PHARMACOLOGY 9TH EDITION BY
AMY KARCH CHAPTER 1-59 EXAM
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,Test Bank - Focus on Nursing Pharmacology (9th Edition by Karch) 3
Chapter 01 - Introduction to Drugs
What is the nurse's responsibility in pharmacology? (5 steps)
1. administer the drug
2. assess drug effects
3. intervening where needed to make more tolerable
4.providing patient teachings about drugs and the drug regimen
5.monitoring the overall patient care plan to prevent med errors
examples of inorganic compounds used as drugs
aluminum, fluoride, iron, and gold
preclinical trials
Chemicals tested on laboratory animals
phase 1 study
a pilot study of a potential drug using a small number of selected, usually healthy human volunteers
phase 2 study
drugs tested on informed patients with the disease
phase 3 study
Drug used in vast clinical market
phase IV study
continuous evaluation of a drug after it has been released for marketing
in order to be marketed, drugs must be evaluated and approved by the _?
FDA
generic drug
usually named for its chemical structure and is not protected by a brand name or trademark
brand-name drug
Pharmacodynamics
Key word: CHANGE
-the study of the interactions between the chemical components of living organisms (patients) and foreign
chemicals (drugs) being entered into the body
-"how does it change the patients chemistry/body ?"
-method of action
What are the four drug actions?
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,Test Bank - Focus on Nursing Pharmacology (9th Edition by Karch) 4
-replace or act as a substitute for missing chemicals
-increase or stimulate certain cellular activities
- depress or slow cellular activities
- interfere with the functioning of foreign cells
Agonist receptor
binds to a receptor site, stimulates a response (ex- epinephrine stimulates heart rate)
Antagonist receptor
substances or drugs that attach to receptors and prevent them from being activated
competitive antagonist
Drug competes with the agonist for binding to the receptor. If it binds, there is no response.
Non-competitive antagonist
Binds to a site different from the agonist changing the receptor site; not allowing the agonist to bind
Pharmacokinetics
the study of drug movement throughout the body
absorption
distribution
metabolism
excretion
a drug with a registered name or trademark given to a drug by a pharmaceutical company
what occurred in 1938?
Federal Food Drug and cosmetic act
Federal Food, Drug, and Cosmetic Act of 1938
Mandated tests for drug toxicity and provided means for recall of drugs; established procedures for
introducing new drugs; gave FDA the power of enforcement
Controlled Substances Act of 1970
Control over the coding of drugs and the enforcement of these codes to the FDA and the Drug Enforcement
Agency (DEA)
Orphan Drug Act of 1983
Provided incentives for the development of orphan drugs for treatment of rare diseases
Orphan drugs
Drugs that have been discovered, but are not financially viable and therefore have not been "adopted" by
any drug company
Generic name vs Brand/trade name vs chemical name
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, Test Bank - Focus on Nursing Pharmacology (9th Edition by Karch) 5
refer to image
Drug labels are a source of information. What information might a drug label provide?
A. The manufactured date
B. The expiration date
C. When the patent expires
D. The binding properties of the drug
B. The expiration date
over the counter drugs
drugs available to consumers without a prescription
Category A Pregnancy
Studies indicate no risk to the human fetus
Category B pregnancy
No risk to fetus according to animal studies, but there are no adequate human studies
Category C pregnancy
Risk to fetus has been found in animal studies OR there are no good animal studies or human studies
Category D pregnancy
There is evidence of human fetal risk, but the potential benefits from the use of the drug in pregnant women
may be acceptable despite its potential risks.
Category X pregnancy
tolerance
what is the most common route of drug administration in the body?
oral- can be affected by prescience of food in stomach
Distribution routes- way the drugs travel through the body's tissues
Protein Binding
Blood Brain Barrier
Placenta/Breast Milk
in most cases, drugs are best taken on an __, which means an hour before meals, and two after
empty stomach
Excretion
Removal of drugs from the body
Kidneys play the most important role
Two patients are receiving injections of penicillin G. One patient is a male, 35 years old, weighing 165
pounds.
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