PHARM EDAPT WEEK 1: Pharmacogenomics Terms in this set (16) Which suggests an increased risk for a genetic disorder? Select all that apply. Mother diagnosed with breast cancer at the age of 45 Aunt diagnosed at 18 with bipolar disorder Father with an adv

PHARM EDAPT WEEK 1: Pharmacogenomics Terms in this set (16) Which suggests an increased risk for a genetic disorder? Select all that apply. Mother diagnosed with breast cancer at the age of 45 Aunt diagnosed at 18 with bipolar disorder Father with an adverse reaction to penicillin Which area of research has the most impact on pharmacogenomics? Genetics Which research topic is most important to pharmacogenomics researchers and clients who take drugs? how drugs are metabolized through the liver Which best describes pharmacogenomics? The study of how genetic makeup impacts drug metabolism A client has a 2d6 enzyme deficiency. How would a drug metabolize through the 2d6 pathway? The drug will metabolize slowly New treatments for cancer include which of the following? Targeted Gene therapy What drug attribute might be affected by a client's genetics? Metabolism of a drug through the cytochrome p450 system Which examples reflect privacy and confidentiality concerns? Select all that apply. The results of genetic testing for cancer markers in a healthy person Family history of a reaction to a specific drug A person's genetic test describing cytochrome p450 enzyme metabolism. A friend of a client calls the office to let the nurse know they are concerned about the dosage level of phenytoin their friend is taking. It is a much higher dose than usual. The nurse notes that the client is a poor metabolizer of phenytoin based on genetic testing. What is the appropriate response? "I will pass this information on to the appropriate person." Metabolizing Pharmacogenomics involves the sciences of.... Pharmacology Genomics Faster Inactive PHARM EDAPT WEEK 1: Pharmacogenomics Variations in enzymes in the liver may change drug potency. If a client does not make enough of an enzyme that metabolizes a drug, how will that affect the client? The drug will be in their system for more time. A client has a high 2d6 polymorphism and requires warfarin because of atrial fibrillation. In reviewing medications, the nurse would expect which conditions to apply? The client requires a higher dose of warfarin. A client recently started taking the antidepressant sertraline (Zoloft). They are experiencing severe side effects. What could be the reasons? Select all that apply. The client is experiencing a medication reaction with another drug. The client is taking too high of a dose, causing an adverse reaction. The client has CYP2d6 polymorphism. The client is allergic to the medication. Julie (pronouns: she/her/hers) and Kim (pronouns: she/her/hers) both take acetaminophen with codeine for chronic low back pain. That drug is metabolized by the cytochrome p450 2d6 pathway. A recent genetic test showed that Julie carries two inactive copies of the CYP2d6 gene. What would the nurse expect to occur to Julie compared to Kim? This will not help Julie's pain as much as Kim's. A client has CYP2d6 low polymorphism. Which statement suggests an understanding of this when being prescribed codeine? "This medication doesn't work for me, it does nothing for my pain." A client is prescribed fluoxetine for depression. Which statement may indicate that this medication will not work for the client and may cause increased side effects? "My mom had a terrible reaction to this medication."