DAB Test 2 Questions & Answers
2024/2025
DA depletion in which brain area will suppress amphetamine-induced stereotypy but enhance
apomorphine-induced stereotypy? - ANSWERSnucleus accumbens and caudate/putamen (neostriatum
or "striatum") --> basal ganglia
substantia niagra
Why is apomorphine stereotypy enhanced after DA depletion? - ANSWERSreceptor sensitivity; the
increase in receptor number is a homeostatic response to the DA depletion
postsynaptic receptor cells make more receptors
Which DA system is degenerating most heavily in Parkinson's disease? - ANSWERSneostriatum
(caudate/putamen), also in accumbens
What is the most common drug treatment for Parkinson's disease? - ANSWERSL-DOPA
Name some common drugs of abuse that can produce psychotic reactions similar to schizophrenia. -
ANSWERSL-DOPA psychosis, amphetamine psychosis, cocaine psychosis, PCP (phencyclidine, 'Angel
Dust,' PCP psychosis is the one that most closely resembles schizophrenia)
stimulant drugs that enhance DA transmission
Most antipsychotic drugs are antagonists of __________ receptors. Which subtype of receptor for this
transmitter is most closely linked to this effect? - ANSWERSDA
DA D2 partial agonists
, Name some of the positive symptoms of schizophrenia. - ANSWERSdelusions, hallucinations,
disorganized speech
Most drugs used to treat schizophrenia commonly induce symptoms of which neurological disorder? -
ANSWERSParkinson's (most common; typically treated with muscarinic antagonists [Cogentin, Artane])
Name an atypical antipsychotic drug. - ANSWERSclozapine (Clozaril)
is antipsychotic, but produces little in the way of motor side effects; it is antiparkinsonian
is very effective in some patients that don't respond to other drugs, and on symptoms that don't
respond well to other drugs (eg. cognitive symptoms)
one problem - it can kill you. produces a blood disorder that reduces white blood cells known as
granulocytes which impairs immune system function
Name a drug that can block the antidepressant effect of a NE uptake blocker. - ANSWERStricyclics -
imipramine (tofranil), desipramine (norpramine), trimipramine (surmontil), amytriptyline (elavil)
first generation of antidepressant drugs
these drugs all block monoamine uptake, which acts on NE
alpha methyl tyrosine blocks CA synthesis and effect of NE uptake blocker
Of the 5 stages of neural transmission (synthesis, storage release, postsynaptic activation, inactivation),
which one is usually targeted by antidepressant drugs? - ANSWERSantidepressants act to elevate levels
of 1 or more amines by blocking inactivation
If a drug blocks MAO or inhibits monoamine uptake (i.e., transport) what effect would it have on
monoamine transmission? - ANSWERSdecrease in MA transmission is related to depression, but
2024/2025
DA depletion in which brain area will suppress amphetamine-induced stereotypy but enhance
apomorphine-induced stereotypy? - ANSWERSnucleus accumbens and caudate/putamen (neostriatum
or "striatum") --> basal ganglia
substantia niagra
Why is apomorphine stereotypy enhanced after DA depletion? - ANSWERSreceptor sensitivity; the
increase in receptor number is a homeostatic response to the DA depletion
postsynaptic receptor cells make more receptors
Which DA system is degenerating most heavily in Parkinson's disease? - ANSWERSneostriatum
(caudate/putamen), also in accumbens
What is the most common drug treatment for Parkinson's disease? - ANSWERSL-DOPA
Name some common drugs of abuse that can produce psychotic reactions similar to schizophrenia. -
ANSWERSL-DOPA psychosis, amphetamine psychosis, cocaine psychosis, PCP (phencyclidine, 'Angel
Dust,' PCP psychosis is the one that most closely resembles schizophrenia)
stimulant drugs that enhance DA transmission
Most antipsychotic drugs are antagonists of __________ receptors. Which subtype of receptor for this
transmitter is most closely linked to this effect? - ANSWERSDA
DA D2 partial agonists
, Name some of the positive symptoms of schizophrenia. - ANSWERSdelusions, hallucinations,
disorganized speech
Most drugs used to treat schizophrenia commonly induce symptoms of which neurological disorder? -
ANSWERSParkinson's (most common; typically treated with muscarinic antagonists [Cogentin, Artane])
Name an atypical antipsychotic drug. - ANSWERSclozapine (Clozaril)
is antipsychotic, but produces little in the way of motor side effects; it is antiparkinsonian
is very effective in some patients that don't respond to other drugs, and on symptoms that don't
respond well to other drugs (eg. cognitive symptoms)
one problem - it can kill you. produces a blood disorder that reduces white blood cells known as
granulocytes which impairs immune system function
Name a drug that can block the antidepressant effect of a NE uptake blocker. - ANSWERStricyclics -
imipramine (tofranil), desipramine (norpramine), trimipramine (surmontil), amytriptyline (elavil)
first generation of antidepressant drugs
these drugs all block monoamine uptake, which acts on NE
alpha methyl tyrosine blocks CA synthesis and effect of NE uptake blocker
Of the 5 stages of neural transmission (synthesis, storage release, postsynaptic activation, inactivation),
which one is usually targeted by antidepressant drugs? - ANSWERSantidepressants act to elevate levels
of 1 or more amines by blocking inactivation
If a drug blocks MAO or inhibits monoamine uptake (i.e., transport) what effect would it have on
monoamine transmission? - ANSWERSdecrease in MA transmission is related to depression, but
