TESTBANK
v
, Chapter1:PrinciplesofPharmacology v v v v
Multiple Choice v
1. refer(s) to specific molecular changes that occur when a drug binds to a
v v v v v v v v v v v v
particular target site or receptor, while
v v aretheresulting widespread alterations
v v v v v v v v
in function.
v v
a. Drug action; therapeutic effects
v v v
b. Side effects; drug effects
v v v
c. Therapeutic effects; side effects v v v
d. Drug action; drug effects
v v v
Answer: d v
Textbook Reference: Pharmacology: The Science of Drug Action
v v v v v v v
2. After drug administration has occurred, the amount of drug in the blood that is free to bind
v v v v v v v v v v v v v v v v
at specific target sites is referred to as
v v v v v v v v
a. the therapeutic dose.
v v
b. first-pass effects. v
c. bioavailability.
d. ED50.
Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
3. The specific molecular changes that occur when a drug binds to a particular target site or
v v v v v v v v v v v v v v v
receptor are referred to as
v v v v v
a. drugeffects. v
b. drug action. v
c. side effects.
v
d. placebo effects. v
Answer: b v
TextbookReference: Pharmacology: TheScience of Drug Action
v v v v v v v
4. Which of the following is not a possible explanation for placebo effects?
v v v v v v v v v v v
a. Pavlovian conditioning v
b. Genetic variation v
c. Drug competition v
d. Expectation of outcome v v
Answer: c v
TextbookReference: Pharmacology: The Science of Drug Action
v v v v v v v
Page 1 of 247
v v v
,5. The administration of oxytocin has been proposed as a treatment for autism. v v v v v v v v v v
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
6. Which factor does not affect the pharmacokinetics of a drug?
v v v v v v v v v
a. Route of administration
v v
b. Lipid solubility
v
c. Depot binding v
d. Drugaction v
Answer: d v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
7. First-pass metabolism occurs when drugs are taken
v v v v v v
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
8. The area postrema is one area in the brain where the
v v is not complete. v v v v v v v v v v
a. cerebrospinal fluid v
b. blood–brain barrier v
c. choroid plexus v
d. phospholipid membrane v
Answer: b v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
9. First-pass metabolism occurs with orally administered drugs because
v v v v v v v
a. their absorption is slowed by food.
v v v v v
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
v v v v v v v v v v v v v v v
general circulation.
v v
c. drugs must first survive the acidic environment of the stomach.
v v v v v v v v v
d. salivaryenzymes in the mouth begin the process of metabolism.
v v v v v v v v v
Answer: b v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
10. Toxic substances in the blood trigger a vomiting response by activating the
v v v v v v v v v v v
a. blood–brain barrier. v
b. choroid plexus. v
c. area postrema.
v
d. median eminence. v
Page 2 of 247
v v v
, Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
11. Drugs administered _ have the most rapid onset of action.
v v v v v v v v
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
12. Ionization of a drug depends on the of the solution and the
v v v v v v v v v v ofthe
v
drug.
v
a. pH; pKa
v
b. pKa; pH v
c. concentration; lipid solubility v v
d. pH; concentration
v
Answer: a v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
13. The absorption of a drug depends on all of the following except
v v v v v v v v v v v
a. lipid solubility.
v
b. ionization.
c. body temperature. v
d. the concentration of the drug.
v v v v
Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
14. Drugs that are should be avoided by women of childbearing age.
v v v v v v v v v
a. teratogenic
b. able to cross the placental barrier
v v v v v
c. psychoactive
d. highly lipid-soluble v
Answer: a v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
15. Agents that induce developmental abnormalities in a fetus are known as
v v v v v v v v v v
a. psychoactivedrugs. v
b. illicit drugs. v
c. teratogens.
d. placental drugs. v
Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
16. Depot binding is said to occur when drugsv v v v v v v
a. bind to their target sites.
v v v v
Page 3 of 247
v v v
v
, Chapter1:PrinciplesofPharmacology v v v v
Multiple Choice v
1. refer(s) to specific molecular changes that occur when a drug binds to a
v v v v v v v v v v v v
particular target site or receptor, while
v v aretheresulting widespread alterations
v v v v v v v v
in function.
v v
a. Drug action; therapeutic effects
v v v
b. Side effects; drug effects
v v v
c. Therapeutic effects; side effects v v v
d. Drug action; drug effects
v v v
Answer: d v
Textbook Reference: Pharmacology: The Science of Drug Action
v v v v v v v
2. After drug administration has occurred, the amount of drug in the blood that is free to bind
v v v v v v v v v v v v v v v v
at specific target sites is referred to as
v v v v v v v v
a. the therapeutic dose.
v v
b. first-pass effects. v
c. bioavailability.
d. ED50.
Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
3. The specific molecular changes that occur when a drug binds to a particular target site or
v v v v v v v v v v v v v v v
receptor are referred to as
v v v v v
a. drugeffects. v
b. drug action. v
c. side effects.
v
d. placebo effects. v
Answer: b v
TextbookReference: Pharmacology: TheScience of Drug Action
v v v v v v v
4. Which of the following is not a possible explanation for placebo effects?
v v v v v v v v v v v
a. Pavlovian conditioning v
b. Genetic variation v
c. Drug competition v
d. Expectation of outcome v v
Answer: c v
TextbookReference: Pharmacology: The Science of Drug Action
v v v v v v v
Page 1 of 247
v v v
,5. The administration of oxytocin has been proposed as a treatment for autism. v v v v v v v v v v
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
6. Which factor does not affect the pharmacokinetics of a drug?
v v v v v v v v v
a. Route of administration
v v
b. Lipid solubility
v
c. Depot binding v
d. Drugaction v
Answer: d v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
7. First-pass metabolism occurs when drugs are taken
v v v v v v
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
8. The area postrema is one area in the brain where the
v v is not complete. v v v v v v v v v v
a. cerebrospinal fluid v
b. blood–brain barrier v
c. choroid plexus v
d. phospholipid membrane v
Answer: b v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
9. First-pass metabolism occurs with orally administered drugs because
v v v v v v v
a. their absorption is slowed by food.
v v v v v
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
v v v v v v v v v v v v v v v
general circulation.
v v
c. drugs must first survive the acidic environment of the stomach.
v v v v v v v v v
d. salivaryenzymes in the mouth begin the process of metabolism.
v v v v v v v v v
Answer: b v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
10. Toxic substances in the blood trigger a vomiting response by activating the
v v v v v v v v v v v
a. blood–brain barrier. v
b. choroid plexus. v
c. area postrema.
v
d. median eminence. v
Page 2 of 247
v v v
, Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
11. Drugs administered _ have the most rapid onset of action.
v v v v v v v v
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
12. Ionization of a drug depends on the of the solution and the
v v v v v v v v v v ofthe
v
drug.
v
a. pH; pKa
v
b. pKa; pH v
c. concentration; lipid solubility v v
d. pH; concentration
v
Answer: a v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
13. The absorption of a drug depends on all of the following except
v v v v v v v v v v v
a. lipid solubility.
v
b. ionization.
c. body temperature. v
d. the concentration of the drug.
v v v v
Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
14. Drugs that are should be avoided by women of childbearing age.
v v v v v v v v v
a. teratogenic
b. able to cross the placental barrier
v v v v v
c. psychoactive
d. highly lipid-soluble v
Answer: a v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
15. Agents that induce developmental abnormalities in a fetus are known as
v v v v v v v v v v
a. psychoactivedrugs. v
b. illicit drugs. v
c. teratogens.
d. placental drugs. v
Answer: c v
TextbookReference: Pharmacokinetic Factors Determining Drug Action
v v v v v v
16. Depot binding is said to occur when drugsv v v v v v v
a. bind to their target sites.
v v v v
Page 3 of 247
v v v
