HESI PHARMACOLOGY EVOLVE ACTUAL EXAM QUESTIONS AND ANSWERS WITH
EXPERTS FEEDBACK 2025-2026|WELL STRUCTURED|100% PASS
QUESTIONS ANSWERS
A client who has been taking phenazopy- C) Have you had any relief from urinary
ridine (Pyridium) for symptoms of urethri-pain, burning, or urgency?
tis and cystitis comes to the clinic be- Feedback:
cause her urine is reddish-orange.Which Phenazopyridine, an over-the-counter
question should the practical nurse ask urinary analgesic, acts on the mucosa of
to determine if the medication has been the urinary tract to relieve urinary pain,
effective? burning, itching, or urgency (C) associ-
A) How much water have you been drink- ated with urethritis and cystitis. Although
ing each day? determining if the client is forcing fluids
B) Does the urine color stain your toilet (A), experiencing staining from Pyridi-
bowl or undergarments? um's side effect (B), or having signs of
C) Have you had any relief from urinary a urinary infection (D) are worthwhile as-
pain, burning, or urgency? sessments, the therapeutic response of
D) Did your urine appear cloudy or have Pyridium is related to urinary discomforts
a foul odor on voiding? only.
D) Shave with an electric razor.
A male client who has been receiv- Feedback:
ing an antineoplastic drug has devel- Thrombocytopenia is a common side ef-
oped thrombocytopenia. What instruc- fect of bone marrow depression caused
tions should the practical nurse (PN) re- by several antineoplastic agents. The
inforce? client is experiencing a low platelet count
A) Use suppository form of drugs. and should use an electric razor (D) to
B) Avoid large public gatherings. reduce his risk of bleeding. (A, B, and C)
C) Rise slowly when standing up. are not indicated for a client who needs
D) Shave with an electric razor. to implement thrombocytopenia precau-
tions.
The practical nurse (PN) is caring for a B) Weight gain.
client who has been taking prednisone Feedback:
(Deltasone) daily for a year. Which ad- Long term use of prednisone causes flu-
verse effect should the PN document in id retention and redistribution of fat de-
the client's record? position. Weight gain (B) and moon face
A) Photosensitvity. reflect adverse effects of long-term pred-
B) Weight gain. nisone use and should be documented.
C) Loss of hair. (A, C, and D) do not occur with treatment
D) Pale skin color. using prednisone.
A female client with recurring headaches
B) Hepatic enzymes.
tells the practical nurse (PN) that she has
Feedback:
been taking at least 4 grams of aceta-
, HESI PHARMACOLOGY EVOLVE ACTUAL EXAM QUESTIONS AND ANSWERS WITH
EXPERTS FEEDBACK 2025-2026|WELL STRUCTURED|100% PASS
QUESTIONS ANSWERS
minophen a day. Which laboratory stud- Liver toxicity can occur when doses of
ies should the PN review for this client? acetaminophen exceed 4 grams a day,
A) Creatinine clearance. resulting in an elevation in hepatic en-
B) Hepatic enzymes. zyme values (B). (A, C, and D) do not
C) Coagulation values. reveal findings related to acetaminophen
D) Arterial blood gases. toxicity.
A client receives a prescription for an oral
opioid analgesic for post-operative pain. A) Constipation.
Which adverse effect should the practi- Feedback:
cal nurse (PN) monitor for with the client? Opioid analgesics slow peristalsis, which
A) Constipation. leads to constipation (A), a common side
B) Photosensitivity. effect of opiates. (B, C, and D) are not
C) Decreased heart rate. associated with opioid analgesics.
D) Frequent urination.
D) Place the medication between the up-
Which action should the practical nurse per molar teeth and cheek.
implement when administering a buccal Feedback:
medication? Buccal medications are placed between
A) Encourage the client to swallow. the upper molar teeth and the cheek
B) Administer water with medication. (D) for absorption by the capillaries of
C) Ensure the medication is positioned the oral mucosa. The client should be
under the tongue. cautioned against swallowing, not (A).
D) Place the medication between the up- Buccal medications are not administered
per molar teeth and cheek. with water (B). (C) describes sublingual
administration.
C) Understanding of diet modification.
Feedback:
To prevent a potentially lethal hyperten-
What assessment is most important for sive crisis, a tyramine-free diet should be
the practical nurse (PN) to obtain pri- maintained during antidepressant ther-
or to initiating medication therapy with apy with Nardil, a monoamine oxidase
phenelzine (Nardil) for a client with de- inhibitor (MAOI). It is most important to
pression? determine if the client understands diet
A) Activity level. modification (C) before Nardil is initiat-
B) Mood and affect. ed to prevent consumption of foods that
interact with Nardil. Although a client's
activity level (A) and mood and affect (B)
should be monitored during antidepres-
, HESI PHARMACOLOGY EVOLVE ACTUAL EXAM QUESTIONS AND ANSWERS WITH
EXPERTS FEEDBACK 2025-2026|WELL STRUCTURED|100% PASS
QUESTIONS ANSWERS
sant therapy, it is most important that the
client understand diet modifications. The
client's support system (D) and network
C) Understanding of diet modification.
of family and friends is important, but the
D) The client's support system.
client should understand the responsibil-
ity of dietary compliance with the med-
ication regimen.
The practical nurse (PN) is unable to
arouse a client who is receiving meperi-
A) Naloxone (Narcan).
dine (Demerol) for postoperative pain.
Feedback:
The client is stuporous, has constrict-
Narcan (A) is an opioid antagonist and
ed pupils, and a respiratory rate of 8
should be administered to reverse the ef-
breaths/minute. Which PRN prescription
fects of a Demerol, an opioid, overdose.
should the PN give the client?
(B, C, and D) are common postoperative
A) Naloxone (Narcan).
PRN prescriptions but are not indicated
B) Promethazine (Phenergan).
for narcotic overdose.
C) Metoclopramide (Reglan).
D) Bethanechol (Urecholine).
On which therapeutic action should the C) Decreased rate of contraction.
practical nurse (PN) base an explanation Feedback:
to a client who is receiving a cardiac Cardiac glycosides increase the force
glycoside? of cardiac contraction (inotropy) and de-
A) Decreased cardiac output. crease the heart rate (chronotropy) (C)
B) Increased renal perfusion. by decreasing the speed of conduction
C) Decreased rate of contraction. through the heart (dromotropy). (A, B,
D) Increased blood volume. and D) are incorrect.
A client with type 1 diabetes mellitus re-
ceived an early AM dose of regular in-
sulin per sliding scale. At 10:00 AM, the C) Irritability and confusion.
practical nurse (PN) should report which Feedback:
signs indicative of hypoglycemia? Irritability and confusion (C) are early
A) Urticaria and rash. signs of hypoglycemia. (A, B, and D) are
B) Nausea and diarrhea. not signs of hypoglycemia.
C) Irritability and confusion.
D) Fruity, acetone odor to the breath.
Which prescription should the practical
B) Epinephrine (Adrenalin).
nurse (PN) administer for a client who is
Feedback:
experiencing an anaphylactic reaction to
EXPERTS FEEDBACK 2025-2026|WELL STRUCTURED|100% PASS
QUESTIONS ANSWERS
A client who has been taking phenazopy- C) Have you had any relief from urinary
ridine (Pyridium) for symptoms of urethri-pain, burning, or urgency?
tis and cystitis comes to the clinic be- Feedback:
cause her urine is reddish-orange.Which Phenazopyridine, an over-the-counter
question should the practical nurse ask urinary analgesic, acts on the mucosa of
to determine if the medication has been the urinary tract to relieve urinary pain,
effective? burning, itching, or urgency (C) associ-
A) How much water have you been drink- ated with urethritis and cystitis. Although
ing each day? determining if the client is forcing fluids
B) Does the urine color stain your toilet (A), experiencing staining from Pyridi-
bowl or undergarments? um's side effect (B), or having signs of
C) Have you had any relief from urinary a urinary infection (D) are worthwhile as-
pain, burning, or urgency? sessments, the therapeutic response of
D) Did your urine appear cloudy or have Pyridium is related to urinary discomforts
a foul odor on voiding? only.
D) Shave with an electric razor.
A male client who has been receiv- Feedback:
ing an antineoplastic drug has devel- Thrombocytopenia is a common side ef-
oped thrombocytopenia. What instruc- fect of bone marrow depression caused
tions should the practical nurse (PN) re- by several antineoplastic agents. The
inforce? client is experiencing a low platelet count
A) Use suppository form of drugs. and should use an electric razor (D) to
B) Avoid large public gatherings. reduce his risk of bleeding. (A, B, and C)
C) Rise slowly when standing up. are not indicated for a client who needs
D) Shave with an electric razor. to implement thrombocytopenia precau-
tions.
The practical nurse (PN) is caring for a B) Weight gain.
client who has been taking prednisone Feedback:
(Deltasone) daily for a year. Which ad- Long term use of prednisone causes flu-
verse effect should the PN document in id retention and redistribution of fat de-
the client's record? position. Weight gain (B) and moon face
A) Photosensitvity. reflect adverse effects of long-term pred-
B) Weight gain. nisone use and should be documented.
C) Loss of hair. (A, C, and D) do not occur with treatment
D) Pale skin color. using prednisone.
A female client with recurring headaches
B) Hepatic enzymes.
tells the practical nurse (PN) that she has
Feedback:
been taking at least 4 grams of aceta-
, HESI PHARMACOLOGY EVOLVE ACTUAL EXAM QUESTIONS AND ANSWERS WITH
EXPERTS FEEDBACK 2025-2026|WELL STRUCTURED|100% PASS
QUESTIONS ANSWERS
minophen a day. Which laboratory stud- Liver toxicity can occur when doses of
ies should the PN review for this client? acetaminophen exceed 4 grams a day,
A) Creatinine clearance. resulting in an elevation in hepatic en-
B) Hepatic enzymes. zyme values (B). (A, C, and D) do not
C) Coagulation values. reveal findings related to acetaminophen
D) Arterial blood gases. toxicity.
A client receives a prescription for an oral
opioid analgesic for post-operative pain. A) Constipation.
Which adverse effect should the practi- Feedback:
cal nurse (PN) monitor for with the client? Opioid analgesics slow peristalsis, which
A) Constipation. leads to constipation (A), a common side
B) Photosensitivity. effect of opiates. (B, C, and D) are not
C) Decreased heart rate. associated with opioid analgesics.
D) Frequent urination.
D) Place the medication between the up-
Which action should the practical nurse per molar teeth and cheek.
implement when administering a buccal Feedback:
medication? Buccal medications are placed between
A) Encourage the client to swallow. the upper molar teeth and the cheek
B) Administer water with medication. (D) for absorption by the capillaries of
C) Ensure the medication is positioned the oral mucosa. The client should be
under the tongue. cautioned against swallowing, not (A).
D) Place the medication between the up- Buccal medications are not administered
per molar teeth and cheek. with water (B). (C) describes sublingual
administration.
C) Understanding of diet modification.
Feedback:
To prevent a potentially lethal hyperten-
What assessment is most important for sive crisis, a tyramine-free diet should be
the practical nurse (PN) to obtain pri- maintained during antidepressant ther-
or to initiating medication therapy with apy with Nardil, a monoamine oxidase
phenelzine (Nardil) for a client with de- inhibitor (MAOI). It is most important to
pression? determine if the client understands diet
A) Activity level. modification (C) before Nardil is initiat-
B) Mood and affect. ed to prevent consumption of foods that
interact with Nardil. Although a client's
activity level (A) and mood and affect (B)
should be monitored during antidepres-
, HESI PHARMACOLOGY EVOLVE ACTUAL EXAM QUESTIONS AND ANSWERS WITH
EXPERTS FEEDBACK 2025-2026|WELL STRUCTURED|100% PASS
QUESTIONS ANSWERS
sant therapy, it is most important that the
client understand diet modifications. The
client's support system (D) and network
C) Understanding of diet modification.
of family and friends is important, but the
D) The client's support system.
client should understand the responsibil-
ity of dietary compliance with the med-
ication regimen.
The practical nurse (PN) is unable to
arouse a client who is receiving meperi-
A) Naloxone (Narcan).
dine (Demerol) for postoperative pain.
Feedback:
The client is stuporous, has constrict-
Narcan (A) is an opioid antagonist and
ed pupils, and a respiratory rate of 8
should be administered to reverse the ef-
breaths/minute. Which PRN prescription
fects of a Demerol, an opioid, overdose.
should the PN give the client?
(B, C, and D) are common postoperative
A) Naloxone (Narcan).
PRN prescriptions but are not indicated
B) Promethazine (Phenergan).
for narcotic overdose.
C) Metoclopramide (Reglan).
D) Bethanechol (Urecholine).
On which therapeutic action should the C) Decreased rate of contraction.
practical nurse (PN) base an explanation Feedback:
to a client who is receiving a cardiac Cardiac glycosides increase the force
glycoside? of cardiac contraction (inotropy) and de-
A) Decreased cardiac output. crease the heart rate (chronotropy) (C)
B) Increased renal perfusion. by decreasing the speed of conduction
C) Decreased rate of contraction. through the heart (dromotropy). (A, B,
D) Increased blood volume. and D) are incorrect.
A client with type 1 diabetes mellitus re-
ceived an early AM dose of regular in-
sulin per sliding scale. At 10:00 AM, the C) Irritability and confusion.
practical nurse (PN) should report which Feedback:
signs indicative of hypoglycemia? Irritability and confusion (C) are early
A) Urticaria and rash. signs of hypoglycemia. (A, B, and D) are
B) Nausea and diarrhea. not signs of hypoglycemia.
C) Irritability and confusion.
D) Fruity, acetone odor to the breath.
Which prescription should the practical
B) Epinephrine (Adrenalin).
nurse (PN) administer for a client who is
Feedback:
experiencing an anaphylactic reaction to
