HMX LATEST
PHARMACOLOGY
EXAM
A __ antagonist acts by competing for the same receptor with the
endogenous ligand. So that the receptor cannot be activated by the
endogenous ligand. Basal activity still ocurring. - ANSWERS-
competitive antagonist
A __ antagonist produces a comformational change in the receptor that
blocks that receptor being activated by the ligand. Basal activity still
occurs - ANSWERS-non-compeitive antagonist
An __ agonist prevents the ligand from binding the receptor and blocks
the activity of the receptor so that even basal activity cannot occur -
ANSWERS-inverse agonist
Insuline receptor belongs to ___ receptor superfamily - ANSWERS-
kinase-linked receptors
Enzymes are located __ the cell - ANSWERS-within
END OF
PAGE
1
, HMX LATEST
PHARMACOLOGY
EXAM
The second messenger ion channels are indirectly regulated by signaling
downstream of __ - ANSWERS-G protein coupled receptors
The voltage-gated ion channels are activated by changes in the __ near
the channel. Therefore they are not considerate receptors. - ANSWERS-
electrical membrane potential
Multiple myeloma is cancer of __ cells. When __ cells become
cancerous and grow out of control, this is called myeloma. -
ANSWERS-plasma;plasma
CAR T cell therapy is used as a treatment for multiple myeloma, an
immunotherapy involving administration of __ cells that have been
genetically engineered to target __cells - ANSWERS-T cells; cancer
cells
A response produced by a drug at a cellular protein. - ANSWERS-
molecular drug response
END OF
PAGE
2
, HMX LATEST
PHARMACOLOGY
EXAM
A response produced by a drug at the organismal level. - ANSWERS-
Physiological drug response
A decrease in body temperature produced by a drug is an example of a
__ drug response - ANSWERS-Physiological drug response
A decrease in enzyme activity produced by a drug is an example of __
drug response - ANSWERS-molecular
A downstream change in cellular function produced by a drug. -
ANSWERS-Cellular drug response
The strenght of the drug-receptor complex can be messured looking at
the __ of the drug for the receptor - ANSWERS-affinity
When the binding of a drug to a receptor reach __% saturation even if
the concentration of a drug is increased the number of receptors bound
will not increase - ANSWERS-100%
END OF
PAGE
3
, HMX LATEST
PHARMACOLOGY
EXAM
__ (Kd) is the concentration of the drug required to occupy 50% of the
receptors at equilibrium. - ANSWERS-equilibrium dissociation constant
A lower kd value means it has __ affinity for that receptor. A higher kd
value means the drug has __ affinity with that receptor. - ANSWERS-
higher; lower
Any other sites in the body the drug binds to other than its target are
referred to as ___. - ANSWERS-unintended sites
In general, a drug that has high selectivity for its intended site or
receptor has a __ Kd value, which means that it has __ affinity for that
receptor. - ANSWERS-low;high
__ is the maximal response of a drug. It is used to mesure drug efficacy -
ANSWERS-Emax.
A higher Emax value means that the drug has __ efficacy - ANSWERS-
higher
END OF
PAGE
4
PHARMACOLOGY
EXAM
A __ antagonist acts by competing for the same receptor with the
endogenous ligand. So that the receptor cannot be activated by the
endogenous ligand. Basal activity still ocurring. - ANSWERS-
competitive antagonist
A __ antagonist produces a comformational change in the receptor that
blocks that receptor being activated by the ligand. Basal activity still
occurs - ANSWERS-non-compeitive antagonist
An __ agonist prevents the ligand from binding the receptor and blocks
the activity of the receptor so that even basal activity cannot occur -
ANSWERS-inverse agonist
Insuline receptor belongs to ___ receptor superfamily - ANSWERS-
kinase-linked receptors
Enzymes are located __ the cell - ANSWERS-within
END OF
PAGE
1
, HMX LATEST
PHARMACOLOGY
EXAM
The second messenger ion channels are indirectly regulated by signaling
downstream of __ - ANSWERS-G protein coupled receptors
The voltage-gated ion channels are activated by changes in the __ near
the channel. Therefore they are not considerate receptors. - ANSWERS-
electrical membrane potential
Multiple myeloma is cancer of __ cells. When __ cells become
cancerous and grow out of control, this is called myeloma. -
ANSWERS-plasma;plasma
CAR T cell therapy is used as a treatment for multiple myeloma, an
immunotherapy involving administration of __ cells that have been
genetically engineered to target __cells - ANSWERS-T cells; cancer
cells
A response produced by a drug at a cellular protein. - ANSWERS-
molecular drug response
END OF
PAGE
2
, HMX LATEST
PHARMACOLOGY
EXAM
A response produced by a drug at the organismal level. - ANSWERS-
Physiological drug response
A decrease in body temperature produced by a drug is an example of a
__ drug response - ANSWERS-Physiological drug response
A decrease in enzyme activity produced by a drug is an example of __
drug response - ANSWERS-molecular
A downstream change in cellular function produced by a drug. -
ANSWERS-Cellular drug response
The strenght of the drug-receptor complex can be messured looking at
the __ of the drug for the receptor - ANSWERS-affinity
When the binding of a drug to a receptor reach __% saturation even if
the concentration of a drug is increased the number of receptors bound
will not increase - ANSWERS-100%
END OF
PAGE
3
, HMX LATEST
PHARMACOLOGY
EXAM
__ (Kd) is the concentration of the drug required to occupy 50% of the
receptors at equilibrium. - ANSWERS-equilibrium dissociation constant
A lower kd value means it has __ affinity for that receptor. A higher kd
value means the drug has __ affinity with that receptor. - ANSWERS-
higher; lower
Any other sites in the body the drug binds to other than its target are
referred to as ___. - ANSWERS-unintended sites
In general, a drug that has high selectivity for its intended site or
receptor has a __ Kd value, which means that it has __ affinity for that
receptor. - ANSWERS-low;high
__ is the maximal response of a drug. It is used to mesure drug efficacy -
ANSWERS-Emax.
A higher Emax value means that the drug has __ efficacy - ANSWERS-
higher
END OF
PAGE
4
