Veterinary Pharmacology Final Exam

Veterinary Pharmacology Final Exam
Questions And Answers


Phospholipase n- nAnswer n- nPhospholipids nare nmade ninto narachidonic nacid nby nwhat nenzymes?

Cyclooxygenase n- nAnswer n- nArachidonic nacid nis nmade ninto nPGG2 nby nwhat nenzyme?

Anti-inflammatory, nanalgesic nand nantipyretic n- nAnswer n- nWhat nare nthe n3 npharmacological neffects nof
nNSAIDs?



Anti-inflammatory n- nAnswer n- nWhat npharmacological neffects nof nNSAIDs?

- nmodifications nof ninflammatory nreactions

- ndecrease nin ninflammatory nprostaglandin nproduction

Analgesic n- nAnswer n- nWhat npharmacological neffects nof nNSAIDs?

- nreduction nof npain

Antipyretic n- nAnswer n- nWhat npharmacological neffects nof nNSAIDs?

- nlowering nof nraised ntemperature

- npartly ndue nto ndecreased nrelease nof nprostaglandins nin nresponse nto ninterleukin-1 n(IL-1)

TXA2 n- nAnswer n- nThe nantithrombotic neffect nis na nside neffect nof nNSAIDs nbecause nthey ninhibit n____
nsynthesis



False n(causes nstomach nulcers nand ninternal nbleeding) n- nAnswer n- nTrue/False

Concurrent nuse nof ncorticosteroids nand nNSAIDs nshould nbe navoided ndue nto nincreased nrisk nof nrenal
nfailure?



COX2 n- nAnswer n- nWhich nCOX nis nthe ninducible nform? nAlso nit nsynthesizes nprostaglandins nresponsible nfor
ninflammation nand npain



COX1 n- nAnswer n- nWhich nCOX nis nthe nbasal nform? nAlso nit nsynthesizes nprostaglandins nfor nmaintenance
nand nprotection nof nthe nGI ntract



Aspirin n- nAnswer n- n____ nanti-inflammatory nMechanism, npermanently ninactivates nprostaglandin
nsynthase nuntil nit nis nreplaced nby nnew nsynthesis, ngranulocytes n(neutrophils, neosinophils, nmast ncells, nand

nbasophils) nalso neffected



Rimadyl n(Carprofen) n- nAnswer n- n- nWorld's nmost nfrequently nprescribed ncanine nNSAID

- nIndicated nfor nthe nrelief nof npain nand ninflammation nassociated nwith nosteoarthritis nin ndogs

,- nReceived napproval nfor ncontrolling npost noperative npain nassociated nwith nsoft ntissue nand northopedic
nsurgery nin ndogs



- nLower nincidence nof nGI ndisturbance

False n(NEVER) n- nAnswer n- nTrue/False

You ncan nsometimes nadminister ncats nCarprofen n(Rimadyl) nfor nOA

injectable n- nAnswer n- nThe n____ nform nof nRimadyl nis nindicated nfor nthe ncontrol nof npain nand ninflammation
nassociated nwith nosteoarthritis nand nboth nsoft ntissue nand northopedic nsurgeries



phenobarbital n- nAnswer n- nConcurrent nuse nof ncarprofen nand n____ ncan nalter nthe nactivity nof none nor nboth
ndrugs



Zubrin n(Tepoxalin) n- nAnswer n- n___ nmechanism nof naction nis ninhibition nof ncyclooxygenase nactivity nand
nlipoxygenase nand nis nthus nclassified nas na ndual ninhibitor nof narachidonic nacid nmetabolism



True n- nAnswer n- nTrue/False

Zubrin nis nnot napproved nin ncats

leukotrienes n- nAnswer n- nBy nusing nZubrin nin ndogs nyou nare ninhibiting nlipoxygenase nwhich nis nused nto
nproduced ninflammatory n_____



Previcox n(firocoxib) n- nAnswer n- n- nApproved nto ntreat npain nand ninflammation nin ndogs nsuffering nfrom
nosteoarthritis nand nreported nto nhave n24-hour ntherapeutic npain nrelief



- nselectively ninhibit nCOX-2 ncyclooxygenase nactivity

False n- nAnswer n- nTrue/False

Previcox nis nindicated nfor nuse nin ncats

Anorexia n- nAnswer n- nWhat nis nthe ncommon ninitial nsign nin nanimals nwho nhave na nrisk nof nhepatotoxicity
nwhen non nan nNSAID



ALT n- nAnswer n- n3-4 nfold nincreases nin n___ n(a nlab ntest) nabove nnormal nrange nmay nbe nan nindication nof
nacute nhepatopathy nwhen na ndog nis non nan nNSAID



Cosequin n(glucosamine nand nchondroitin nsulfate) n- nAnswer n- nis nmarketed nas na nveterinary nnutraceutical,
nand nclaims nto nstimulate nthe nsynthesis nof nsynovial nfluid nand ninhibits ndegradation nof nthe narticular

ncartilage



Adequan n- nAnswer n- n- nis nan nFDA-approved nglycosaminoglycan npolysulfate nester nand nis ncommonly
ncalled nP-GAGS



- none nclinical nstudy nof ndogs nwith nhip ndysplasia nfound ngreatest nimprovement nin northopedic nscores nat
ndosages nof n4.4 nmg/kg, nIM nevery n3-5 ndays nfor n8 ninjections



broad n- nAnswer n- n____ nspectrum nantibacterials nare nactive nagainst nboth nGram-positive nand nGram-
negative norganisms. n

, - nExamples ninclude: ntetracyclines, nphenicols, nfluoroquinolones, n"third-generation" nand n"fourth-
generation" ncephalosporins.

narrow n- nAnswer n- n____ nspectrum nantibacterials nhave nlimited nactivity nand nare nprimarily nonly nuseful
nagainst nparticular nspecies nof nmicroorganisms. n



- nFor nexample, nglycopeptides nand nbacitracin nare nonly neffective nagainst nGram-positive nbacteria,
nwhereas npolymixins nare nusually nonly neffective nagainst nGram nnegative nbacteria. nAminoglycosides nand

nsulfonamides nare nonly neffective nagainst naerobic norganisms, nwhile nnitroimidazoles nare ngenerally nonly

neffective nfor nanaerobes.



Positive n- nAnswer n- nGram n___ nbacteria



- nStreptococcus nspp.

- nStaphylococcus nspp.

- nClostridium nperfringens

- nCorynebacterium

Negative n- nAnswer n- nGram n___ nbacteria

Escherichia ncoli

Proteus nspp.

Pseudomonas nspp.

Salmonella nspp.

Brucella

Vibrio

Pasterurella nspp.

Penicillins nand ncephalosporins n- nAnswer n- nInhibition nof nCell nWall nSynthesis n(bactericidal)

Polymixin nB n- nAnswer n- nAlter ncell nmembrane npermeability n(bactericidal)

Aminoglycosides, nTetracyclines, nFlorfenicol, nmacrolides nand nlincomycin n- nAnswer n- nInhibition nof
nprotein nsynthesis n(Bactericidal nor nBacteriostatic) n---- n[what n5 ndrug nclasses]



Sulfonamides n- nAnswer n- nInterfere nwith nmetabolism n(bacteriostatic)

Quinolones n- nAnswer n- nNucleic nacid nimpairment n(bactericidal)

Beta-lactams n- nAnswer n- nWhat nClass nof nCell nWall nAgents?

- nIncludes nPenicillins nand nCephalosporins

- nBind nto nPenicllin-binding nproteins n(PBP's)