chapter 26: narcotics, narcotic
antagonists and anti-migraine agents
Questions And Verified Answers.
Large diameter nerves - Answer A fibers transmit sensations associated with touch and temp
large fibers conduct impulses more rapidly than smaller fibers
large fibers block ability of smaller fibers to transmit their signals
drugs used to relieve pain... - Answer narcotics
antimigraine drugs
gate-control theory - Answer sensory and emotional experience
transmission of these impulses can be modulated or adjusted
interneurons can act as gates
several factors can activate the descending inhibitory nerves from the upper CNS
Tissue injury causes the release of - Answer bradykinin, histamine, potassium, prostaglandins,
serotonin
These fibers produce pain sensatinos - Answer A delta fibers
C fibers
Pain fibers enter the spinal cord and .... - Answer travel up to the brain
the point of spinal cord entry is the ... - Answer dorsal horn "the gate"
the gate regulates the flow of sensory impulse to the brain
activation of large diameter A fibers... - Answer close the gate
, control the gate before the gate is open
enkephalins and endorphins - Answer Endogenous neurotransmitters which bind to opioid
receptors to fight pain.
inhibit transmission of pain by closing gate
Location of opioid receptors - Answer CNS, nerves in the periphery, cells in the GI tract
Narcotic agonists actions - Answer act as specific opioid receptor sites in the CNS
produce analgesia, sedation and sense of well being
potential for physical dependance
Narcotic Antagonist indications - Answer relief of severe, acute or chronic pain
analgesia during anesthesia
antitussives
adjuncts to general anethesia
antitussives/expectorants - Answer control cough, promote elimination of mucus
narcotic agonists pharmacokinetics - Answer -IV most reliable way to achieve therapeutic
response
-IM and sub-q rate of absorption varies
-Hepatic metabolism and generally excreted in the urine and bile
Narcotic agonists contraindications - Answer Known allergy
Pregnancy, labor, lactation
Diarrhea caused by poisons
biliary surgery
narcotic agonists caution - Answer respiratory dysfunction
recent GI or urinary surgery
head injuries or alcoholism