NRSG 3100 - Exam 6 (Units 12 and 13 NRSG 3100 - Exam
#6) Questions With Complete Solutions
Natural Products
MOA: from periwinkle plant, works only in the M phase of the
cell cycle; inhibits division
- For intravenous use only fatal if given intrathecally
Indications: Approved to treat acute lymphocytic leukemia,
Hodgkin’s and non-Hodgkin’s lymphomas, and many more (see
p. 1057-1058 for all the indications)
Drug Interactions: Concurrent administration with mitomycin
(antitumor antibiotic) may cause acute dyspnea and severe
bronchospasm; neurotoxicity may occur with peripheral nervous
system drugs
Route: Only given IV. Has caused fatalities when given
intrathecally
Adverse Effects:
–Toxic effects even at a therapeutic dose
–Neurotoxicity is the major dose-limiting toxicity
•Motor difficulties, severe and often permanent peripheral
neuropathies, paresthesias, weakness, nerve palsies, and
decreased reflexes
•CNS effects may include seizures, depression, hallucinations,
and coma
,•GI toxicity includes N/V, anorexia, stomatitis, severe
constipation, abdominal pain, hepatotoxicity, and paralytic ileus
•Rash and alopecia
Black Box Warning
–Myelosuppression may be severe
–If extravasation occurs, treat with warm compresses and
hyaluronidase
–Cold packs will significantly increase the toxicity of vinca
alkaloids
Contraindications: People of childbearing age, active infection;
pregnancy, lactation; caution with leukopenia, other drugs with
neurotoxic properties
What drug is this?
Vincristine
Cancer Treatment
Major modalities of treatment:
•Surgery- ______
•Chemotherapy- _______ (Unit 12)
•Radiation Therapy- local or systemic (Unit 13)
•Emerging fields: Immunotherapy and Targeted Cell
Therapy (Unit 13)
,–Includes: Monoclonal antibodies, Non-specific
immunotherapies, Oncolytic virus therapy, T-cell therapy and
Cancer vaccines
•_____ Marrow Transplant (NRSG 3200)
local
systemic
bone
Radiation Therapy
Used to cure, control spread, or for palliative care
•Adjunct to surgery and chemotherapy
•______ tumor prior to surgical removal
•Relieve symptoms caused by a _______ tumor/mass
All cells are susceptible to the effects of radiation during cell
growth, but _____-growing tissues are most susceptible
_______ marrow
•Lymphatic tissue
•_____ tract epithelium
•________
•Skin (including hair and nails)
shrink
large
fast
bone
, GI
Gonad
Radiation Therapy
•____-____% of cancer patients get radiation as part of their
treatment protocol
•Has become extremely advanced in recent years
•Types of radiation
-External
-Internal (__________)
-________ (by mouth or IV)
•Radiation team involved in decision-making includes:
Radiation Oncologist, Radiation Physicist Dosimetrist, Rad
Therapy Tech, Rad Therapy RN
50-60%
brachytherapy
systemic
Radiation Therapy
•Directly or indirectly _________. Thought to be effective
through breaking up double-strand nuclear DNA
•Dose is dependent on sensitivity and _____ of the tumor
•Total radiation dose is often delivered over several weeks/many
treatments for greater cell kill by exposing more cells to
radiation as they begin ______ cell division
•Treatment over time will also increase tumor ________ to
#6) Questions With Complete Solutions
Natural Products
MOA: from periwinkle plant, works only in the M phase of the
cell cycle; inhibits division
- For intravenous use only fatal if given intrathecally
Indications: Approved to treat acute lymphocytic leukemia,
Hodgkin’s and non-Hodgkin’s lymphomas, and many more (see
p. 1057-1058 for all the indications)
Drug Interactions: Concurrent administration with mitomycin
(antitumor antibiotic) may cause acute dyspnea and severe
bronchospasm; neurotoxicity may occur with peripheral nervous
system drugs
Route: Only given IV. Has caused fatalities when given
intrathecally
Adverse Effects:
–Toxic effects even at a therapeutic dose
–Neurotoxicity is the major dose-limiting toxicity
•Motor difficulties, severe and often permanent peripheral
neuropathies, paresthesias, weakness, nerve palsies, and
decreased reflexes
•CNS effects may include seizures, depression, hallucinations,
and coma
,•GI toxicity includes N/V, anorexia, stomatitis, severe
constipation, abdominal pain, hepatotoxicity, and paralytic ileus
•Rash and alopecia
Black Box Warning
–Myelosuppression may be severe
–If extravasation occurs, treat with warm compresses and
hyaluronidase
–Cold packs will significantly increase the toxicity of vinca
alkaloids
Contraindications: People of childbearing age, active infection;
pregnancy, lactation; caution with leukopenia, other drugs with
neurotoxic properties
What drug is this?
Vincristine
Cancer Treatment
Major modalities of treatment:
•Surgery- ______
•Chemotherapy- _______ (Unit 12)
•Radiation Therapy- local or systemic (Unit 13)
•Emerging fields: Immunotherapy and Targeted Cell
Therapy (Unit 13)
,–Includes: Monoclonal antibodies, Non-specific
immunotherapies, Oncolytic virus therapy, T-cell therapy and
Cancer vaccines
•_____ Marrow Transplant (NRSG 3200)
local
systemic
bone
Radiation Therapy
Used to cure, control spread, or for palliative care
•Adjunct to surgery and chemotherapy
•______ tumor prior to surgical removal
•Relieve symptoms caused by a _______ tumor/mass
All cells are susceptible to the effects of radiation during cell
growth, but _____-growing tissues are most susceptible
_______ marrow
•Lymphatic tissue
•_____ tract epithelium
•________
•Skin (including hair and nails)
shrink
large
fast
bone
, GI
Gonad
Radiation Therapy
•____-____% of cancer patients get radiation as part of their
treatment protocol
•Has become extremely advanced in recent years
•Types of radiation
-External
-Internal (__________)
-________ (by mouth or IV)
•Radiation team involved in decision-making includes:
Radiation Oncologist, Radiation Physicist Dosimetrist, Rad
Therapy Tech, Rad Therapy RN
50-60%
brachytherapy
systemic
Radiation Therapy
•Directly or indirectly _________. Thought to be effective
through breaking up double-strand nuclear DNA
•Dose is dependent on sensitivity and _____ of the tumor
•Total radiation dose is often delivered over several weeks/many
treatments for greater cell kill by exposing more cells to
radiation as they begin ______ cell division
•Treatment over time will also increase tumor ________ to
