus
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
Authors
Emmanuel T. Akporiaye, PhD
Professor, Department of Microbiology and Immunology, University of Arizona Health Sciences
Center, Tucson
Michael J. Aminoff, MD, DSc, FRCP
Professor, Department of Neurology, University of California, San Francisco
Allan I. Basbaum, PhD
Professor and Chair, Department of Anatomy and W.M. Keck Foundation Center for Integrative
Neuroscience, University of California, San Francisco
Neal L. Benowitz, MD
Professor of Medicine, Psychiatry, and Biopharmaceutical Sciences, University of California, San
Francisco
Barry A. Berkowitz, PhD
Adjunct Professor, Northeastern University, Boston University; CEO and President, Cetek
Corporation, Marlborough, Massachusetts
Italo Biaggioni, MD
Preface
The eleventh edition of Basic & Clinical Pharmacology is a new book in two important ways.
First, the addition of new Associate Editors to the editorial group has increased currency, depth,
and breadth of coverage; second, conversion to fullcolor style has increased the clarity of
presentation and total information content. At the same time, the overall organization has been
improved and the educational content of previous editions has been expanded.
As in prior editions, the book is designed to provide a comprehensive, authoritative, and
readable pharmacology textbook for students in the health sciences. Frequent revision is
necessary to keep pace with the rapid changes in pharmacology and therapeutics; the 2â!“3
year revision cycle of the printed text is among the best in the field and the availability of an
online version provides even greater currency. In addition to the full-color illustrations, other
new features have been introduced. The Case Study at the beginning of chapters and the Drug
Summary Table at the end of chapters will make the learning process even more interesting and
efficient. The book also offers special features that make it a useful reference for house officers
and practicing clinicians.
Information is organized according to the sequence used in many pharmacology courses and in
integrated curricula: basic principles; autonomic drugs; cardiovascular-renal drugs; drugs with
important actions on smooth muscle; central nervous system drugs; drugs used to treat
inflammation, gout, and diseases of the blood; endocrine drugs; chemotherapeutic drugs;
toxicology; and special topics. This sequence builds new information on a foundation of
information already assimilated. For example, early presentation of autonomic nervous system
pharmacology allows students to integrate the physiology and neuroscience they have learned
elsewhere with the pharmacology they are learning and prepares them to understand the
autonomic effects of other drugs. This is especially important for the cardiovascular and central
nervous system drug groups. However, chapters can be used equally well in courses and
curricula that present these topics in a different sequence.
Within each chapter, emphasis is placed on discussion of drug groups and prototypes rather
than offering repetitive detail about individual drugs. Selection of the subject matter and the
order of its presentation are based on the accumulated experience of teaching this material to
thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students.
Major features that make this book particularly useful in integrated curricula include sections
that specifically address the clinical choice and use of drugs in patients and the monitoring of
their effectsâ!”in other words, clinical pharmacology is an integral part of this text. Lists of the
commercial preparations available, including trade and generic names and dosage formulations,
are provided at the end of each chapter for easy reference by the house officer or practitioner
writing a chart order or prescription.
Significant revisions in this edition include:
A Case Study is used to open many chapters, providing an introduction to the clinical
applications of the drugs discussed. Explicit answers are provided at the end of some
chapters but discussion of the concepts involved will be found in the text of all chapters.
A Drug Summary Table is placed at the conclusion of most chapters; these provide a
, concise recapitulation of the most important drugs
Many new illustrations in full color provide significantly more information about drug
mechanisms and effects and help to clarify important concepts
Major revisions of the chapters on sympathomimetic, sympathoplegic, antipsychotic,
antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, nitric
oxide, hypothalamic and pituitary hormones, and immunopharmacology
Continued expansion of the coverage of general concepts relating to newly discovered
receptors, receptor mechanisms, and drug transporters
Descriptions of important new drugs released through December 2008, including
numerous new immunopharmacologic agents
An important related educational resource is Katzung & Trevor's Pharmacology: Examination &
Board Review, eighth edition (Trevor AJ, Katzung BG, & Masters SB: McGraw-Hill, 2008). This
book provides a succinct review of pharmacology with over one thousand sample examination
questions and answers. It is especially helpful to students preparing for board-type
examinations. A more highly condensed source of information suitable for review purposes is
USMLE Road Map: Pharmacology, second edition (Katzung BG, Trevor AJ: McGraw-Hill, 2006).
This edition marks the 27th year of publication of Basic & Clinical Pharmacology. The
widespread adoption of the first ten editions indicates that this book fills an important need. We
believe that the eleventh edition will satisfy this need even more successfully. Spanish,
Portuguese, Italian, French, Indonesian, Japanese, Korean, and Turkish translations are
available. Translations into other languages are under way; the publisher may be contacted for
further information.
I wish to acknowledge the prior and continuing efforts of my contributing authors and the major
contributions of the staff at Lange Medical Publications, Appleton & Lange, and more recently at
McGraw-Hill, and of our editors, Alison Kelley and Donna Frassetto. I also wish to thank my
wife, Alice Camp, for her expert proofreading contributions since the first edition.
Special thanks and recognition are due James Ransom, PhD, the long-time Senior Editor at
Lange Medical Publications, who provided major inspiration and invaluable guidance through the
first eight editions of the book. Without him, this book would not exist.
Suggestions and comments about Basic & Clinical Pharmacology are always welcome. They may
be sent to me at the Department of Cellular & Molecular Pharmacology, P.O. Box 0450,
University of California, San Francisco, CA 94143-0450.
Bertram G. Katzung, MD, PhD
San Francisco
February, 2009
, Close Window
Copyright Information
Basic & Clinical Pharmacology, Eleventh Edition
Copyright © 2009 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in China.
Except as permitted under the United States Copyright Act of 1976, no part of this publication
may be reproduced or distributed in any form or by any means, or stored in a data base or
retrieval system, without the prior written permission of the publisher.
Previous editions copyright © 2007, 2004, 2001 by McGraw-Hill Companies, Inc.; copyright ©
1998, 1995, 1992, 1989, 1987 by Appleton & Lange; copyright © 1984, 1982 by Lange Medical
Publications
ISBN 978-0-07-160405-5
Notice
Medicine is an ever-changing science. As new research and clinical experience broaden our
knowledge, changes in treatment and drug therapy are required. The authors and the publisher
of this work have checked with sources believed to be reliable in their efforts to provide
information that is complete and generally in accord with the standards accepted at the time of
publication. However, in view of the possibility of human error or changes in medical sciences,
neither the authors nor the publisher nor any other party who has been involved in the
preparation or publication of this work warrants that the information contained herein is in every
respect accurate or complete, and they disclaim all responsibility for any errors or omissions or
for the results obtained from use of the information contained in this work. Readers are
encouraged to confirm the information contained herein with other sources. For example and in
particular, readers are advised to check the product information sheet included in the package of
each drug they plan to administer to be certain that the information contained in this work is
accurate and that changes have not been made in the recommended dose or in the
contraindications for administration. This recommendation is of particular importance in
connection with new or infrequently used drugs.
, Close Window
Contributors
Editors
Bertram G. Katzung, MD, PhD
Professor Emeritus
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
Associate Editors
Susan B. Masters, PhD
Professor of Pharmacology & Academy Chair of Pharmacology Education
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
Anthony J. Trevor, PhD
Professor Emeritus
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
Authors
Emmanuel T. Akporiaye, PhD
Professor, Department of Microbiology and Immunology, University of Arizona Health Sciences
Center, Tucson
Michael J. Aminoff, MD, DSc, FRCP
Professor, Department of Neurology, University of California, San Francisco
Allan I. Basbaum, PhD
Professor and Chair, Department of Anatomy and W.M. Keck Foundation Center for Integrative
Neuroscience, University of California, San Francisco
Neal L. Benowitz, MD
Professor of Medicine, Psychiatry, and Biopharmaceutical Sciences, University of California, San
Francisco
Barry A. Berkowitz, PhD
Adjunct Professor, Northeastern University, Boston University; CEO and President, Cetek
Corporation, Marlborough, Massachusetts
Italo Biaggioni, MD
