MLS HEMATOLOGY EXAM /HEMATOLOGY MLS ACTUAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
What is the first type of cell produced by the developing embryo? -(ANSWER)Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is fat? -(ANSWER)50%
Which of the following is not characteristic of pluripotent hematopoietic stem cells? -(ANSWER)Express
the stem marker CD13
In an adult, what are the two best areas for obtaining active bone marrow by aspiration? -
(ANSWER)Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone marrow (M:E ratio)? -(ANSWER)4:1
Which of the following does not accurately describe hematopoietic growth factors? -(ANSWER)Action of
majority is lineage restricted
In the third month of gestation, what is the primary site of hematopoiesis? -(ANSWER)Liver
The mechanism that relays information about tissue oxygen levels to erythropoietin-producing sites is
located in the: -(ANSWER)Kidney
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue located in the: -
(ANSWER)Thymus and bone marrow
Programmed cell death is called: -(ANSWER)Apoptosis
,MLS HEMATOLOGY EXAM /HEMATOLOGY MLS ACTUAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
In what area of the bone marrow does hematopoiesis take place? -(ANSWER)Cords
Bone marrow cellularity refers to the ration of: -(ANSWER)Hematopoietic tissue to adipose tissue
Interleukins and colony stimulating factors are cytokines produced by: -(ANSWER)Monocytes and T
lymphocytes
What is the approximate total blood volume in an adult? -(ANSWER)6 L
The myeloid progenitor cell can produce cells committed to: -(ANSWER)Granulocytic, erythrocytic,
monocytic, or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are: -(ANSWER)Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is considered abnormal? -(ANSWER)The
presence of 10% myeloblasts on the cell differential count
As most blood cell lines mature, which of the following is characteristic? -(ANSWER)Nucleus to
cytoplasm ratio (N:C) decreases
Which of the following describes thrombopoietin (TPO)? -(ANSWER)Hormone produced by the liver that
stimulates megakaryopoiesis
,MLS HEMATOLOGY EXAM /HEMATOLOGY MLS ACTUAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
When the hepatic phase of fetal life is reactivated in an adult, hematopoiesis can be termed: -
(ANSWER)Myeloid metaplasia or extramedullary
What is the average life span of a normal red blood cell? -(ANSWER)120 days
The Na+-K+ cation pump is an important mechanism in keeping the red blood cell intact. Its function is
to maintain a high level of: -(ANSWER)Intracellular K+
Which of the following depicts the structure of the hemoglobin molecule? -(ANSWER)Four heme groups,
four globin chains
Which of the following describes the process known as culling? -(ANSWER)Removal of abnormal red
cells by spleen
Hemoglobin forms that are incapable of oxygen transport include: -(ANSWER)Carboxyhemoglobin and
methemoglobin
The majority of iron found in an adult is a constituent of: -(ANSWER)Hemoglobin
A senescent red blood cell is one that has: -(ANSWER)Lived its life span
What red cell morphologic abnormality is described by the term "poikilocytosis"? -(ANSWER)Deviations
from normal shape
Howell-Jolly bodies are composed of: -(ANSWER)DNA
, MLS HEMATOLOGY EXAM /HEMATOLOGY MLS ACTUAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
When spherocytes are reported, what is observed on the peripheral blood smear? -(ANSWER)Red cells
without a central pallor
The red cells found in lead poisoning characteristically exhibit coarse granules composed of __________
that are reported as _________. -(ANSWER)Aggregated ribosomes; basophilic stippling
Rouleaux of red blood cells when seen in the monolayer of a blood smear is characteristic of: -
(ANSWER)Multiple myeloma
Which of the following is most frequently associated with the inclusion bodies seen in Color Plate 1? -
(ANSWER)Post-splenectomy
Which of the following statements about iron absorption is true? -(ANSWER)Absorption increases when
erythropoietic activity increases
What term describes a mature red blood cell that contains iron granules or deposits? -
(ANSWER)Siderocyte
Which of the following is associated with a "shift to the left" in the oxygen dissociation curve of
hemoglobin? -(ANSWER)Decreased oxygen release
Which of the following statements does not characterize erythropoietin (EPO)? -(ANSWER)Decreases
stimulation of erythropoiesis when cellular hypoxia increases
CORRECT DETAILED ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
What is the first type of cell produced by the developing embryo? -(ANSWER)Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is fat? -(ANSWER)50%
Which of the following is not characteristic of pluripotent hematopoietic stem cells? -(ANSWER)Express
the stem marker CD13
In an adult, what are the two best areas for obtaining active bone marrow by aspiration? -
(ANSWER)Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone marrow (M:E ratio)? -(ANSWER)4:1
Which of the following does not accurately describe hematopoietic growth factors? -(ANSWER)Action of
majority is lineage restricted
In the third month of gestation, what is the primary site of hematopoiesis? -(ANSWER)Liver
The mechanism that relays information about tissue oxygen levels to erythropoietin-producing sites is
located in the: -(ANSWER)Kidney
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue located in the: -
(ANSWER)Thymus and bone marrow
Programmed cell death is called: -(ANSWER)Apoptosis
,MLS HEMATOLOGY EXAM /HEMATOLOGY MLS ACTUAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
In what area of the bone marrow does hematopoiesis take place? -(ANSWER)Cords
Bone marrow cellularity refers to the ration of: -(ANSWER)Hematopoietic tissue to adipose tissue
Interleukins and colony stimulating factors are cytokines produced by: -(ANSWER)Monocytes and T
lymphocytes
What is the approximate total blood volume in an adult? -(ANSWER)6 L
The myeloid progenitor cell can produce cells committed to: -(ANSWER)Granulocytic, erythrocytic,
monocytic, or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are: -(ANSWER)Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is considered abnormal? -(ANSWER)The
presence of 10% myeloblasts on the cell differential count
As most blood cell lines mature, which of the following is characteristic? -(ANSWER)Nucleus to
cytoplasm ratio (N:C) decreases
Which of the following describes thrombopoietin (TPO)? -(ANSWER)Hormone produced by the liver that
stimulates megakaryopoiesis
,MLS HEMATOLOGY EXAM /HEMATOLOGY MLS ACTUAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
When the hepatic phase of fetal life is reactivated in an adult, hematopoiesis can be termed: -
(ANSWER)Myeloid metaplasia or extramedullary
What is the average life span of a normal red blood cell? -(ANSWER)120 days
The Na+-K+ cation pump is an important mechanism in keeping the red blood cell intact. Its function is
to maintain a high level of: -(ANSWER)Intracellular K+
Which of the following depicts the structure of the hemoglobin molecule? -(ANSWER)Four heme groups,
four globin chains
Which of the following describes the process known as culling? -(ANSWER)Removal of abnormal red
cells by spleen
Hemoglobin forms that are incapable of oxygen transport include: -(ANSWER)Carboxyhemoglobin and
methemoglobin
The majority of iron found in an adult is a constituent of: -(ANSWER)Hemoglobin
A senescent red blood cell is one that has: -(ANSWER)Lived its life span
What red cell morphologic abnormality is described by the term "poikilocytosis"? -(ANSWER)Deviations
from normal shape
Howell-Jolly bodies are composed of: -(ANSWER)DNA
, MLS HEMATOLOGY EXAM /HEMATOLOGY MLS ACTUAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
When spherocytes are reported, what is observed on the peripheral blood smear? -(ANSWER)Red cells
without a central pallor
The red cells found in lead poisoning characteristically exhibit coarse granules composed of __________
that are reported as _________. -(ANSWER)Aggregated ribosomes; basophilic stippling
Rouleaux of red blood cells when seen in the monolayer of a blood smear is characteristic of: -
(ANSWER)Multiple myeloma
Which of the following is most frequently associated with the inclusion bodies seen in Color Plate 1? -
(ANSWER)Post-splenectomy
Which of the following statements about iron absorption is true? -(ANSWER)Absorption increases when
erythropoietic activity increases
What term describes a mature red blood cell that contains iron granules or deposits? -
(ANSWER)Siderocyte
Which of the following is associated with a "shift to the left" in the oxygen dissociation curve of
hemoglobin? -(ANSWER)Decreased oxygen release
Which of the following statements does not characterize erythropoietin (EPO)? -(ANSWER)Decreases
stimulation of erythropoiesis when cellular hypoxia increases
