ANCC Acute Care Nurse Practitioner
(ACNP) Board Exam Review
Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
A 68-year-old male with COPD presents with increasing dyspnea and productive cough. Which
test is most appropriate to evaluate for an acute exacerbation?
A. Chest CT scan
✔✔B. Chest X-ray
C. Pulmonary angiogram
D. Echocardiogram
Which of the following electrolyte abnormalities is most likely to cause peaked T waves on an
EKG?
A. Hypocalcemia
B. Hypomagnesemia
✔✔C. Hyperkalemia
D. Hyponatremia
1
,A patient with suspected sepsis is hypotensive after receiving 30 mL/kg fluid resuscitation. What
is the next best step in management?
A. Start oral antibiotics
✔✔B. Initiate vasopressors
C. Order repeat urinalysis
D. Wait for blood culture results
Which of the following antibiotics is most appropriate for initial empiric therapy in hospital-
acquired pneumonia?
A. Amoxicillin
✔✔B. Piperacillin-tazobactam
C. Azithromycin
D. Cephalexin
In a patient with a deep vein thrombosis (DVT), which of the following findings supports the
diagnosis of a pulmonary embolism?
✔✔A. Sudden-onset dyspnea and pleuritic chest pain
B. Gradual-onset abdominal pain
C. Bradycardia and hypothermia
2
, D. Productive cough with green sputum
Which of the following is a common side effect of amiodarone?
✔✔A. Pulmonary fibrosis
B. Hypertension
C. Hypoglycemia
D. Liver failure within 24 hours
A patient with heart failure has an ejection fraction of 25%. Which medication improves
survival?
A. Furosemide
✔✔B. Lisinopril
C. Digoxin
D. Acetaminophen
A 45-year-old female presents with confusion, fever, and a stiff neck. What is the most
appropriate initial diagnostic test?
✔✔A. Lumbar puncture
3
(ACNP) Board Exam Review
Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
A 68-year-old male with COPD presents with increasing dyspnea and productive cough. Which
test is most appropriate to evaluate for an acute exacerbation?
A. Chest CT scan
✔✔B. Chest X-ray
C. Pulmonary angiogram
D. Echocardiogram
Which of the following electrolyte abnormalities is most likely to cause peaked T waves on an
EKG?
A. Hypocalcemia
B. Hypomagnesemia
✔✔C. Hyperkalemia
D. Hyponatremia
1
,A patient with suspected sepsis is hypotensive after receiving 30 mL/kg fluid resuscitation. What
is the next best step in management?
A. Start oral antibiotics
✔✔B. Initiate vasopressors
C. Order repeat urinalysis
D. Wait for blood culture results
Which of the following antibiotics is most appropriate for initial empiric therapy in hospital-
acquired pneumonia?
A. Amoxicillin
✔✔B. Piperacillin-tazobactam
C. Azithromycin
D. Cephalexin
In a patient with a deep vein thrombosis (DVT), which of the following findings supports the
diagnosis of a pulmonary embolism?
✔✔A. Sudden-onset dyspnea and pleuritic chest pain
B. Gradual-onset abdominal pain
C. Bradycardia and hypothermia
2
, D. Productive cough with green sputum
Which of the following is a common side effect of amiodarone?
✔✔A. Pulmonary fibrosis
B. Hypertension
C. Hypoglycemia
D. Liver failure within 24 hours
A patient with heart failure has an ejection fraction of 25%. Which medication improves
survival?
A. Furosemide
✔✔B. Lisinopril
C. Digoxin
D. Acetaminophen
A 45-year-old female presents with confusion, fever, and a stiff neck. What is the most
appropriate initial diagnostic test?
✔✔A. Lumbar puncture
3
