Questions and Answers | A+ Score
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Schedule I - 🧠 ANSWER ✔✔Drugs in this schedule have no accepted
medical use in the United States and have a high abuse potential.
Examples are heroin, marijuana, LSD, peyote, etc.
Schedule II - 🧠 ANSWER ✔✔Drugs in this schedule have a high abuse
potential with severe psychic or physical dependence liability. Included are
certain narcotic analgesics, stimulants, and depressant drugs.
Examples are opium, morphine, codeine, hydromorphone, methadone,
meperidine, oxycodone, anileridine, cocaine, amphetamine,
,methamphetamine, phenmetrazine, methylphenidate, amobarbital,
pentobarbital, secobarbital, methaqualone, and phencyclidine.
Schedule III - 🧠 ANSWER ✔✔Drugs in this schedule have an abuse
potential less than those in Schedules I and II and include compounds
containing limited quantities of certain narcotic analgesic drugs, and other
drugs such as barbiturates, glutethimide, methyprylon, and
chlorphentemine.
Any suppository dosage form containing amobarbital, secobarbital, or
pentobarbital is in this schedule.
Schedule IV - 🧠 ANSWER ✔✔Drugs in this schedule have an abuse
potential less than those listed in Schedule III and include such drugs as
barbital, phenobarbital, chloral hydrate, ethchlorvynol, meprobabmate,
chlordizepoxide, diazepam, oxazepam, chloroazepate, flurazepam, etc.
Schedule V - 🧠 ANSWER ✔✔Drugs in this schedule have an abuse
potential less than those listed in Schedule IV and consist primarily of
preparations containing limited quantities of certain narcotic analgesic
drugs used for antitussive and antidiarrheal purposes.
,Absorption - 🧠 ANSWER ✔✔Process of drug movement from its site of
administration into the blood
Most common mechanism for drug absorption - 🧠 ANSWER ✔✔passive
diffusion
First-pass effect
(presystemic metabolism) - 🧠 ANSWER ✔✔Rapid hepatic inactivation of
certain oral drugs
drug is metabolized (chemically altered) as it passes through either 1) gut
wall, and 2) liver.
Distribution - 🧠 ANSWER ✔✔drug movement from the blood to the
interstitial space of tissues and from there into cells
Barriers to distribution - 🧠 ANSWER ✔✔- Blood brain barrier
- Placenta
Physiologic Factors Affecting Distribution - 🧠 ANSWER ✔✔- Perfusion
- Binding of drug to plasma protein
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, - Specialized Distribution Barriers
Albumin - 🧠 ANSWER ✔✔Binds acidic drugs
Protein (albumin) binding - 🧠 ANSWER ✔✔Prevents bound drug molecules
from leaving the bloodstream
Prolongs the distribution phase (Increases half-life)
alpha-1 acid glycoprotein - 🧠 ANSWER ✔✔Binds basic drugs
Reservoir effect - 🧠 ANSWER ✔✔
Blood-Brain Barrier (BBB) - 🧠 ANSWER ✔✔no intercellular pores between
brain capillary endothelial membranes due to the presence of tight
junctions between cells
To gain access to the brain from the capillaries, drugs must - 🧠 ANSWER
✔✔1) diffuse across cells (lipid-soluble,
nonionized form)
or