Medical & Nursing, Dermatology Board
Exam Questions and Answers on Cutaneous
Immunology, A+ GURANTEED.
1
Q
What are the two main “branches” of innate immunity?
A
Cellular vs non-cellular
2
Q
What cells make up cellular innate immunity?
A
Macrophages, neutrophils, NK cells, mast cells, eosinophils, lymphocytes (especially cytotoxic T-
cells)
3
Q
What are some important components of non-cellular innate immunity?
A
Antimicrobial peptides - cathelicidins and defensins
Cytokines (IL-1, IL-10, IL-12, IFNa, IFNb)
Complement
TLR
4
Q
, What are the 3 primary complement pathways?
A
Classical, alternative, and mannose-binding lectin pathways
5
Q
What is the difference between classical complement and alternative/mannose-binding lectin
pathway activation?
A
Classical requires antibodies (It is activated by Antigen-Ab complexes [IgM or IgG])
6
Q
Which IgG does not activate complement?
A
IgG4
7
Q
In what order (strength) do IgG’s activate complement?
A
IgG3>IgG1>IgG2
8
Q
What are the purposes of the complement cascade?
A
1. opsonization, C3b>>C5b
2. Lyse pathogen (membrane attack complex)
,3. increase chemotaxis (c3a, c5a) known as anaphalaxins.
9
Q
What is the alternative pathway activated by?
A
Viral or bacterial products
10
Q
What is the mannose-binding lectin pathway activated by?
A
Microbial carbohydrates like mannose and other monosaccharides on the bacterial wall
11
Q
What cells are Toll-like receptors mostly expressed on?
A
Dendritic cells and macrophages
12
Q
What pathway does activation of TLR activate?
A
NF-kB (Nuclear factor kappa beta)
13
Q
Which TLR does NOT use MyD88 for intracellular signaling?
, A
TLR3
14
Q
Which TLR is activated by triacylated lipoproteins?
A
TLR1/TLR2
15
Q
Which TLR is activated by diacylated lipoproteins?
A
TLR2/TLR6
16
Q
Which TLR is activated by flagellin?
A
TLR5
17
Q
Which TLR is activated by imidazoquinolines (imiquimod) and ssRNA?
A
TLR7/TLR8
18
Q
Which TLR is activated by CpG DNA?
A
Exam Questions and Answers on Cutaneous
Immunology, A+ GURANTEED.
1
Q
What are the two main “branches” of innate immunity?
A
Cellular vs non-cellular
2
Q
What cells make up cellular innate immunity?
A
Macrophages, neutrophils, NK cells, mast cells, eosinophils, lymphocytes (especially cytotoxic T-
cells)
3
Q
What are some important components of non-cellular innate immunity?
A
Antimicrobial peptides - cathelicidins and defensins
Cytokines (IL-1, IL-10, IL-12, IFNa, IFNb)
Complement
TLR
4
Q
, What are the 3 primary complement pathways?
A
Classical, alternative, and mannose-binding lectin pathways
5
Q
What is the difference between classical complement and alternative/mannose-binding lectin
pathway activation?
A
Classical requires antibodies (It is activated by Antigen-Ab complexes [IgM or IgG])
6
Q
Which IgG does not activate complement?
A
IgG4
7
Q
In what order (strength) do IgG’s activate complement?
A
IgG3>IgG1>IgG2
8
Q
What are the purposes of the complement cascade?
A
1. opsonization, C3b>>C5b
2. Lyse pathogen (membrane attack complex)
,3. increase chemotaxis (c3a, c5a) known as anaphalaxins.
9
Q
What is the alternative pathway activated by?
A
Viral or bacterial products
10
Q
What is the mannose-binding lectin pathway activated by?
A
Microbial carbohydrates like mannose and other monosaccharides on the bacterial wall
11
Q
What cells are Toll-like receptors mostly expressed on?
A
Dendritic cells and macrophages
12
Q
What pathway does activation of TLR activate?
A
NF-kB (Nuclear factor kappa beta)
13
Q
Which TLR does NOT use MyD88 for intracellular signaling?
, A
TLR3
14
Q
Which TLR is activated by triacylated lipoproteins?
A
TLR1/TLR2
15
Q
Which TLR is activated by diacylated lipoproteins?
A
TLR2/TLR6
16
Q
Which TLR is activated by flagellin?
A
TLR5
17
Q
Which TLR is activated by imidazoquinolines (imiquimod) and ssRNA?
A
TLR7/TLR8
18
Q
Which TLR is activated by CpG DNA?
A
