TIETZ FUNDAMENTALS OF CLINICAL CHEMISTRY AND
07/08/2
MOLECULAR DIAGNOSTICS 8TH EDITION
Complete Test Bank
Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics
8th Edition
(Nader Rifai ) latest edition 2025| Unit 1-5 | All chapters 1-49 (Q&A)
T T
E E
S S
T T
B B
A A
N N
K K
,TIETZ FUNDAMENTALS OF CLINICAL CHEMISTRY AND
07/08/2
MOLECULAR DIAGNOSTICS 8TH EDITION
Table of Contents
Unit 1: Principles Of Laboratory Medicine4
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine ...............................................................................................
Chapter 02: Selection andtAnalytical Evaluationof Methods— With StatisticaltTechniques .................................................................................
Chapter 03: ClinicaltEvaluationof Methods...............................................................................................................................................................
Chapter 04: Evidence-Based Laboratory Medicine .....................................................................................................................................................
Chapter 05: Establishmenttand Usetof ReferencetValue ..........................................................................................................................................
Chapter 06: Specimen Collection, Processing,tand Other PreanalyticaltVariables .....................................................................................................
Chapter07:Quality Management ...............................................................................................................................................................................
Unit 2: Analytical Techniques And Instrumentation
Chapter 08: Principlesof Basic Techniquesand Laboratory Safety ..........................................................................................................................
Chapter09:OpticaltTechniques ..................................................................................................................................................................................
Chapter10: ElectrochemistryandChemical Sensors ...................................................................................................................................................
Chapter11:Electrophoresis ........................................................................................................................................................................................
Chapter 12: Chromatography .........................................................................................................................................................................................
Chapter13:MassSpectrometry ....................................................................................................................................................................................
Chapter14: Enzymetand Rate Analyses .......................................................................................................................................................................
Chapter 15: ImmunochemicaltTechniques ......................................................................................................................................................................
Chapter16:Automation ..............................................................................................................................................................................................
Chapter17:Point-of- CaretInstrumentation...............................................................................................................................................................
Unit 3: Analytes
Chapter 18: AminotAcids, Peptides,tand Proteins ....................................................................................................................................................
Chapter19:SerumtEnzymes .......................................................................................................................................................................................
Chapter20: Tumor Markersand Cancer Genes ............................................................................................................................................................
Chapter 21: Kidney Function Tests— Creatinine, Urea, andtUrictAcid ......................................................................................................................
Chapter 22: Carbohydrates ........................................................................................................................................................................................
Chapter 23: Lipids, Lipoproteins, Apolipoproteins, andtOther CardiactRisk Factors ................................................................................................
Chapter24: ElectrolytesandBloodGases .....................................................................................................................................................................
Chapter 25: Hormones ...............................................................................................................................................................................................
Chapter26:CatecholaminesandtSerotonin ................................................................................................................................................................
Chapter27:Vitamins, TraceElements,tandNutritional Assessment ............................................................................................................................
Chapter 28: Hemoglobin, Iron, and Bilirubin .............................................................................................................................................................
Chapter29:PorphyrinsandPorphyriast ......................................................................................................................................................................
Chapter30:TherapeutictDrugsand TheirManagement ..............................................................................................................................................
Chapter 31: Clinical Toxicology ..................................................................................................................................................................................
Chapter 32: Toxic Metals .............................................................................................................................................................................................
Unit 4: Pathophysiology
Chapter33:Diabetes ....................................................................................................................................................................................................
,TIETZ FUNDAMENTALS OF CLINICAL CHEMISTRY AND
07/08/2
MOLECULAR DIAGNOSTICS 8TH EDITION
Chapter 34: Cardiovascular Disease ...........................................................................................................................................................................
Chapter35:KidneyDisease ..........................................................................................................................................................................................
Chapter36: Physiologyand Disorderstof Water, Electrolyte, and Acid- BaseMetabolism .............................................................................................
Chapter37:LiverDisease .............................................................................................................................................................................................
Chapter38:GastrointestinalandPancreatic Diseases..................................................................................................................................................
Chapter39: Disordersof Bone andtMineral Metabolism..............................................................................................................................................
Chapter40: DisordersofthetPituitary ..........................................................................................................................................................................
Chapter41: Disordersofthe AdrenaltCortex ................................................................................................................................................................
Chapter 42: Thyroid Disorders .......................................................................................................................................................................................
Chapter 43: Reproduction- Related Disorders .............................................................................................................................................................
Chapter44: PregnancyandtPrenatal Testing...............................................................................................................................................................
Chapter45: Newborn Screeningand Inborn Errorsof Metabolismt ..............................................................................................................................
Chapter 46: Pharmacogenetics .......................................................................................................................................................................................
Unit 5: Molecular Diagnostics
Chapter 47: PrinciplesofMolecular Biology ..............................................................................................................................................................
Chapter48:Nucleic Acid Techniquesand Applications ................................................................................................................................................
Chapter 49: Genomes andtNucleic Acid Alterations ....................................................................................................................................................
, TIETZ FUNDAMENTALS OF CLINICAL CHEMISTRY AND
07/08/2
MOLECULAR DIAGNOSTICS 8TH EDITION
Unit 1: Principles Of Laboratory Medicine
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative
who works for a company that sells chemistry laboratory supplies. When the laboratory
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
recommends the spouse’s company as the vendor. This is considered to be a(n):
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential
conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
the pain following her recent surgery. A friend of the patient claims that the same painkiller
“worked wonders” to reduce her pain after the same surgery. The physician states that the
difference in the effect of the drug might be caused by , which is studied in
pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between
individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
name of a close friend printed on the bar-coded label. The genetic test that is ordered on the
friend’s sample would provide diagnostic information about a disorder that has a poor
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
the sample for him and not divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
d. diagnostic accuracy.
07/08/2
MOLECULAR DIAGNOSTICS 8TH EDITION
Complete Test Bank
Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics
8th Edition
(Nader Rifai ) latest edition 2025| Unit 1-5 | All chapters 1-49 (Q&A)
T T
E E
S S
T T
B B
A A
N N
K K
,TIETZ FUNDAMENTALS OF CLINICAL CHEMISTRY AND
07/08/2
MOLECULAR DIAGNOSTICS 8TH EDITION
Table of Contents
Unit 1: Principles Of Laboratory Medicine4
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine ...............................................................................................
Chapter 02: Selection andtAnalytical Evaluationof Methods— With StatisticaltTechniques .................................................................................
Chapter 03: ClinicaltEvaluationof Methods...............................................................................................................................................................
Chapter 04: Evidence-Based Laboratory Medicine .....................................................................................................................................................
Chapter 05: Establishmenttand Usetof ReferencetValue ..........................................................................................................................................
Chapter 06: Specimen Collection, Processing,tand Other PreanalyticaltVariables .....................................................................................................
Chapter07:Quality Management ...............................................................................................................................................................................
Unit 2: Analytical Techniques And Instrumentation
Chapter 08: Principlesof Basic Techniquesand Laboratory Safety ..........................................................................................................................
Chapter09:OpticaltTechniques ..................................................................................................................................................................................
Chapter10: ElectrochemistryandChemical Sensors ...................................................................................................................................................
Chapter11:Electrophoresis ........................................................................................................................................................................................
Chapter 12: Chromatography .........................................................................................................................................................................................
Chapter13:MassSpectrometry ....................................................................................................................................................................................
Chapter14: Enzymetand Rate Analyses .......................................................................................................................................................................
Chapter 15: ImmunochemicaltTechniques ......................................................................................................................................................................
Chapter16:Automation ..............................................................................................................................................................................................
Chapter17:Point-of- CaretInstrumentation...............................................................................................................................................................
Unit 3: Analytes
Chapter 18: AminotAcids, Peptides,tand Proteins ....................................................................................................................................................
Chapter19:SerumtEnzymes .......................................................................................................................................................................................
Chapter20: Tumor Markersand Cancer Genes ............................................................................................................................................................
Chapter 21: Kidney Function Tests— Creatinine, Urea, andtUrictAcid ......................................................................................................................
Chapter 22: Carbohydrates ........................................................................................................................................................................................
Chapter 23: Lipids, Lipoproteins, Apolipoproteins, andtOther CardiactRisk Factors ................................................................................................
Chapter24: ElectrolytesandBloodGases .....................................................................................................................................................................
Chapter 25: Hormones ...............................................................................................................................................................................................
Chapter26:CatecholaminesandtSerotonin ................................................................................................................................................................
Chapter27:Vitamins, TraceElements,tandNutritional Assessment ............................................................................................................................
Chapter 28: Hemoglobin, Iron, and Bilirubin .............................................................................................................................................................
Chapter29:PorphyrinsandPorphyriast ......................................................................................................................................................................
Chapter30:TherapeutictDrugsand TheirManagement ..............................................................................................................................................
Chapter 31: Clinical Toxicology ..................................................................................................................................................................................
Chapter 32: Toxic Metals .............................................................................................................................................................................................
Unit 4: Pathophysiology
Chapter33:Diabetes ....................................................................................................................................................................................................
,TIETZ FUNDAMENTALS OF CLINICAL CHEMISTRY AND
07/08/2
MOLECULAR DIAGNOSTICS 8TH EDITION
Chapter 34: Cardiovascular Disease ...........................................................................................................................................................................
Chapter35:KidneyDisease ..........................................................................................................................................................................................
Chapter36: Physiologyand Disorderstof Water, Electrolyte, and Acid- BaseMetabolism .............................................................................................
Chapter37:LiverDisease .............................................................................................................................................................................................
Chapter38:GastrointestinalandPancreatic Diseases..................................................................................................................................................
Chapter39: Disordersof Bone andtMineral Metabolism..............................................................................................................................................
Chapter40: DisordersofthetPituitary ..........................................................................................................................................................................
Chapter41: Disordersofthe AdrenaltCortex ................................................................................................................................................................
Chapter 42: Thyroid Disorders .......................................................................................................................................................................................
Chapter 43: Reproduction- Related Disorders .............................................................................................................................................................
Chapter44: PregnancyandtPrenatal Testing...............................................................................................................................................................
Chapter45: Newborn Screeningand Inborn Errorsof Metabolismt ..............................................................................................................................
Chapter 46: Pharmacogenetics .......................................................................................................................................................................................
Unit 5: Molecular Diagnostics
Chapter 47: PrinciplesofMolecular Biology ..............................................................................................................................................................
Chapter48:Nucleic Acid Techniquesand Applications ................................................................................................................................................
Chapter 49: Genomes andtNucleic Acid Alterations ....................................................................................................................................................
, TIETZ FUNDAMENTALS OF CLINICAL CHEMISTRY AND
07/08/2
MOLECULAR DIAGNOSTICS 8TH EDITION
Unit 1: Principles Of Laboratory Medicine
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative
who works for a company that sells chemistry laboratory supplies. When the laboratory
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
recommends the spouse’s company as the vendor. This is considered to be a(n):
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential
conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
the pain following her recent surgery. A friend of the patient claims that the same painkiller
“worked wonders” to reduce her pain after the same surgery. The physician states that the
difference in the effect of the drug might be caused by , which is studied in
pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between
individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
name of a close friend printed on the bar-coded label. The genetic test that is ordered on the
friend’s sample would provide diagnostic information about a disorder that has a poor
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
the sample for him and not divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
d. diagnostic accuracy.
