Update ) Advanced
Pharmacology for Care of the Family
| Questions with Answers | Grade A
| 100% Correct – Chamberlain
Question:
If pramipexole is combined with levodopa what are common side effects?
Answer:
Orthostatic hypotension and dyskinesias, increased incidence of
hallucinations.
Question:
When is pramipexole best used in treating Parkinson's?
Answer:
Pramipexole and ropinirole are best used as first line drugs or as
supplementation to levodopa. More severe symptoms may need levodopa.
,Question:
When should COMT inhibitors (entacapone and tolcapone) be used?
Answer:
When patients experience wearing off of the effects of levodopa. Can also be
used to allow decrease in levodopa dosage.
Question:
What are sleep attacks related to PD treatment?
Answer:
Overwhelming sleepiness when taking pramipexole that occurs without
warning and is not like general sleepiness when taking dopaminergic agents.
Question:
What is the most common side effect of Bromocriptine?
Answer:
Nausea, psychological reactions. Most adverse effects are due to high dosage,
dose must be tapered.
,Question:
How is levodopa/carbidopa utilized in PD?
Answer:
First-line drug or supplement to a dopamine agonist. For patients with most
severe symptoms treatment should begin with this drug.
Question:
If improvement of motor function is primary objective in PD treatment, what
drug is preferred?
Answer:
Levodopa
Question:
What are the common side effects of Phenytoin?
Answer:
Ataxia, peripheral neuropathy, gum hyperplasia, hepatotoxicity
Question:
How can gingival hyperplasia from Phenytoin be prevented?
Answer:
Promote good oral hygiene.
, Question:
Why should Phenytoin be avoided in pregnancy?
Answer:
It is a teratogen, can cause cleft palate, heart malformations and fetal
hydantoin syndrome characterized by growth deficiency, motor or mental
deficits, microcephaly, craniofacial distortion, and impaired developments.
Question:
Phenytoin can decrease the effects of what drugs?
Answer:
Oral contraceptives, warfarin, and glucocorticoids.
Question:
What drugs can decrease phenytoin levels?
Answer:
Carbamazepine, phenobarbital, and chronic alcohol use. Can result in
breakthrough seizures.