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USMLE STEP 2 QUESTIONS AND OUTLINED ANSWERS || CLINICAL KNOWLEDGE || SKILLS || CLINICAL SCIENCE || ALL TESTED QUESTIONS

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USMLE STEP 2 QUESTIONS AND OUTLINED ANSWERS || CLINICAL KNOWLEDGE || SKILLS || CLINICAL SCIENCE || ALL TESTED QUESTIONS .Obese Child with dull hip PAIN or referred knee pain and a painful limp with restricted ROM and inability to bear weight on exam has limited rotation and abduction of the hip Diagnosis & Tx? - Answer-Slipped Capital Femoral Epiphysis requires immediate surgical screw fixation to reduce risk of AVN .chronic, progressive leg pain and limp in a 3-12 yo Boy Limited abduction and internal rotation. Atrophy of proximal thigh muscles. Diagnosis & Tx? - Answer-Legg-Calve-Perthes Disease or Idiopathic Osteonecrosis (avascular necrosis) of the femoral epiphysis. -Flattened and fragmented femoral head on radiograph Tx: Mild: Observation Moderate: bracing, hip abduction with a petrie cast Extensive: osteotomy .fall in systemic arterial pressure by more than 10mmHg during inspiration. What is it? and what cardiac problem is it associated with? - Answer-pulsus paradoxus -Associated with cardiac Tamponade -Becktriad can diagnose acute cardiac tamponade: 1. JVD (Kussmaul sign (increased JVD on inspiration)) 2. Hypotension 3. Distant heart sounds fluid accumulation in pericardial cavity increases intrapericardial pressure restricting venous return to the heart lowering R & L ventricular filling. Net result = Decreased Preload, Stroke Volume , Cardiac output. .Pulsus Parvus (decreased pulse amplitude) and Pulsus Tardus (delayed pulse upstroke) (weak,delayed carotid upstroke) and a single or paradoxically split S2 sound; systolic murmur radiating to the carotids. associated with what cardiac defect? - Answer-aortic stenosis Most common causes: 1. senile calcific aortic stenosis (Elderly) 2. bicuspid aortic valve (70 yo) 3. rheumatic heart disease high resistance generated by stenosed aortic valve causes concentric hypertrophy and stiffening of the left ventricle (S4) leading to CHF. .Bounding or "water hammer" pulses, with widened pulse pressure and head bob with heartbeat are associated with what cardiac defect? Common etiologies? Treatment? - Answer-aortic regurgitation -Congenital Bicuspid Aortic Valve, Rheumatic Heart Disease, Endocarditits, Aortic Root Dilation (Marfan, Syphilis) -tx: Vasodilator therapy (dihydropyridines or ACEIs) for isolated aortic regurgitation until symptoms become severe enough to warrant valve replacement. .Acute popping sensation in knee with catching, and locking, and slow onset joint effusion. patient complains of sensation of instability. with joint line tenderness on exam. What is the problem, Diagnosis, and management? - Answer-meniscal tear -MRI for diagnosis -Mild, older patient: REST, NSAID -Impaired activity, young: SURGERY .postprandial pain, vomiting with early satiety. Abdominal succussion splash. Patient ingested acid 3 months ago. diagnosis? common causes? - Answer-Pyloric stricture -Upper Endoscopy required to confirm diagnosis and treatment is surgical. -Common causes of GASTRIC OUTLET OBSTRUCTION: Gastric malignancy, PUD, Crohns, Strictures from caustic ingestion, gastric bezoars. .Chronic nausea, vomiting and early satiety in a chronic diabetic. What is the diagnosis? How is it treated? - Answer-diabetic gastroparesis -Treat with pro-motility agent such as metoclopramide, exercise, and low fat diet -Gastric Emptying study would be helpful in evaluating .Adolescent with progressive gait instability, dysarthria, wide based gait, marked atrophy of medulla and dorsal columns of the spinal cord (loss of vibration and position sense), and scoliosis. What is the diagnosis? Risk of mortality? - Answer-Friedreich's ataxia -AR (loss of function trinucleotide repeat (GAA) in Frataxin gene -Mortality due to cardiac dysfunction (hypertrophic cardiomyopathy) Genetic testing required to confirm diagnosis. Management is supportive as no disease modifying therapies are available. .Child with conjunctival injection, watery discharge, tarsal inflammation, and pale follicles. As well as rhinorrhea, Pharyngitis. Diagnosis? Cause? Treatment? - Answer-TRACHOMA ( due to Chlamydia trachomatis) -Treat with Oral Azithromycin .Conjunctival injection, eye discharge and swollen eyelids 2-5 days after birth? - Answer-Gonococcal conjunctivitis .Conjunctival injection, eye discharge and swollen eyelids 5-14 days after birth? - Answer-Chlamydial conjunctivitis .Abrupt onset of fever, proptosis, restriction of extra ocular movements, swollen, red eyelids. Unilateral. Paranasal sinus infection. Diagnosis? - Answer-Orbital cellulitis (Infection posterior to orbital septum) Most common risk factor = SINUSITIS (ethmoid or maxillary) NEED CT SCAN OF ORBITS AND SINUSES IV ABX mainstay of tx and drainage .Patient with hx of Schizoaffective disorder on treatment. Presenting with Orofacial dyskinesia (rhythmic movements of face, smacking lips, sticking out tongue) and choreoathetoid movement of trunk and extremities. Underlying cause? How to treat it? - Answer-Tardive Dyskinesia Dopamine receptor upregulation and supersensitivity, from chronic blockade of dopamine receptors. From first generation antipsychotics (potent D2 blockers). Tx: Discontinue med, Switch to second gen antipsychotic (Clozapine), treat with Valbenazine (Vesicular Monoamine Transporter 2 Inhibitor) .Choreiform movements (facial grimacing, ataxia, dystonia, tongue protrusion, writhing movements), Psychiatric symptoms, dementia. Caudate nucleus atrophy on MRI. Diagnosis? - Answer-Huntington's disease ATROPHY of the CAUDATE AD 30-50yo .Cyclic lower abdominal pain, Bulk symptoms (defecatory and urinary dysfunction), primary amenorrhea, suprapubic mass, blue tinged vaginal mass (Hematocolpos). Diagnosis and treatment? - Answer-imperforate hymen -Hymenal incision and drainage .No vaginal bleeding, Closed Cervical Os, No fetal cardiac activity or empty sac. Type of Miscarriage? - Answer-missed abortion .Vaginal Bleeding, Closed cervical os, Fetal cardiac activity. Type of miscarriage? - Answer-threatened abortion .Vaginal bleeding, dilated cervical os, products of conception seen or felt at or above cervical os. Type of miscarriage? - Answer-Inevitable abortion .vaginal bleeding, dilated cervical os, some products of conception expelled, and some remain. Type of miscarriage. - Answer-incomplete abortion .Vaginal bleeding, closed cervical os, products of conception complete expelled. type of miscarriage. - Answer-complete abortion .risk factor for spontaneous abortion (pregnancy loss 20wks)? - Answer-Advanced maternal age due to associated risk of fetal chromosomal abnormalities, previous spontaneous abortion, substance abuse. Tx: 1. Expectant 2. Medical Induction (Misoprostol) 3. Suction Curettage (Infection or hemodynamic instability-hypotensive, tachycardia,anemia from acute blood loss)

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Uploaded on
October 29, 2025
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2025/2026
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USMLE STEP 2 QUESTIONS AND
OUTLINED ANSWERS || CLINICAL
KNOWLEDGE || SKILLS || CLINICAL
SCIENCE || ALL TESTED QUESTIONS



\.Obese Child

with dull hip PAIN or referred knee pain and a painful limp

with restricted ROM and inability to bear weight

on exam has limited rotation and abduction of the hip



Diagnosis & Tx? - Answer-Slipped Capital Femoral Epiphysis



requires immediate surgical screw fixation to reduce risk of AVN



\.chronic, progressive leg pain and limp in a 3-12 yo Boy

Limited abduction and internal rotation. Atrophy of proximal thigh muscles.



Diagnosis & Tx? - Answer-Legg-Calve-Perthes Disease or Idiopathic Osteonecrosis (avascular
necrosis) of the femoral epiphysis.



-Flattened and fragmented femoral head on radiograph



Tx:

,Mild: Observation

Moderate: bracing, hip abduction with a petrie cast

Extensive: osteotomy



\.fall in systemic arterial pressure by more than 10mmHg during inspiration. What is it? and
what cardiac problem is it associated with? - Answer-pulsus paradoxus



-Associated with cardiac Tamponade

-Becktriad can diagnose acute cardiac tamponade:

1. JVD (Kussmaul sign (increased JVD on inspiration))

2. Hypotension

3. Distant heart sounds



fluid accumulation in pericardial cavity increases intrapericardial pressure restricting venous
return to the heart lowering R & L ventricular filling. Net result = Decreased Preload, Stroke
Volume , Cardiac output.



\.Pulsus Parvus (decreased pulse amplitude) and Pulsus Tardus (delayed pulse upstroke)

(weak,delayed carotid upstroke) and a single or paradoxically split S2 sound;

systolic murmur radiating to the carotids.



associated with what cardiac defect? - Answer-aortic stenosis



Most common causes:

1. senile calcific aortic stenosis (Elderly)

2. bicuspid aortic valve (<70 yo)

3. rheumatic heart disease

,high resistance generated by stenosed aortic valve causes concentric hypertrophy and stiffening
of the left ventricle (S4) leading to CHF.



\.Bounding or "water hammer" pulses, with widened pulse pressure and head bob with
heartbeat are associated with what cardiac defect? Common etiologies? Treatment? - Answer-
aortic regurgitation



-Congenital Bicuspid Aortic Valve, Rheumatic Heart Disease, Endocarditits, Aortic Root Dilation
(Marfan, Syphilis)



-tx: Vasodilator therapy (dihydropyridines or ACEIs) for isolated aortic regurgitation until
symptoms become severe enough to warrant valve replacement.



\.Acute popping sensation in knee with catching, and locking, and slow onset joint effusion.
patient complains of sensation of instability. with joint line tenderness on exam.



What is the problem, Diagnosis, and management? - Answer-meniscal tear



-MRI for diagnosis



-Mild, older patient: REST, NSAID

-Impaired activity, young: SURGERY



\.postprandial pain, vomiting with early satiety. Abdominal succussion splash. Patient ingested
acid 3 months ago.



diagnosis? common causes? - Answer-Pyloric stricture

, -Upper Endoscopy required to confirm diagnosis and treatment is surgical.



-Common causes of GASTRIC OUTLET OBSTRUCTION: Gastric malignancy, PUD, Crohns,
Strictures from caustic ingestion, gastric bezoars.



\.Chronic nausea, vomiting and early satiety in a chronic diabetic.



What is the diagnosis? How is it treated? - Answer-diabetic gastroparesis



-Treat with pro-motility agent such as metoclopramide, exercise, and low fat diet

-Gastric Emptying study would be helpful in evaluating



\.Adolescent with progressive gait instability, dysarthria, wide based gait, marked atrophy of
medulla and dorsal columns of the spinal cord (loss of vibration and position sense), and
scoliosis.



What is the diagnosis? Risk of mortality? - Answer-Friedreich's ataxia



-AR (loss of function trinucleotide repeat (GAA) in Frataxin gene

-Mortality due to cardiac dysfunction (hypertrophic cardiomyopathy)



Genetic testing required to confirm diagnosis.

Management is supportive as no disease modifying therapies are available.



\.Child with conjunctival injection, watery discharge, tarsal inflammation, and pale follicles. As
well as rhinorrhea, Pharyngitis.

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