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COMPLETE 250 QUESTIONS AND ANSWERS WITH
CORRECT DETAILED RATIONALES| GRADED A+
advanced Pathophysiology(MARYVILLE
UNIVERSITY)
Which diseases are commonly associated with anemia of chronic disease? (Select all that apply.)
a. Rheumatoid arthritis
b. Acquired immunodeficiency syndrome (AIDS)
c. Polycythemia vera
d. Systemic lupus erythematosus
e. Chronic hepatitis –
ANS :*A, B, D, E
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*AIDS, rheumatoid arthritis, systemic lupus erythematosus, malaria, acute and chronic hepatitis, and chronic
renal failure are commonly associated with anemias of chronic disease.
Which type of anemia is characterized by fatigue, weakness, and dyspnea, as well as conjunctiva of the eyes
and brittle, concave nails?
a. Pernicious
b. Aplastic
c. Iron deficiency
d. Hemolytic –
ANS :*C
*Early symptoms of iron deficiency anemia (IDA) include fatigue, weakness, and shortness of breath. Pale
earlobes, palms, and conjunctivae (see Figure 28-4) are also common signs. Progressive IDA causes more
severe alterations, with structural and functional changes apparent in epithelial tissue (see Figure 28-4). The
nails become brittle, thin, coarsely ridged, and spoon-shaped or concave (koilonychia) as a result of impaired
capillary circulation. The tongue becomes red, sore, and painful.
Which statement concerning erythrocytes is true?
a. Erythrocytes contain a nucleus, mitochondria, and ribosomes.
b. Erythrocytes synthesize proteins.
c. Erythrocytes have the ability to change shape to squeeze through microcirculation.
d. Erythrocyte colony-stimulating factor (E-CSF) stimulates erythrocytes.
- ANS :*C
*Reversible deformity enables the erythrocyte to assume a more compact torpedo-like shape, squeeze
through the microcirculation, and return to normal.
Which blood cells are the chief phagocytes involved in the early inflammation process?
a. Neutrophils
b. Eosinophils
c. Monocytes
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d. Erythrocytes –
ANS :A
Which blood cells are biconcave in shape and have the capacity to be reversibly deformed?
a. Neutrophils
b. Eosinophils
c. Monocytes
d. Erythrocytes –
ANS :*D
*The erythrocyte's size and shape are ideally suited to its function as a gas carrier. A red blood cell (RBC) is a
small disk with two unique properties: (1) a biconcave shape and (2) the capacity to be reversibly deformed.
What is the life span of an erythrocyte (in days)?
a. 20 to 30
b. 100 to 120
c. 60 to 90
d. 200 to 240 –
ANS :*B
*Because it cannot undergo mitotic division, the erythrocyte has a limited life span of approximately 120 days.
Local signs and symptoms of Hodgkin disease-related lymphadenopathy are a result of which of the following?
a. Pressure and ischemia
b. Inflammation and ischemia
c. Pressure and obstruction
d. Inflammation and pressure –
ANS :*C
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*Local symptoms caused by pressure and obstruction of the lymph nodes are the result of lymphadenopathy.
Which statement best describes heparin-induced thrombocytopenia (HIT)?
a. Immunoglobulin G immune-mediated adverse drug reaction that reduces circulating platelets
b. Hematologic reaction to heparin in which the bone marrow is unable to produce sufficient platelets to meet
the body's needs
c. Immunoglobulin E-mediated allergic drug reaction that reduces circulating platelets
d. Cell-mediated drug reaction in which macrophages process the heparin and platelet complexes that are then
destroyed by activated cytotoxic T cells.
- ANS :*A
*Heparin is a common cause of drug-induced thrombocytopenia. HIT is an immune-mediated, adverse drug
reaction caused by immunoglobulin G antibodies that leads to increased platelet consumption and a decrease
in platelet counts.
Which disorder is described as an unregulated release of thrombin with subsequent fibrin formation and
accelerated fibrinolysis?
a. Disseminated intravascular coagulation (DIC)
b. Immune thrombocytopenic purpura (ITP)
c. Heparin-induced thrombocytopenia (HIT)
d. Essential thrombocythemia (ET) –
ANS :*D
*DIC is an acquired clinical syndrome characterized by widespread activation of coagulation resulting in the
formation of fibrin clots in medium and small vessels throughout the body.
In disseminated intravascular coagulation (DIC), what activates the coagulation cascade?
a. Cytokines, such as platelet-activating factor (PAF), and tumor necrosis factor- alpha (TNF-α).
b. Thromboxane A, causing platelets to aggregate and consume clotting factors.
c. Tissue factor (TF) located in the endothelial layer of blood vessels and subcutaneous tissue.
d. Endotoxins from gram-negative and gram-positive bacteria circulating in the bloodstream. - ANS :*C
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