Test bank 4 for Janeways Immunobiology 9th Edition by Kenneth Murphy Casey Weaver 9780815345053

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Janeway's Immunobiology, 9th Edition (Murphy, 2017)
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Fundamentals Of Nursing (Joseph F. McCloskey School of Nursing)
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JANEWAY'S IMMUNOBIOLOGY, 9TH EDITION CHAPTE
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R 1: BASIC CONCEPTS IN IMMUNOLOGY
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The origins of vertebrate immune cells
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1.1 Multiplecchoice:cIncpatientscwithclymphomas,ctheccancerccellscinvadecthecbonecmarrowca
ndcdestroycthecenvironmentcrequiredcforcnormalchematopoiesis.cThiscleadsctocbonecmarro
wcfailure,cwhichcdisruptscthecproductioncofchematopoieticccellclineages.cAllcofcthecfollowing
ccellctypescwouldcbecaffectedcbycthiscEXCEPT:

A. Redcbloodccells
B. Macrophages
C. Lymphocytes
D. Endothelialccells
E. Granulocytes

Principles of innate immunity
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1-1 Commensalcorganismsccauseclittlechostcdamagecwhilecpathogenscdamagechostct
issuescbycacvarietycofcmechanisms

1.2 True/False:cOurcimmunecsystemcefficientlyckillscallccategoriescofcmicrobescthatcattemptctocc
olonizecourcbodies.
WWW.TBSM.WS
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1.3 Shortcanswer:cPathogeniccorganisms causec damagec tocthechostcbycacvarietycofcmechan
Wcof
WcW .cpathogen
T B S M .cand
W Scitscmodecofcreplicationcin
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isms,cdependingconctheccategory the
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thechost.cGivecancexamplecofctwocdifferentctypescofcpathogenscthatcarecunlikelyctocbecdealtc
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withcbycthecsamecmechanismcofcimmunecprotection.
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1-2 Anatomiccandcchemicalcbarrierscarecthecfirstcdefensecagainstcpathogens
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1.4 Multiplecchoice:cThecskincandcbodilycsecretionscprovidecthecfirstclinecofcdefensecagainstci
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nfection.cOnecresponsecincthisccategorycthatcisccommoncduringcuppercrespiratorycviruscinfe
ctionscis:
A. Productioncofcantibodies
B. Infiltrationcbycwhitecbloodccells
C. Mucuscproduction
D. Increasedcsalivacproduction
E. Fever

1-3 Thecimmunecsystemciscactivatedcbycinflammatorycinducerscthatcindicatecthecpresenceco
fcpathogenscorctissuecdamage

1.5 Shortcanswer:cAccommoncmechanismcbycwhichcsensorccellscincthechostcdetectcmicro-
corganismscreliesconcthecproductioncof cuniquecmicrobialccomponentscnotcfoundcincthechos

t.cProposecacstrategycbycwhichcacclevercmicrobeccouldcevadecthisctypecofcresponse.

1.6 Multiplecchoice:cAdaptivecimmunecresponsescarecslowctocdevelop,ctakingcdaysctocweeksca
ftercexposurectocreachctheircpeak.cHowever,cthesecresponsescarecmorecspecificcthancinnatec
responses,candcalsocgeneratecimmunologicalcmemory.cTheseclattercfeatures,



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whichcprovidecenhancedcprotectioncuponcre-
infectioncwithcthecsamecpathogen,carecthecbasiscof:
A. Vaccines
B. Antibiotics
C. Systemiccshock
D. Complementcactivation
E. Phagocytosis

1-4 Thecmyeloidclineageccomprisescmostcofctheccellscofcthecinnatecimmunecsystem

1.7 True/False:cIncthecabsencecofcancinfection,cmostcgranulocytesc(neutrophils,ceosinophils,c
basophils)carecfoundccirculatingcincthecblood,cwhereascothercsubsetscofcmyeloidccellscresid
ecinctissues.

1.8 Shortcanswer:cDendriticccellscarecphagocytic,cbutcalsoccapablecofcingestingclargecamounts
cof cextracellularcfluidcandcitsccontents,cacprocesscknowncascmacropinocytosis.cWhatcspecial

izedcfunctioncdocdendriticccellschavecincimmunitycthatcmightcaccountcforctheircneedctocperfor
mcmacropinocytosis?

1-5 Sensorccellscexpresscpatterncrecognitioncreceptorscthatcprovidecancinitialc
discriminationcbetweencselfcandcnonself

1.9 Multiplecchoice:cSomecPatterncRecognitioncReceptorsc(PRRs)crecognizecnucleiccacids,cli
WWW.TBSM.WS




kecRNAcorcDNA.cSincecourcownccellsccontainchumancRNAcandcDNA,cthecactivationcofcinnat
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ecimmunecpathwayscbycthesecPRRscmustcrelyconcadditionalccriteriactocdiscriminatecselfcfro
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mcnonself.cAdditionalcc r i t W
e r iWa cW
in.
cluTdB
ecS
evM
er.
ytW SgcEXCEPT:
hin
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A. ThecsubcellularclocationcofcthecRNA
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B. ThecpresencecofcadenosinecresiduescincviralcRNA
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C. ThecmethylationcstatecofcthecDNA
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D. UniquecstructurescfoundconcviralcRNA
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E. ThecsubcellularclocationcofcthecDNA
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1-6 Sensorccellscinducecancinflammatorycresponsecbycproducingcmediatorscsuchcascc
hemokinescandccytokines

1.10 Multiplecchoice:cWhencmacrophagescincactissuecencountercbacteria,ctheycreleaseccytoki
nescthatcinducecancinflammatorycresponse.cTheseccytokinescactconcothercimmuneccells,ct
ocrecruitcthemctocthecsitecofcinfectioncandctocenhancectheircactivities.cIncaddition,ctheseccyt
okinescactconcthecendothelialccellscofcthecbloodcvesselcwallcto:
A. Increasectheircpermeability,callowingcfluidcandcproteinsctocleakcintocthectissue
B. Solidifycthectightcjunctionsctocpreventcthecbacteriacfromcenteringcthecblood
C. Proliferate,callowingcthecbloodcvesselctocenlarge
D. Up-regulatecmicrobicidalcmechanisms,csoctheyccanckillcbacteria
E. Secretecanti-microbialcpeptides

1.11 Shortcanswer:cAccommonccharacteristiccofcacsitecofcinfection,csuchcascacpimpleconcthecs
kin,ciscpus.cWhatciscresponsiblecforcthecwhiteccolorcofcpus?

1-7 Innateclymphocytescandcnaturalckillerccellscareceffectorccellscthatcsharecsimilaritiesc
withclymphoidclineagescofcthecadaptivecimmunecsystem



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