Questions and Answers 100% Pass
Pyrimidine dimers formed in DNA due to UV radiation can be repaired
by?
SOS repair
Double strand break repair
Mismatch repair
Photoreactivation repair (nucleotide excision repair)
Base excision repair - ✔✔Photoreactivation repair (nucleotide excision
repair)
Which of the following repair mechanisms uses methyl groups to
distinguish between parental and daughter strands?
1
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,Answers:
Mismatch repair
Photoreactivation repair (Nucleotide excision repair)
SOS repair
Double strand break repair
Base excision repair - ✔✔Mismatch repair
Which of the following types of molecules is always found in virions?
Answers:
Protein
RNA
Lipid
DNA
Carbohydrate - ✔✔Protein
2
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,A Barr body found within the female mammalian cell's nucleus is an
example of ___
Answers:
Euchromatin
Polytene chromosome
Pseudogenes
Heterochromatin
Cistron - ✔✔Heterochromatin
In vertebrate genes, transcription regulatory regions that contain CpG
islands are inactivated by which CpG modification?
Answers:
Methylation
Ubiquitination
Acetylation
Phosphorylation
3
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, Myristoylation - ✔✔Methylation
TATA-binding protein (TBP) is a key transcription factor in eukaryotes. A
schematic representation of the 240-amino acid TBP of yeast is shown in
Fig. 1 below, with the positions of 2 mutations indicated. The boxed area
represents the evolutionarily conserved C-terminal domain of TBP, and the
shaded (dark) regions of this domain represent two repeated elements
involved in DNA binding. One mutation (P65S) changes proline 65 to
serine and the other I143N changes isoleucine 143 to asparagine. Fig. 2
below represents autoradiographs of gels containing RNA transcripts
produced in extracts of wild type or mutant cells. Lanes 1-2 are from wild-
type yeast (WT), lanes 3-4 are from the I143N mutant and lanes 5-6 are
from P65S mutant, as indicated. Fig. 2A shows transcripts of a gene
transcribed by RNA polymerase I (Pol I). Fig. 2B shows transcripts of a
gene transcribed by RNA polymerase II (Pol II). Fig. 2C shows transcripts -
✔✔Whether mutant transcription phenotypes are due to perturbation of
TBP function.
4
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