ANCC FNP 2025: COMPLETE 500-QUESTION REAL
EXAM WITH VERIFIED ANSWERS, CLINICAL
RATIONALES, AND HIGH-YIELD REVIEW FOR
LIFESPAN PRIMARY CARE
Overview:
This comprehensive practice exam is designed for Family Nurse Practitioner (FNP) candidates preparing for the
American Nurses Credentialing Center (ANCC) FNP Certification Exam 2025. It contains 500 multiple-choice
questions with correct, verified answers and concise rationales to help you understand key concepts and clinical
decision-making.
The exam covers:
Primary care across the lifespan – pediatrics, adult, and geriatric care
Health promotion and disease prevention – screening, counseling, and immunizations
Common acute and chronic conditions – cardiovascular, respiratory, endocrine, gastrointestinal,
musculoskeletal, neurological, dermatological, and infectious diseases
Diagnostic reasoning and clinical decision-making – labs, imaging, and symptom evaluation
Pharmacology and therapeutic management – medications, indications, contraindications, and side
effects
Emergency and urgent care scenarios – recognizing and managing acute conditions
Women's and reproductive health – contraception, pregnancy, and menopause
Behavioral and mental health – counseling, motivational interviewing, and psychiatric considerations
Features:
500 high-yield, clinically relevant questions
Correct answers with brief rationales for immediate learning
Questions structured to mirror the ANCC exam style
Coverage of latest 2025 guidelines and evidence-based practice
Purpose:
This exam is intended to assess readiness for the ANCC FNP certification and reinforce clinical knowledge,
critical thinking, and test-taking strategies. Whether used as a self-assessment, study guide, or final review tool,
it provides a robust preparation resource for achieving a passing score.
,Question 1
Which health promotion strategy is most effective for adolescents who are
obese?
1. Individual-based behavior modification
2. Motivational interviewing ✅
3. Parents controlling all meals
4. Showing video case studies
Answer: 2. Motivational interviewing
Rationale: Motivational interviewing helps adolescents identify their own goals
and strategies for lifestyle change. It is more effective than direct instructions or
passive educational methods.
Question 2
A nursing mother develops postpartum mastitis. What is the best advice?
1. Temporarily switch to formula
2. Pump only the unaffected breast
3. Continue to nurse with both breasts ✅
4. Take cool showers
Answer: 3. Continue nursing with both breasts
Rationale: Continuing breastfeeding helps drain the infected breast, reduces milk
stasis, and promotes healing. Antibiotics should be taken as prescribed.
Question 3
,A patient post-total gastrectomy complains of sore mouth, indigestion, and
tingling in the lower extremities. What test should be ordered?
1. Blood urea nitrogen
2. Complete blood count ✅
3. Liver function tests
4. Thyroid function tests
Answer: 2. Complete blood count
Rationale: These symptoms suggest vitamin B12 deficiency and megaloblastic
anemia, which is best identified with a CBC.
Question 4
A 42-year-old presents with epistaxis, dilated pupils, tachycardia, and mild
euphoria. The likely cause is:
1. Benzodiazepine (Alprazolam)
2. Cocaine ✅
3. Morphine (MS Contin)
4. Oxycodone (OxyContin)
Answer: 2. Cocaine
Rationale: Cocaine is a stimulant causing tachycardia, mydriasis, euphoria, and
nasal irritation/bleeding.
Question 5
A patient has a chronic, scaly, well-circumscribed plaque on the gluteal fold.
Diagnosis?
1. Atopic dermatitis
2. Ichthyosis
3. Psoriasis ✅
4. Tinea corporis
, Answer: 3. Psoriasis
Rationale: Chronic, nonpruritic, well-demarcated erythematous plaques with
scales are classic for psoriasis.
Question 6
During cardiac auscultation, a soft first heart sound with a holosystolic apical
murmur radiating to the axilla suggests:
1. Aortic stenosis
2. Mitral regurgitation ✅
3. Mitral stenosis
4. Mitral valve prolapse
Answer: 2. Mitral regurgitation
Rationale: A holosystolic murmur at the apex radiating to the axilla is
characteristic of mitral regurgitation.
Question 7
Which viral infection is associated with atypical lymphocytes during acute
infection?
1. Cytomegalovirus (CMV)
2. Epstein-Barr virus (EBV) ✅
3. Human papillomavirus (HPV)
4. Coxsackievirus
Answer: 2. Epstein-Barr virus
Rationale: EBV (mononucleosis) often produces atypical lymphocytes in
peripheral blood.
EXAM WITH VERIFIED ANSWERS, CLINICAL
RATIONALES, AND HIGH-YIELD REVIEW FOR
LIFESPAN PRIMARY CARE
Overview:
This comprehensive practice exam is designed for Family Nurse Practitioner (FNP) candidates preparing for the
American Nurses Credentialing Center (ANCC) FNP Certification Exam 2025. It contains 500 multiple-choice
questions with correct, verified answers and concise rationales to help you understand key concepts and clinical
decision-making.
The exam covers:
Primary care across the lifespan – pediatrics, adult, and geriatric care
Health promotion and disease prevention – screening, counseling, and immunizations
Common acute and chronic conditions – cardiovascular, respiratory, endocrine, gastrointestinal,
musculoskeletal, neurological, dermatological, and infectious diseases
Diagnostic reasoning and clinical decision-making – labs, imaging, and symptom evaluation
Pharmacology and therapeutic management – medications, indications, contraindications, and side
effects
Emergency and urgent care scenarios – recognizing and managing acute conditions
Women's and reproductive health – contraception, pregnancy, and menopause
Behavioral and mental health – counseling, motivational interviewing, and psychiatric considerations
Features:
500 high-yield, clinically relevant questions
Correct answers with brief rationales for immediate learning
Questions structured to mirror the ANCC exam style
Coverage of latest 2025 guidelines and evidence-based practice
Purpose:
This exam is intended to assess readiness for the ANCC FNP certification and reinforce clinical knowledge,
critical thinking, and test-taking strategies. Whether used as a self-assessment, study guide, or final review tool,
it provides a robust preparation resource for achieving a passing score.
,Question 1
Which health promotion strategy is most effective for adolescents who are
obese?
1. Individual-based behavior modification
2. Motivational interviewing ✅
3. Parents controlling all meals
4. Showing video case studies
Answer: 2. Motivational interviewing
Rationale: Motivational interviewing helps adolescents identify their own goals
and strategies for lifestyle change. It is more effective than direct instructions or
passive educational methods.
Question 2
A nursing mother develops postpartum mastitis. What is the best advice?
1. Temporarily switch to formula
2. Pump only the unaffected breast
3. Continue to nurse with both breasts ✅
4. Take cool showers
Answer: 3. Continue nursing with both breasts
Rationale: Continuing breastfeeding helps drain the infected breast, reduces milk
stasis, and promotes healing. Antibiotics should be taken as prescribed.
Question 3
,A patient post-total gastrectomy complains of sore mouth, indigestion, and
tingling in the lower extremities. What test should be ordered?
1. Blood urea nitrogen
2. Complete blood count ✅
3. Liver function tests
4. Thyroid function tests
Answer: 2. Complete blood count
Rationale: These symptoms suggest vitamin B12 deficiency and megaloblastic
anemia, which is best identified with a CBC.
Question 4
A 42-year-old presents with epistaxis, dilated pupils, tachycardia, and mild
euphoria. The likely cause is:
1. Benzodiazepine (Alprazolam)
2. Cocaine ✅
3. Morphine (MS Contin)
4. Oxycodone (OxyContin)
Answer: 2. Cocaine
Rationale: Cocaine is a stimulant causing tachycardia, mydriasis, euphoria, and
nasal irritation/bleeding.
Question 5
A patient has a chronic, scaly, well-circumscribed plaque on the gluteal fold.
Diagnosis?
1. Atopic dermatitis
2. Ichthyosis
3. Psoriasis ✅
4. Tinea corporis
, Answer: 3. Psoriasis
Rationale: Chronic, nonpruritic, well-demarcated erythematous plaques with
scales are classic for psoriasis.
Question 6
During cardiac auscultation, a soft first heart sound with a holosystolic apical
murmur radiating to the axilla suggests:
1. Aortic stenosis
2. Mitral regurgitation ✅
3. Mitral stenosis
4. Mitral valve prolapse
Answer: 2. Mitral regurgitation
Rationale: A holosystolic murmur at the apex radiating to the axilla is
characteristic of mitral regurgitation.
Question 7
Which viral infection is associated with atypical lymphocytes during acute
infection?
1. Cytomegalovirus (CMV)
2. Epstein-Barr virus (EBV) ✅
3. Human papillomavirus (HPV)
4. Coxsackievirus
Answer: 2. Epstein-Barr virus
Rationale: EBV (mononucleosis) often produces atypical lymphocytes in
peripheral blood.
