,Answers at the end of the Chapter nB nB nB nB nB nB nB
Chapter 1: Changes withAging nB nB nB nB
Multiple Choice nB
Identify the choice that best completes the statement or answers the question.
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1. The major impact of the physiological changes that occur with aging is:
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A. Reducedphysiological reserve nB nB
B. Reduced homeostatic mechanisms nB nB
C. Impaired immunological response nB nB
D. All of the above
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2. The strongest evidence regarding normal physiological aging is available through:
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,A. Randomized controlledclinicaltrials nB nB nB
B. Cross-sectional studies nB
C. Longitudinalstudies nB
D. Casecontrol studies nB nB
3. All of the following statements are true about laboratory
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values in older adultsexcept: nB nB nB
A. Referenceranges arepreferable n
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B. Abnormal findings areoften due to physiological aging
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C. Normal ranges may not be applicable for older adults
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D. Referencevalues arenot necessarily acceptable valuesnB nB nB nB nB nB
n B nB n B 4. Biochemical individuality is best described as:
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A. Each individual’s variationis often much greater than that of a larger group
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B. Theunique biochemical profile of a selected population
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C. Thetruly “normal” individual—falling within average range
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D. Each individual’s variationis often much smaller than that of a larger group
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n B nB n B 5. Polypharmacy is best described as taking:
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A. Morethan nine medications per day
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B. Morethan five medications per day
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, C. Even a single medication if thereis not a clear indication for its use
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D. When a drug is given to treat the side effect of another drug
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n B nB n B 6. Pharmacokinetic changes with aging is reflective of:
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A. What the drug does to the body
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B. What the body does to the drug
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C. The effect at the site of action and the time and intensity of the drug
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D. Theside effects commonly associated with the drug
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n B nB n B 7. All the following statements are false about drug absorption except:
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A. Antacids increasethe bioavailability of digitalis nB nB nB nB nB
B. Gastric acidity decreases with age nB nB nB nB
C. Anticholinergics increasecolonic motility nB nB nB
D. Underlying chronic disease has littleimpact on drug absorptionnB nB nB nB nB nB nB nB
8. All of the following statements are true about drug distribution in the
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elderly except: nB
A. Drugs distributedin water have lower concentration
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B. Drugs distributed in fat have less intense, more prolonged effect
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C. Drugs highly protein bound have greater potential to causean adverse drug reaction
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