Pharmacology and Pharmacokinetics of Int
w w w w w
ravenous Drugs Questions with detailed
w w w w w
Answers at the End
w w w
Questionswonwpharmacologywandwdrugwusedwinwanesthesiaworwrelatedwtowanesthesia.
induction agents; muscle relaxants; antibiotics; antihypertensi
w w w w w
ves
169. Whichwofwthewfollowingwmusclewrelaxantswisweliminatedwthewmostwbywren
alwexcretion?
A. Pancuronium
B. Vecuronium
C. Atracurium
D. Rocuronium
170. Allwofwthewfollowingwconditionswmaywdevelopwwhenwusingwpropofolwf
orwprolongedwsedationwinwthewintensivewcarewunitw(ICU)wEXCEPT
A. Pancreatitis
B. Hyperlipidemia
C. Metabolicwacidosis
D. Adrenalwsuppression
171. Underwwhichwscenariowshouldwdantrolenewbewwithheldwinwawpatientwinwwho
mwmalignantwhyperthermiaw(MH)wiswsuspected?
A. Concomitantwtreatmentwwithwawcalciumwchannelwblocker
, B. Historywofwpreviouswuneventfulwanestheticwwithwvolatilewanesthetic
C. Historywofwnegativewgeneticwtestwforwryanodinewmutation
D. Never
172. Aw78-year-
oldwpatientwwithwParkinsonwdiseasewundergoeswawcataractwoperationwunderwge
neralwanesthesia.wInwthewrecoverywroom,wthewpatientwhaswtwowepisodeswofweme
siswandwcomplainswofwseverewnausea.wWhichwofwthewfollowingwantiemeticsww
ouldwbewthewbestwchoicewforwtreatmentwofwnauseawinwthiswpatient?
A. Droperidol
B. Promethazine
C. Ondansetron
D. Metoclopramide
173. Whichwofwthewfollowingwdiseaseswiswassociatedwwithwincreasedwresistancewt
owneuromuscularwblockadewwithwsuccinylcholine?
A. Myastheniawgravis
B. Myasthenicwsyndrome
C. Huntingtonwchorea
D. Polymyositis
174. Sedationwwithwwhichwofwthewfollowingwdrugswiswmostwlikelywtowresemblewnorm
alwsleep?
A. Propofol
B. Midazolam
C. Dexmedetomidine
D. Ketamine
175. Whichwofwthewfollowingwintravenouswanestheticswiswconvertedwfromwawwate
r-wsolublewtowawlipid-solublewdrugwafterwexposurewtowthewbloodstream?
A. Propofol
B. Midazolam
C. Ketamine
D. Nonewofwthewabove
176. Aw33-year-old,w70-
kgwpatientwiswbroughtwtowthewoperatingwroomwforwresectionwofwanwanteriorwpituit
arywprolactin-
secretingwtumor.wAnesthesiawiswinducedwwithwsevoflurane,wnitrouswoxide,wandw
oxygen.wThewpatientwiswintubated,wandwnitrouswoxidewiswdiscontinued.wAnesthe
siawiswmaintainedwwithw1.2wminimumwalveolarwconcentrationw(MAC)wsevoflur
anewinwoxygen.wThewsurgeonwplanswtowinjectwepinephrinewintowthewnasalwmucos
awtowminimizewbleeding.wWhatwiswthewmaximumwvolumewofwaw1:100,000wepine
phrinewsolutionwthatwcanwbewadministeredwsafelywtowthiswpatientwwithoutwprodu
cingwventricularwarrhythmias?
A. 55wmL
B. 45wmL
C. 35wmL
D. 25wmL
,177. Patientswreceivingwantihypertensivewtherapywwithwpropranololwarewatwincrease
dwriskwforweachwofwthewfollowingwEXCEPT
A. Bluntedwresponsewtowhypoglycemia
B. Bronchoconstriction
C. Reboundwtachycardiawafterwdiscontinuation
D. Orthostaticwhypotension
178. AtropinewcausesweachwofwthewfollowingwEXCEPT
A. Decreasedwgastricwacidwsecretion
B. Inhibitionwofwsalivarywsecretion
C. Increasedwlowerwesophagealwsphincterwtone
D. Mydriasis
179. Whichwofwthewfollowingwdrugswiswcapablewofwcrossingwthewblood-brainwbarrier?
A. Neostigmine
B. Pyridostigmine
C. Edrophonium
D. Physostigmine
180. Whichwdrugwexertswitswmainwcentralwnervouswsystemw(CNS)wactionwbywinhibitin
gwthewNw-methyl-D-aspartatew(NMDA)wreceptors?
A. Propofol
B. Midazolam
C. Etomidate
D. Ketamine
181. Whichwofwthewfollowingwopioid-
receptorwagonistswhaswanticholinergicwproperties?
A. Morphine
B. Hydromorphone
C. Sufentanil
D. Meperidine
182. WhichwofwthewfollowingwstatementswaboutwketaminewiswFALSE?
A. InwthewUnitedwStateswitwiswawracemicwmixturewofwtwowisomers
B. Itwiswawpotentwcerebralwvasodilatorwandwcanwincreasewintracrani
alwpressurew(ICP)
C. Respiratorywdepressionwrarelywoccurswwithwinductionwdoses
D. Itswmetabolitewnorketaminewiswmorewpotentwthanwthewparen
twcompound
183. Whichwofwthewfollowingwvasopressorwagentswincreaseswsystemicwbloodwpressur
ew(BP)windirectlywbywstimulatingwthewreleasewofwnorepinephrinewfromwsympath
eticwnervewfiberswandwdirectlywbywbindingwtowadrenergicwreceptors?
A. Vasopressin
B. Ephedrine
C. Epinephrine
D. Phenylephrine
, 184. Methadone-
inducedwconstipationwcouldwbewreversedwwithoutwlosswofwanalgesicweffectwwit
hwwhichwofwthewfollowingwopioidwantagonists?
A. Naloxone
B. Nalmefene
C. Naltrexone
D. Methylnaltrexone
185. Thewtreatmentwofwpatientswwithwhumanwimmunodeficiencywvirusw(HIV)wma
ywincludewindinavir,wnelfinavir,worwritonavir.wWhatwanestheticwconsideratio
nwiswsignificantwwithwthesewdrugs?
A. Decreasedwplateletwfunction
B. Increasedwsensitivitywtowmidazolam
C. Hypoglycemia
D. Hyperkalemia
186. Neurokinin-
1w(NK1)wantagonistswsuchwaswaprepitantwhavewallwthewfollowingwproperties
wEXCEPT
A. Anxiolytic
B. Antidepressant
C. Analgesic
D. Antiemetic
187. Whichwofwthewfollowingwdrugswshouldwbewadministeredwwithwcautionwtowpatien
tswreceivingwechothiophatewforwthewtreatmentwofwglaucoma?
A. Atropine
B. Succinylcholine
C. Ketamine
D. Remifentanil
188. Whenwonewofwfourwthumbwtwitcheswinwthewtrain-of-
fourw(TOF)wstimulationwofwthewulnarwnervewcanwbewelicited,whowwmuchwsuppr
essionwwouldwtherewbewifwyouwwerewmeasuringwawsinglewtwitch?
A. 20wtow25
B. 45wtow55
C. 75wtow80
D. 90wtow95
189. Whichwofwthewfollowingwmusclewrelaxantswcauseswslightwhistaminewreleasew
atwtwowtowthreewtimeswthewED95w (effectivewdosewinw95%wofwsubjects)wdose?
A. Rocuronium
B. Pancuronium
C. Atracurium
D. Cisatracurium
190. Terminationwofwactionwofwthewneurotransmitterwnorepinephrinewiswachieve
dwpredominatelywbywwhichwmechanism?
A. Reuptakewintowpostganglionicwsympatheticwnervewendingsw(uptak
ew1)
w w w w w
ravenous Drugs Questions with detailed
w w w w w
Answers at the End
w w w
Questionswonwpharmacologywandwdrugwusedwinwanesthesiaworwrelatedwtowanesthesia.
induction agents; muscle relaxants; antibiotics; antihypertensi
w w w w w
ves
169. Whichwofwthewfollowingwmusclewrelaxantswisweliminatedwthewmostwbywren
alwexcretion?
A. Pancuronium
B. Vecuronium
C. Atracurium
D. Rocuronium
170. Allwofwthewfollowingwconditionswmaywdevelopwwhenwusingwpropofolwf
orwprolongedwsedationwinwthewintensivewcarewunitw(ICU)wEXCEPT
A. Pancreatitis
B. Hyperlipidemia
C. Metabolicwacidosis
D. Adrenalwsuppression
171. Underwwhichwscenariowshouldwdantrolenewbewwithheldwinwawpatientwinwwho
mwmalignantwhyperthermiaw(MH)wiswsuspected?
A. Concomitantwtreatmentwwithwawcalciumwchannelwblocker
, B. Historywofwpreviouswuneventfulwanestheticwwithwvolatilewanesthetic
C. Historywofwnegativewgeneticwtestwforwryanodinewmutation
D. Never
172. Aw78-year-
oldwpatientwwithwParkinsonwdiseasewundergoeswawcataractwoperationwunderwge
neralwanesthesia.wInwthewrecoverywroom,wthewpatientwhaswtwowepisodeswofweme
siswandwcomplainswofwseverewnausea.wWhichwofwthewfollowingwantiemeticsww
ouldwbewthewbestwchoicewforwtreatmentwofwnauseawinwthiswpatient?
A. Droperidol
B. Promethazine
C. Ondansetron
D. Metoclopramide
173. Whichwofwthewfollowingwdiseaseswiswassociatedwwithwincreasedwresistancewt
owneuromuscularwblockadewwithwsuccinylcholine?
A. Myastheniawgravis
B. Myasthenicwsyndrome
C. Huntingtonwchorea
D. Polymyositis
174. Sedationwwithwwhichwofwthewfollowingwdrugswiswmostwlikelywtowresemblewnorm
alwsleep?
A. Propofol
B. Midazolam
C. Dexmedetomidine
D. Ketamine
175. Whichwofwthewfollowingwintravenouswanestheticswiswconvertedwfromwawwate
r-wsolublewtowawlipid-solublewdrugwafterwexposurewtowthewbloodstream?
A. Propofol
B. Midazolam
C. Ketamine
D. Nonewofwthewabove
176. Aw33-year-old,w70-
kgwpatientwiswbroughtwtowthewoperatingwroomwforwresectionwofwanwanteriorwpituit
arywprolactin-
secretingwtumor.wAnesthesiawiswinducedwwithwsevoflurane,wnitrouswoxide,wandw
oxygen.wThewpatientwiswintubated,wandwnitrouswoxidewiswdiscontinued.wAnesthe
siawiswmaintainedwwithw1.2wminimumwalveolarwconcentrationw(MAC)wsevoflur
anewinwoxygen.wThewsurgeonwplanswtowinjectwepinephrinewintowthewnasalwmucos
awtowminimizewbleeding.wWhatwiswthewmaximumwvolumewofwaw1:100,000wepine
phrinewsolutionwthatwcanwbewadministeredwsafelywtowthiswpatientwwithoutwprodu
cingwventricularwarrhythmias?
A. 55wmL
B. 45wmL
C. 35wmL
D. 25wmL
,177. Patientswreceivingwantihypertensivewtherapywwithwpropranololwarewatwincrease
dwriskwforweachwofwthewfollowingwEXCEPT
A. Bluntedwresponsewtowhypoglycemia
B. Bronchoconstriction
C. Reboundwtachycardiawafterwdiscontinuation
D. Orthostaticwhypotension
178. AtropinewcausesweachwofwthewfollowingwEXCEPT
A. Decreasedwgastricwacidwsecretion
B. Inhibitionwofwsalivarywsecretion
C. Increasedwlowerwesophagealwsphincterwtone
D. Mydriasis
179. Whichwofwthewfollowingwdrugswiswcapablewofwcrossingwthewblood-brainwbarrier?
A. Neostigmine
B. Pyridostigmine
C. Edrophonium
D. Physostigmine
180. Whichwdrugwexertswitswmainwcentralwnervouswsystemw(CNS)wactionwbywinhibitin
gwthewNw-methyl-D-aspartatew(NMDA)wreceptors?
A. Propofol
B. Midazolam
C. Etomidate
D. Ketamine
181. Whichwofwthewfollowingwopioid-
receptorwagonistswhaswanticholinergicwproperties?
A. Morphine
B. Hydromorphone
C. Sufentanil
D. Meperidine
182. WhichwofwthewfollowingwstatementswaboutwketaminewiswFALSE?
A. InwthewUnitedwStateswitwiswawracemicwmixturewofwtwowisomers
B. Itwiswawpotentwcerebralwvasodilatorwandwcanwincreasewintracrani
alwpressurew(ICP)
C. Respiratorywdepressionwrarelywoccurswwithwinductionwdoses
D. Itswmetabolitewnorketaminewiswmorewpotentwthanwthewparen
twcompound
183. Whichwofwthewfollowingwvasopressorwagentswincreaseswsystemicwbloodwpressur
ew(BP)windirectlywbywstimulatingwthewreleasewofwnorepinephrinewfromwsympath
eticwnervewfiberswandwdirectlywbywbindingwtowadrenergicwreceptors?
A. Vasopressin
B. Ephedrine
C. Epinephrine
D. Phenylephrine
, 184. Methadone-
inducedwconstipationwcouldwbewreversedwwithoutwlosswofwanalgesicweffectwwit
hwwhichwofwthewfollowingwopioidwantagonists?
A. Naloxone
B. Nalmefene
C. Naltrexone
D. Methylnaltrexone
185. Thewtreatmentwofwpatientswwithwhumanwimmunodeficiencywvirusw(HIV)wma
ywincludewindinavir,wnelfinavir,worwritonavir.wWhatwanestheticwconsideratio
nwiswsignificantwwithwthesewdrugs?
A. Decreasedwplateletwfunction
B. Increasedwsensitivitywtowmidazolam
C. Hypoglycemia
D. Hyperkalemia
186. Neurokinin-
1w(NK1)wantagonistswsuchwaswaprepitantwhavewallwthewfollowingwproperties
wEXCEPT
A. Anxiolytic
B. Antidepressant
C. Analgesic
D. Antiemetic
187. Whichwofwthewfollowingwdrugswshouldwbewadministeredwwithwcautionwtowpatien
tswreceivingwechothiophatewforwthewtreatmentwofwglaucoma?
A. Atropine
B. Succinylcholine
C. Ketamine
D. Remifentanil
188. Whenwonewofwfourwthumbwtwitcheswinwthewtrain-of-
fourw(TOF)wstimulationwofwthewulnarwnervewcanwbewelicited,whowwmuchwsuppr
essionwwouldwtherewbewifwyouwwerewmeasuringwawsinglewtwitch?
A. 20wtow25
B. 45wtow55
C. 75wtow80
D. 90wtow95
189. Whichwofwthewfollowingwmusclewrelaxantswcauseswslightwhistaminewreleasew
atwtwowtowthreewtimeswthewED95w (effectivewdosewinw95%wofwsubjects)wdose?
A. Rocuronium
B. Pancuronium
C. Atracurium
D. Cisatracurium
190. Terminationwofwactionwofwthewneurotransmitterwnorepinephrinewiswachieve
dwpredominatelywbywwhichwmechanism?
A. Reuptakewintowpostganglionicwsympatheticwnervewendingsw(uptak
ew1)
