IMMUNE SYSTEM QUESTIONS WITH
100% VERIFIED ANSWERS { GRADED
A+}
DNA virus, member Herpesviridae family
Most common congenital viral infection - ✔✔CMV
transmission of CMV? - ✔✔transplacental
intrapartum
postnatally: breast milk
Maternal infection with CMV during ________ of pregnancy associated
with greater risk of neonatal infection and greater severity of infection -
✔✔first half
, • 85-90% are asymptomatic at birth
• 10-15% are symptomatic at birth
• IUGR, jaundice, hepatosplenomegaly, purpura, dermal
hematopoiesis (blueberry muffin rash), microcephaly,
periventricular calcifications and chorioretinitis
• 90% develop long-term neurodevelopmental sequelae - ✔✔CMV
diagnosis of CMV? - ✔✔Viral culture of urine CMV in the 1st week of
life
treatment of CMV? - ✔✔IV Ganciclovir q12 hours for 6 weeks
or oral Valganciclovir
common adverse effect of ganciclovir? - ✔✔neutropenia
What has the highest sensitivity for CMV diagnosis? - ✔✔urine and
saliva
100% VERIFIED ANSWERS { GRADED
A+}
DNA virus, member Herpesviridae family
Most common congenital viral infection - ✔✔CMV
transmission of CMV? - ✔✔transplacental
intrapartum
postnatally: breast milk
Maternal infection with CMV during ________ of pregnancy associated
with greater risk of neonatal infection and greater severity of infection -
✔✔first half
, • 85-90% are asymptomatic at birth
• 10-15% are symptomatic at birth
• IUGR, jaundice, hepatosplenomegaly, purpura, dermal
hematopoiesis (blueberry muffin rash), microcephaly,
periventricular calcifications and chorioretinitis
• 90% develop long-term neurodevelopmental sequelae - ✔✔CMV
diagnosis of CMV? - ✔✔Viral culture of urine CMV in the 1st week of
life
treatment of CMV? - ✔✔IV Ganciclovir q12 hours for 6 weeks
or oral Valganciclovir
common adverse effect of ganciclovir? - ✔✔neutropenia
What has the highest sensitivity for CMV diagnosis? - ✔✔urine and
saliva
