STUDENT C O M P A N I O N
F U N D A M
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E N T A L S O F
Biochemistry
LIFEAT b
THE MOLECULAR
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Voet Voet Pratt
F O U R T H E D I T I O N
Akif Uzman Jerry Johnson Joseph Eichberg William Widger
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FUNDAMENTALS OF b
BIOCHEMISTRY
LIFE AT THE MOLECULAR LEVEL
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UniversityofHouston b b
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UniversityofHouston b b
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CoverIllustrationNormChristiansen
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(Vitruvian Man): © Odysseus/Alamy and © Dennis Hallinan/Alamy b b b b b b b
Molecular structures clockwise from top: based on X-ray structures that were respectively determined by
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Richard Dickerson and Horace Drew, Caltech; Gerard Bunick, University of Tennessee; Thomas Steitz, Yale
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University; Alfonso Mondragón, Northwestern University; Venki Ramakrishnan, MRC Laboratory of
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Molecular Biology, Cambridge, U.K.; Andrew Leslie and John Walker, MRC Laboratoryof Molecular
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Biology, Cambridge, U.K.
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Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and understanding for more
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than 200 years, helping people around the world meet their needs and fulfill their aspirations. Our company is
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To order books or for customer service, please call 1-800-CALL WILEY (225-5945).
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StudentCompanion (paperback) b b ISBN-13 978-1-1182-1827-3 b
Printed in the United States of America10 b b b b b b b
b 987 654 321
b b b b b b b b
F U N D A M
b
E N T A L S O F
Biochemistry
LIFEAT b
THE MOLECULAR
b
LEVEL b
Voet Voet Pratt
F O U R T H E D I T I O N
Akif Uzman Jerry Johnson Joseph Eichberg William Widger
b b b b
Donald Voet Judith G. Voet CharlotteW.Pratt
b b b b b b
,This page is intentionally left blank
b b b b b
,STUDENT COMPANIONTO ACCOMPANY b b b
FUNDAMENTALS OF b
BIOCHEMISTRY
LIFE AT THE MOLECULAR LEVEL
b b b b
FourthEdition b
AkifUzman
b
UniversityofHouston b b
JerryJohnsonb
UniversityofHouston b b
JosephEichberg b
UniversityofHouston b b
William Widger b
UniversityofHouston b b
DonaldVoet b
UniversityofPennsylvania b b
Judith G. Voet b b
SwarthmoreCollege b
Charlotte W. Pratt b b
Seattle,Washington b
JOHN WILEY & SONS, INC
b b b b
, Cover Designer Madelyn Lesure b b b
CoverIllustrationNormChristiansen
b b b b
Cover Photos
b b
(Vitruvian Man): © Odysseus/Alamy and © Dennis Hallinan/Alamy b b b b b b b
Molecular structures clockwise from top: based on X-ray structures that were respectively determined by
b b b b b b b b b b b b b
Richard Dickerson and Horace Drew, Caltech; Gerard Bunick, University of Tennessee; Thomas Steitz, Yale
b b b b b b b b b b b b b b
University; Alfonso Mondragón, Northwestern University; Venki Ramakrishnan, MRC Laboratory of
b b b b b b b b b b
Molecular Biology, Cambridge, U.K.; Andrew Leslie and John Walker, MRC Laboratoryof Molecular
b b b b b b b b b b b b b
Biology, Cambridge, U.K.
b b b
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and understanding for more
b b b b b b b b b b b b b b b b b b
than 200 years, helping people around the world meet their needs and fulfill their aspirations. Our company is
b b b b b b b b b b b b b b b b b b
built on a foundation of principles that include responsibility to the communities we serve andwhere we live and
b b b b b b b b b b b b b b b b b b b
work. In 2008, we launched a Corporate Citizenship Initiative, a global effort to address the environmental,
b b b b b b b b b b b b b b b b
social, economic, and ethical challenges we face in our business. Among the issues we are addressing are carbon
b b b b b b b b b b b b b b b b b b
impact, paper specifications and procurement, ethical conduct within our business and among our vendors, and
b b b b b b b b b b b b b b b
community and charitable support. For more information, please visit our website:
b b b b b b b b b b b
www.wiley.com/go/citizenship.
b
Copyright © 2012 b b John Wiley & Sons, Inc. b b b b
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in
b b b b b b b b b b b b b b b b b b
any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except as
b b b b b b b b b b b b b b b
permitted under Sections 107 or 108 of the 1976 United States Copyright Act, without either the prior written
b b b b b b b b b b b b b b b b b b
permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright
b b b b b b b b b b b b b b b b
Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, website www.copyright.com. Requests to
b b b b b b b b b b b b b
the Publisher for permission should be addressed to thePermissions Department, John Wiley & Sons, Inc. 111
b b b b b b b b b b b b b b b b b
River Street, Hoboken, NJ 07030-5774, (201) 748-6011, fax (201) 748-6008, website
b b b b b b b b b b b
http://www.wiley.com/go/permissions.
b
To order books or for customer service, please call 1-800-CALL WILEY (225-5945).
b b b b b b b b b b b
StudentCompanion (paperback) b b ISBN-13 978-1-1182-1827-3 b
Printed in the United States of America10 b b b b b b b
b 987 654 321
b b b b b b b b