NR507 MIDTERM EXAM
2023 / NR 507 WEEK 4
MIDTERM ADVANCED
PATHOPHYSIOLOGY
MIDTERM EXAM LATEST
CHAMBERLAIN COLLEGE OF
NURSING (VERSION A) WITH
100% CORRECT ANSWERS
2025
Hypersensitivity Type 1 correct answers >> Type 1:
Allergic Reaction
Mediated by IgE
Inflammation due to mast cell degranulation
local symptoms: Itching, rash
Systemic symptoms: wheezing
Most dangerous form: anaphylactic reaction-systemic
hypotension, severe bronchoconstriction
Main treatment: epinephrine
GRADED A+
,Hypersensitivity Type 2 correct answers >> Type 2:
Cytotoxic, tissue-specific (thyroid tissue)
Primary effector cells: Macrophages
Can cause tissue damage or alter the function
Example: Graves disease (alters thyroid function but does
not alter tissue)
Example: Incompatible blood type (cell/tissue damage)-
Severe transfusion reaction occurs and the transfused
erythrocytes are destroyed by agglutination or
complement-mediated lysis
Hypersensitivity Type 2 and 3 difference correct
answers >> Type 2: Organ-specific, the antibody binds
to an antigen on the cell surface
Type 3: Not organ-specific, the antibody binds to soluble
antigen outside the cell surface that was released into the
blood or body fluids and then the complex is distributed
into tissues
Hypersensitivity Type 3 Examples correct answers >>
Rheumatoid Arthritis: antigen/antibodies are deposited in
the joints
Systemic Lupus Erythematosus (SLE)- very closely related
to autoimmunity-antigen/antibodies deposit in organs
that cause tissue damage
GRADED A+
, Scope of damage of SLE- Type 3 Hypersensitivity-
autoimmune response correct answers >> rash
confined to cheeks (malar rash)
discoid rash (raised, patchy, scaly)
photosensitivity
oral/nasopharyngeal ulcers
hematologic disorders
immunologic disorders
non-erosive arthritis
serositis
renal disorder (proteinuria)
neurologic disorders (seizures)
antinuclear antibody (ANA)
Autoimmunity correct answers >> Familial
Affected family members may not have same dz, but
several members may have other disorders characterized
by a variety of hypersensitivity reactions that include
autoimmune or allergic reactions
Associations with particular autoimmune diseases have
been identified for a variety of major histocompatibility
complex (MHC) alleles or non-MHC genes
GRADED A+
2023 / NR 507 WEEK 4
MIDTERM ADVANCED
PATHOPHYSIOLOGY
MIDTERM EXAM LATEST
CHAMBERLAIN COLLEGE OF
NURSING (VERSION A) WITH
100% CORRECT ANSWERS
2025
Hypersensitivity Type 1 correct answers >> Type 1:
Allergic Reaction
Mediated by IgE
Inflammation due to mast cell degranulation
local symptoms: Itching, rash
Systemic symptoms: wheezing
Most dangerous form: anaphylactic reaction-systemic
hypotension, severe bronchoconstriction
Main treatment: epinephrine
GRADED A+
,Hypersensitivity Type 2 correct answers >> Type 2:
Cytotoxic, tissue-specific (thyroid tissue)
Primary effector cells: Macrophages
Can cause tissue damage or alter the function
Example: Graves disease (alters thyroid function but does
not alter tissue)
Example: Incompatible blood type (cell/tissue damage)-
Severe transfusion reaction occurs and the transfused
erythrocytes are destroyed by agglutination or
complement-mediated lysis
Hypersensitivity Type 2 and 3 difference correct
answers >> Type 2: Organ-specific, the antibody binds
to an antigen on the cell surface
Type 3: Not organ-specific, the antibody binds to soluble
antigen outside the cell surface that was released into the
blood or body fluids and then the complex is distributed
into tissues
Hypersensitivity Type 3 Examples correct answers >>
Rheumatoid Arthritis: antigen/antibodies are deposited in
the joints
Systemic Lupus Erythematosus (SLE)- very closely related
to autoimmunity-antigen/antibodies deposit in organs
that cause tissue damage
GRADED A+
, Scope of damage of SLE- Type 3 Hypersensitivity-
autoimmune response correct answers >> rash
confined to cheeks (malar rash)
discoid rash (raised, patchy, scaly)
photosensitivity
oral/nasopharyngeal ulcers
hematologic disorders
immunologic disorders
non-erosive arthritis
serositis
renal disorder (proteinuria)
neurologic disorders (seizures)
antinuclear antibody (ANA)
Autoimmunity correct answers >> Familial
Affected family members may not have same dz, but
several members may have other disorders characterized
by a variety of hypersensitivity reactions that include
autoimmune or allergic reactions
Associations with particular autoimmune diseases have
been identified for a variety of major histocompatibility
complex (MHC) alleles or non-MHC genes
GRADED A+
