Correct
How fast to taper buprenorphine? - ANSWER Fast tapers are associated with high
rates of relapse. Taper slow, if at all. Considered long-term maintenance treatment.
Naltrexone works how? - ANSWER Blocks the mu receptors so they can not be
stimulated.
Mu receptors are located: - ANSWER In the brain and CNS, also intestines, hence
while people get constipated on opioids.
Mu receptors gets its name from: - ANSWER Mu is the Greek letter M and these
receptors received their name due to studies involving the mechanism of morphine.
Mu receptors are responsible for: - ANSWER pain relief and pleasure response to
opioids.
Naltrexone comes as: - ANSWER Naltrexone tablets, Revia tablets & Vivitrol injection.
How often do you have to take Naltrexone? - ANSWER Daily or sometimes 3 x week.
The patient must be an active participant.
Vivitrol injection is taken ow often? - ANSWER Injection given once monthly. If the
patient seeks to abuse drugs, it will be fruitless as the Mu receptors are blocked.
Cravings for alcohol are also reduced with this.
Which drugs are commonly used for Alcohol use disorder? - ANSWER Disulfiram
(Antabuse)
Acamprosate
Naltrexone
What kind of therapy is Disulfiram? - ANSWER Aversion therapy.
If alcohol is consumed while taking, the patient ill have unpleasant side effects. This
leads to negative conditioning.
Disulfiram is used to treat? - ANSWER Chronic alcoholism. Most effective in people
who have already gone through detoxification or are in the iitial stage of abstinence.
,How often to take Disulfiram and how long after alcohol? - ANSWER 1. Once a day
tablet form.
2. Should never be taken while intoxicated and should not be taken for at least 12
hours after drinking alcohol.
Dangerous side effect of Disulfiram? - ANSWER alcohol toxicity is patient does not
abstain from alcohol.
Unpleasant side effects of Disulfiram? - ANSWER Nausea, headache, vomiting, chest
pains, difficulty breathing. Can occur as soon as 10 minute after drinking even a small
amount o alcohol and can last for an hour or more.
Acamprosate (Campral) works by: - ANSWER Decreases cravings.
Sometimes referred to as artificial alcohol. Good for people who have already stopped
drinking and want ot avoid drinking.
Use of Acamprosate usually begins when? - ANSWER on 5th day of abstinence and
reaches full effectiveness in 5-8 days.
How often is Acamprosate taken? - ANSWER 3 times a day.
SE of Acamprosate: - ANSWER diarrhea, upset stomach, appetite loss, anxiety,
dizziness and difficulty sleeping.
Acamprosate is a good choice for those who? - ANSWER have recently abstained
from alcohol. No labs needed.
What labs would you get before starting Disulfiram? - ANSWER LFT's at baseline and
follow up.
What labs would you get before stating Naltrexone? - ANSWER LFT's, CBC. CMP, &
TSH.
Which works quickest Naltrexone or Disulfiram? - ANSWER Disulfiram
Naltrexone helps people with: - ANSWER alcohol addiction to reduce their drinking
behaviors enough to remain motivated to stay in treatment, avoid relapses and take
medications.
What other pharmacological interventions are used for AUD? - ANSWER 1.
Benzodiazepines for detox.
2. Anticonvulsants for prophylaxis.
,What med reverses benzodiazepines? - ANSWER Romazicon
Why is clonidine used for AUD treatment? - ANSWER control sympathetic nervous
system hyperactivity, not effective against seizures and delirium.
How do you treat delirium in AUD? - ANSWER Benzodiazepines every 2-4 hours.
50-100 mg chlordiazepoxide every 4 hours if IV lorazepam not possible.
Treatment for Wernicke's syndrome: - ANSWER Large doses of parenteral thiamine
(can include 100 mg in each liter of glucose) or 100 mg PO 2-3 x a day for 1-2 weeks
.
Korsakoff treatment: - ANSWER Same as Wernicke's but for 3-12 months.
Name some CNS stimulants: - ANSWER Cocaine, crack, amphetamines', meth,
caffeine and nicotine
Common signs of stimulant use are: - ANSWER 1. Dilation of pupils.
2. Dryness of oronasal cavity.
3. Excessive motor activity.
How fast doe crack work? - ANSWER It takes effect in 4-6 seconds, producing a
fleeting high in 5=7 minutes following a period of deep depression that reinforce
addictive behavior.
Signs of CNS stimulant intoxication: - ANSWER Tachycardia, dilated pupils, elevated
BP, N/V, insomnia, grandiosity, impaired judgement, restlessness & convulsions.
Club drug: ecstasy is? - ANSWER MDMA, class of substituted amphetamines that also
includes Molly or Love.
What effects does Ecstasy have? How do people feel? - ANSWER produces
subjective feeling that resemble stimulants or hallucinogens. Give outpouring or good
feelings about others & world around them.
Side effects of Ecstasy are? - ANSWER extremely sensitive, hyperactive,
inexhaustible energy, dilated pupils, impaired reaction to light; elevated temp, pulse
and BP; diaphoresis, and bruxism.
People on Ecstasy need? - ANSWER Lots of water. Or they will have dehydration and
hyperthermia.
, After ecstasy wears off, what happens? - ANSWER They go into a state of deep
depression lasting 3-4 days. Continued use depletes serotonin stores and it will not
produce the same effects.
Molly is? - ANSWER Purer version of MDMA. Usually sold in capsule, popular at
raves.
Molly usually has: - ANSWER other chemicals even though sold as 100%.
Hallucinogens: LSD, sx of intoxication: - ANSWER Pupil dilation, tachycardia,
diaphoresis, palpitations, tremors; elevated temp, pulse and respirations.
LSD psychological perception effects are? - ANSWER Fear of going crazy.
Paranoid ideas.
Marked anxiety and depression.
Synesthesia (colors seen or heard)
Depersonalization
Hallucinations
Grandiosity
PCP intoxication sx are? -
ANSWER Ataxia
muscle
rigidity
seizure
blank
stare
belligerence, assaultiveness and
impulsiveness.
Vertical or horizontal nystagmus, increased
BP, pulse and temp.
PCP psychological perceptual effects are? - ANSWER Hallucinations, paranoia
Bizarre behavior
Regressive behavior
Violent behavior
Synthetic cathinone (Bath salt) is? - ANSWER Psychoactive mind-altering substance.
Synthetic stimulant chemically related to a substance found in the khat plant (people
chew leaves in Africa for a mild stimulant effect).
Compared to cocaine, synthetic stimulants are? - ANSWER stronger and more
dangerous. Can be 10x more powerful than cocaine.