EXAM AND COMPLETE QUESTIONS AND ANSWERS | 100% RATED
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What is the drug of choice for stage A heart failure - (ANSWER)ACEs
What medication is considered in Stage A heart failure but is more expensive than ACEs -
(ANSWER)ARBs
What drugs will you see in most stage B heart failure patients - (ANSWER)Beta blockers
What medications will you see in all stage b heart failure patients - (ANSWER)ACEs
What drugs will you see in Stage B heart failure patients who cannot tolerate ACEs -
(ANSWER)ARBs
What medications will you see in all stage c heart failure patients (5) - (ANSWER)ACESs
BBs
Diuretics
Digoxin
Spironolactone
What medications will you see in stage D heart failure (5) - (ANSWER)Sacubitril
,Valsartan (Entresto)
ACEs
ARBs
Inotropes: dobutamine
Ventricular assisting devices
Transplantation
Hospice
Pharmacodynamics of ACEs - (ANSWER)Inhibit angiotensin-converting enzyme (ACE) which
results in decreased production of both angiotensin II and aldosterone
What are the special characteristics of ACEs - (ANSWER)Can lower vascular resistance without
decreasing cardiac output (CO) or glomerular filtration rate (GFR)
Does not produce reflex tachycardia
Uses for ACEs - (ANSWER)Strong evidence for CV and cerebrovascular risk reduction, heart
failure, and slowing renal disease
Outcomes of ACEs on the heart - (ANSWER)Improves oxygenation to heart muscle, decreases
inappropriate remodeling of heart muscle after MI or with HF, reduces effects of diabetes on the
kidneys
,Outcomes of ACEs on insulin - (ANSWER)Improves insulin sensitivity, does not affect glucose
metabolism or raise serum lipid levels
Outcomes of ACEs in patients with angina - (ANSWER)Prevents formation of AT II and
decreases pulmonary vascular resistance by decreasing retention of sodium and water and
reducing extracellular fluid and preload
Outcomes of ACEs in patients with diabetes - (ANSWER)Prevents slow nephropathy
Outcomes of ACEs in patients after an MI and HF - (ANSWER)Promotes ventricular remodeling
True or false
ACEs are equally effective in all races - (ANSWER)False
Not as effective in African Americans
How do you increase the effects of ACEs in the African American population -
(ANSWER)Combine with a diuretic
What is the biggest risk with ACEs in AA and Asian populations - (ANSWER)3-4 times greater
risk of angioedema
ACE ADRs - (ANSWER)Dry cough (bradykinin mediated)
Hypotension
Loss of taste
, Angioedema
Blood dycrasias
Teratogenicity
Hyperkalemia
Acute renal failure
Cholestatic jaundice
Pancreatitis
Rash
ACE monitoring - (ANSWER)Possible orthostasis within 1 hour of administration when starting
and with each dosage change
ACE patient education - (ANSWER)Do not double dose if one is missed
Hypotension
Cough is common with the older generation
Angiotensin II Receptor blocker MOA - (ANSWER)Prevent the binding of AT II to receptors in
the kidneys, brain, heart, and arterial walls