TEST BANK FOR CLINICOPATHOLOGICAL FOUNDATIONS OF MEDICINE 7TH EDITION BY David S. Strayer, Emanuel Rubin . ISBN:978-1451183900 FULL GUIDE FOR A+ GRADE!!

Rubin's Pathology: Clinicopathologic Foundations of Medicine Testba
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nk/Studyguide
Chapter 1: Cell Adaptation, Injury and Death
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Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a result
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1. of:
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A) release of stored calcium from the mitochondria.
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B) improved intracellular volume regulation. qw qw qw




C) decreased influx across the cell membrane. qw qw qw qw qw




D) attraction of calcium to fatty infiltrates.
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The patient is found to have liver disease, resulting in the removal of a lobe of his liver. A
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2. daptation to the reduced size of the liver leads to
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A) metaplasia
B) organ atrophy qw




C) compensatory hyperplasia qw




D) physiologic hypertrophy qw




A person eating peanuts starts choking and collapses. His airway obstruction is partiall
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y cleared, but he remains hypoxic until he reaches the hospital. The prolonged cell hypo
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3. xia caused a cerebral infarction and resulting
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A) caspase activation qw




B) coagulation necrosis qw




C) rapid phagocytosisqw




D) protein p53 deficiency qw qw




Bacteria and viruses cause cell damage by
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4. , which is unique from the intracellular qw qw qw qw qw qw



qw damage caused by other injurious agents.
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A) disrupting the sodium/potassium ATPase pump qw qw qw qw




B) interrupting oxidative metabolism processes qw qw qw




C) replicating and producing continued injury qw qw qw qw




D) decreasing protein synthesis and function qw qw qw qw




The patient has a prolonged interruption in arterial blood flow to his left kidney, causing hypo
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5. xic cell injury and the release of free radicals. Free radicals damage cells by:
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A) destroying phospholipids in the cell membrane. qw qw qw qw qw




B) altering the immune response of the cell.
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C) disrupting calcium storage in the cell. qw qw qw qw qw




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,D) inactivation of enzymes and mitochondria. qw qw qw qw




6. Injured cells have impaired flow of substances through the cell membrane as a result of:
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A) increased fat load. qw qw




B) altered permeability. qw




C) altered glucose utilization.
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D) increased surface receptors. qw qw




7. Reversible adaptive intracellular responses are initiated by:
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A) stimulus overload. qw




B) genetic mutations. qw




C) chemical messengers. qw




D) mitochondrial DNA. qw




8. Injured cells become very swollen as a result of:
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A) increased cell protein synthesis. qw qw qw




B) altered cell volume regulation.
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C) passive entry of potassium into the cell.
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D) bleb formation in the plasma membrane.
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A diabetic patient has impaired sensation, circulation, and oxygenation of his feet. He steps o
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n a piece of glass, the wound does not heal, and the area tissue becomes necrotic. The necro
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9. tic cell death is characterized by:
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A) rapid apoptosis. qw




B) cellular rupture. qw




C) shrinkage and collapse. qw qw




D) chronic inflammation. qw




A 99-year-
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10. old woman has experienced the decline of cell function associated with age. A group of the
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ories of cellular aging focus on programmed:
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A) changes with genetic influences. qw qw qw




B) elimination of cell receptor sites. qw qw qw qw




C) insufficient telomerase enzyme. qw qw




D) DNA mutation or faulty repair.
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An 89-year- qw



old female patient has experienced significant decreases in her mobility and stamina during
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a 3- qw



11. week hospital stay for the treatment of a femoral head fracture. Which of the following phe
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nomena most likely accounts for the patients decrease in muscle function
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that underlies her reduced mobility?
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,A) Impaired muscle cell metabolism resulting from metaplasia
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B) Dysplasia as a consequence of inflammation during bone remodeling
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C) Disuse atrophy of muscle cells during a prolonged period of immobility
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D) Ischemic atrophy resulting from vascular changes while on bedrest
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A 20-year-
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old college student has presented to her campus medical clinic for a scheduled Papanicolaou
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12. (Pap) smear. The clinician who will interpret the smear will examine cell samples for eviden
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ce of:qw




A) changes in cell shape, size, and organization. qw qw qw qw qw qw




B) the presence of unexpected cell types.
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C) ischemic changes in cell samples. qw qw qw qw




D) abnormally high numbers of cells in a specified field. qw qw qw qw qw qw qw qw




Which of the following pathophysiologic processes is most likely to result in metastatic calcifi
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13. tion?
A) Benign prostatic hyperplasia qw qw




B) Liver cirrhosis qw




C) Impaired glycogen metabolism qw qw




D) Hyperparathyroidism
Despite the low levels of radiation used in contemporary radiologic imaging, a radiology tech
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cian is aware of the need to minimize her exposure to ionizing radiation. What is the primary r
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14. ionale for the technicians precautions?
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A) Radiation stimulates pathologic cell hypertrophy and hyperplasia.
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B) Radiation results in the accumulation of endogenous waste products in the cytoplasm.
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C) Radiation interferes with DNA synthesis and mitosis.
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D) Radiation decreases the action potential of rapidly dividing cells.
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The parents of a 4-year-
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old girl have sought care because their daughter has admitted to chewing and swallowing im
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15. ported toy figurines that have been determined to be made of lead. Which of the following bl
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ood tests should the care team prioritize?
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A) White blood cell levels with differential qw qw qw qw qw




B) Red blood cell levels and morphology
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C) Urea and creatinine levelsqw qw qw




D) Liver function panel qw qw




A 70-year-
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old male patient has been admitted to a hospital for the treatment of a recent hemorrhagic stro
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16. e that has left him with numerous motor and sensory deficits. These deficits
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are most likely the result of which of the following mechanisms of cell injury?
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, A) Free radical injury qw qw




B) Hypoxia and ATP depletion qw qw qw




C) Interference with DNA synthesis qw qw qw




D) Impaired calcium homeostasis qw qw




Which of the following processes associated with cellular injury is most likely to be rever
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17. sible?
A) Cell damage resulting from accumulation of fat in the cytoplasm
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B) Cellular changes as a result of ionizing radiation
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C) Cell damage from accumulation of free radicals
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D) Apoptosis
18. The extrinsic pathway of apoptosis can be initiated by:
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A) damage to cellular DNA. qw qw qw




B) decreased ATP levels. qw qw




C) activation of the p53 protein. qw qw qw qw




D) activation of death receptors on the cell surface.
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A patient with severe peripheral vascular disease has developed signs of dry gangrene on the
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great toe of one foot. Which of the following pathophysiologic processes most likely contrib
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19. uted to this diagnosis?
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A) Inappropriate activation of apoptosis qw qw qw




B) Bacterial invasion qw




C) Impaired arterial blood supply qw qw qw




D) Metaplastic cellular changes qw qw




20. Which of the following facts underlies the concept of replicative senescence?
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Genes controlling longevity are present or absent in varying quantities among different in
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A) ividuals.
B) Telomeres become progressively shorter in successive generations of a cell.
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The damaging influence of free radicals increases exponentially in later generations of a
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C) cell.
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D) Aging produces mutations in DNA and deficits in DNA repair.
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Answer Key
1. A
2. C
3. B
4. C




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