611 Exam 3 | UPDATE|COMPREHENSIVE C. Maturation in drug transporters that impact
QUESTIONS AND VERIFIED central nervous system penetration
SOLUTIONS/CORRECT ANSWERS|GET 100% D. Maturation in renal clearance
ACCURATE!!
B
Gastric emptying rate reaches adult capacity by
what age?
A. 1 year of age
B. 1 month of age
C. 6-8 months of age
D. 2 years of age
Terms in this set (64)
C
Original
Which of the following factors can alter drug
SL is a 31 week gestational age infant. She was distribution in infants?
born two weeks ago. Her birthweight is 1.5 A. Less skin hydration
kilograms. What is SL's post-natal and post- B. Changes in total body water and total body
menstrual age? fat with age
A. 2 weeks post-natal age; 29 weeks post- C. Drug-drug interactions that lead to drug
menstrual age metabolism inhibition
B. 2 weeks post-natal age; 33 weeks post- D. Differences in bacterial colonization of the
menstrual age intestines
C. 31 weeks post-natal age; 2 weeks post-
menstrual age B
D. 31 weeks post-natal age; 33 weeks post-
The binding of drugs to plasma proteins
menstrual age
depends on which of the following factors?
E. 29 weeks post-natal age; 31 weeks post-
A. Binding affinity for the protein
menstrual age
B. Timing of drug administration
B C. Maturation in the expression of drug
metabolizing enzymes
A neonate is defined as having what post-natal D. Gastric pH
age?
A. <2 years of age A
B. ≤4 weeks of age
The pharmacological action of a drug is
C. <121 days of age
attributed to which of the following?
D. <1 year of age
A. Plasma protein bound drug concentrations
B B. Unbound drug concentrations
Which of the following could potentially alter B
the rate or extent of absorption in infants and
Which of the following is true regarding renal
neonates relative to adults?
function in infants?
A. Maturation in plasma proteins that bind to
A. Renal blood flow reaches adult values by 1
drugs
month of age
, B. Dosing recommendations for renally The _____ age is calculated by subtracting the
eliminated drugs typically do not depend on number of weeks born before 40 weeks from
post-natal age the post-natal age
C. Near adult values in glomerular filtration rate
corrected
are reached by 2 weeks after birth
D. Tubular secretion and reabsorption processes What is the corrected age of a child who is 28
are immature at birth months old (post-natal age) and was born at 28
weeks gestational age? (in months)
D
25 months
Which of the following equations is used
commonly to estimate creatinine clearance in Put the appropriate age type for each box (in
the pediatric population? alphabetical order)
A. Schwartz formula
B. Cockcroft-Gault formula postmenstrual age
C. Modification of Diet in Renal Disease (MDRD) gestational age
study formula post-natal age
corrected age
A
Penicillins undergo glomerular filtration and
tubular secretion. Which of the following may What is the "week" range for children born post
be true about the half-life of elimination for term?
penicillins in infants? Greater than or equal to ____ weeks
A. No change in half-life of elimination 42
B. Increased half-life of elimination due to
reduced glomerular filtration and tubular What is the "week" range for children born full
secretion term?
C. Shorter half-life of elimination due to 38-41 weeks
increased glomerular filtration and tubular
secretion What is the "week" range for children born
moderate-to-late preterm?
B
32-37 weeks (technically not including 37, so 37
The menstrual age is often commonly known as weeks is kinda in a limbo)
the ____ age. It is the time elapsed between the
first day of the last menstrual period and the What is the "week" range for children born very
day of delivery (most commonly reported in preterm?
weeks). The __-__ age is the age since birth
28-32 weeks (not including 32 weeks)
gestational
What is the "week" range for children born
post-natal
extremely preterm? Born before ___ weeks
Postnatal age + gestational age = _______ age
28
postmenstrual
Low birth weight is below ____ kg
Very low birth weight is below ____ kg
Extremely low birth weight is below ____ kg