1i|iP a g e
, ONS/ONCC Chemotherapy Immuno i i
therapy CertificateAlready Passed
i i i
Lessoni1:iFoundationsitoiSetitheiStagei✔✔
FocusingioniCellulariStructureiandiFunctioni✔✔
Thei Normali Celli Cyclei ✔✔-
Thei celli cyclei refersi toi thei orderedi seresi ofi processesi ofi DNAireplicationiandimitosis,ioricellidi
vision
-
Celli nucleusi regulatesi thesei processesi byi gatheringi andi processingi complexesi moleculariinfor
mation
Interphasei andi Mitotici Phasei ✔✔Celli divisioni producesi twoi identicali cellsi throughi thesei twoimajo
riphases
Duringiinterphase:i✔✔CelligrowsiandiDNAiisireplicatedithroughitheifollowingithreeisteps:i1:i
Firstigrowthiphasei(G1iorifirstigap)
2:iSynthesisiphasei(Siphase)i3:Mitoti
ciPhsei(Miphase)
FirstiGrowthiPhasei(G1iorifirstigap)i✔✔-cellsiincreaseiinisize
2i|iP a g e
,-reproduceiRNA
3i|iP a g e
, -"qualityiassurance"itestithatitheicelliwillibeireadyitoisynthesisiDNA
-Lengthiofitimeiisivariable,icanibeifromihoursitoidays
SynthesisiPhasei(Siphase)i✔✔-DNAireplicates
-ResultsiinitheiformationiofiidenticalipairsiofiDNAi(chromatids)
-whichiareiattachediaititheicentromere
-lastsi2-10ihours
MitoticiPhasei(Miphase)i✔✔-
Replicatedichromosomesiareialigned,iseparated,iandimoveiintoi2inew,iidenticalidaughtericells
-takesiabouti30-60iminutes
Majoripointsioficelliregulationiareientryiandiexitifromi✔✔-G1icheckpoint
-SiPhase
-G2icheckpoint
-Miphase
RestrictioniPointi✔✔-Theitransitionifromitheirestingiphaseiintoianiactivelyidividingiphasei(G0-
iG1)iisiaipointiwhereicellularitransformationicanioccur
-Duringithisitime,icellsipassithroughiaitransitioniphaseiknowniasiairestrictionipoint
4i|iP a g e
, ONS/ONCC Chemotherapy Immuno i i
therapy CertificateAlready Passed
i i i
Lessoni1:iFoundationsitoiSetitheiStagei✔✔
FocusingioniCellulariStructureiandiFunctioni✔✔
Thei Normali Celli Cyclei ✔✔-
Thei celli cyclei refersi toi thei orderedi seresi ofi processesi ofi DNAireplicationiandimitosis,ioricellidi
vision
-
Celli nucleusi regulatesi thesei processesi byi gatheringi andi processingi complexesi moleculariinfor
mation
Interphasei andi Mitotici Phasei ✔✔Celli divisioni producesi twoi identicali cellsi throughi thesei twoimajo
riphases
Duringiinterphase:i✔✔CelligrowsiandiDNAiisireplicatedithroughitheifollowingithreeisteps:i1:i
Firstigrowthiphasei(G1iorifirstigap)
2:iSynthesisiphasei(Siphase)i3:Mitoti
ciPhsei(Miphase)
FirstiGrowthiPhasei(G1iorifirstigap)i✔✔-cellsiincreaseiinisize
2i|iP a g e
,-reproduceiRNA
3i|iP a g e
, -"qualityiassurance"itestithatitheicelliwillibeireadyitoisynthesisiDNA
-Lengthiofitimeiisivariable,icanibeifromihoursitoidays
SynthesisiPhasei(Siphase)i✔✔-DNAireplicates
-ResultsiinitheiformationiofiidenticalipairsiofiDNAi(chromatids)
-whichiareiattachediaititheicentromere
-lastsi2-10ihours
MitoticiPhasei(Miphase)i✔✔-
Replicatedichromosomesiareialigned,iseparated,iandimoveiintoi2inew,iidenticalidaughtericells
-takesiabouti30-60iminutes
Majoripointsioficelliregulationiareientryiandiexitifromi✔✔-G1icheckpoint
-SiPhase
-G2icheckpoint
-Miphase
RestrictioniPointi✔✔-Theitransitionifromitheirestingiphaseiintoianiactivelyidividingiphasei(G0-
iG1)iisiaipointiwhereicellularitransformationicanioccur
-Duringithisitime,icellsipassithroughiaitransitioniphaseiknowniasiairestrictionipoint
4i|iP a g e
