Mechanisms of Apoptosis and Tumor Resistance in
Cancer Study questions all Solved 100% CORRECT/
Answers
FLIP - ✔✔Inhibitor upregulated by tumors to evade apoptosis.
ATM/ATR signaling pathway - ✔✔Pathway activating p53 in response to DNA damage.
Bcl2 - ✔✔Anti-apoptotic protein frequently overexpressed in cancers.
Bax - ✔✔Pro-apoptotic protein promoting apoptosis via mitochondrial release.
Bak - ✔✔Pro-apoptotic protein involved in mitochondrial apoptosis.
Apaf1 - ✔✔Apoptotic protease-activating factor 1 in apoptosome formation.
Fas receptor - ✔✔Death receptor activated by FasL to induce apoptosis.
DISC - ✔✔Death-inducing signaling complex formed during apoptosis.
p53 - ✔✔Tumor suppressor protein regulating apoptosis and cell cycle.
TRAIL receptor 2 (DR5) - ✔✔Receptor activated by TRAIL to initiate extrinsic apoptosis.
p53AIP - ✔✔p53-regulated protein inducing apoptosis via mitochondrial disruption.
, Cytochrome c - ✔✔Mitochondrial protein released to activate apoptosome.
Apoptosome - ✔✔Complex activating caspase-9 leading to apoptosis.
FADD - ✔✔Adaptor protein recruiting procaspase-8 in apoptotic signaling.
Decoy receptors - ✔✔Receptors binding TRAIL to inhibit apoptosis signaling.
DcR3 - ✔✔Decoy receptor preventing TRAIL from activating death receptors.
Gene silencing - ✔✔Mechanism disrupting Apaf-1 expression via methylation.
IAP family members - ✔✔Proteins inhibiting apoptosis, often overexpressed in tumors.
Ras - ✔✔Oncogene inhibiting apoptosis through various pathways.
PI3K - ✔✔Pathway promoting cell survival and inhibiting apoptosis.
Mdm2 - ✔✔Oncogene inhibiting p53 function and promoting tumor growth.
PTEN - ✔✔Tumor suppressor regulating apoptosis and cell survival.
AKT - ✔✔Kinase promoting cell survival, often upregulated in tumors.
TRAIL - ✔✔A protein that induces apoptosis via death receptors.
Cancer Study questions all Solved 100% CORRECT/
Answers
FLIP - ✔✔Inhibitor upregulated by tumors to evade apoptosis.
ATM/ATR signaling pathway - ✔✔Pathway activating p53 in response to DNA damage.
Bcl2 - ✔✔Anti-apoptotic protein frequently overexpressed in cancers.
Bax - ✔✔Pro-apoptotic protein promoting apoptosis via mitochondrial release.
Bak - ✔✔Pro-apoptotic protein involved in mitochondrial apoptosis.
Apaf1 - ✔✔Apoptotic protease-activating factor 1 in apoptosome formation.
Fas receptor - ✔✔Death receptor activated by FasL to induce apoptosis.
DISC - ✔✔Death-inducing signaling complex formed during apoptosis.
p53 - ✔✔Tumor suppressor protein regulating apoptosis and cell cycle.
TRAIL receptor 2 (DR5) - ✔✔Receptor activated by TRAIL to initiate extrinsic apoptosis.
p53AIP - ✔✔p53-regulated protein inducing apoptosis via mitochondrial disruption.
, Cytochrome c - ✔✔Mitochondrial protein released to activate apoptosome.
Apoptosome - ✔✔Complex activating caspase-9 leading to apoptosis.
FADD - ✔✔Adaptor protein recruiting procaspase-8 in apoptotic signaling.
Decoy receptors - ✔✔Receptors binding TRAIL to inhibit apoptosis signaling.
DcR3 - ✔✔Decoy receptor preventing TRAIL from activating death receptors.
Gene silencing - ✔✔Mechanism disrupting Apaf-1 expression via methylation.
IAP family members - ✔✔Proteins inhibiting apoptosis, often overexpressed in tumors.
Ras - ✔✔Oncogene inhibiting apoptosis through various pathways.
PI3K - ✔✔Pathway promoting cell survival and inhibiting apoptosis.
Mdm2 - ✔✔Oncogene inhibiting p53 function and promoting tumor growth.
PTEN - ✔✔Tumor suppressor regulating apoptosis and cell survival.
AKT - ✔✔Kinase promoting cell survival, often upregulated in tumors.
TRAIL - ✔✔A protein that induces apoptosis via death receptors.
