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Summary

Dermatologie toonstra samenvatting

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Gastcollege van arts, ook in de testvision

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hoorcolleges J. Toonstra.
Structuur en functie van de huid.
Anatomie/fysiologie
• Huidoppervlak volwassene 1,73-2,0 m2
• Gewicht incl. onderhuids bindweefsel 15-20 kg
• Totaal 2 miljoen zweetklieren
• Per 1cm2 :
» 100 zweetklieren
» 10 haren
» 15 talgklieren
» 1 meter capillairen
» 3 meter zenuwen
» 1000 tastlichaampjes op vingertoppen
Epidermis
0,05 tot 0,1 mm dik =meerlagig verhoornend plaveiselepitheel Ze bestaat uit 5 lagen:
• Stratum basale
• Stratum spinosum: stekellaag
• Stratum granulosum: korrellaag
• Stratum lucidum: heldere laag (handpalmen, voetzolen)
• Stratum corneum: hoornlaag
Groei van de huid duurt 28 dagen.
Bij psoriasis 7 dagen, hierdoor de schilfers

Wij verliezen 1 miljoen huidschilfers per dag.
Retelijsten  uitstulping epidermis in de dermis (golfpatroon), voor de
voedingsstoffen.
Bij de voetzool op het plaatje hiernaast die je goed de laag van Lucidum
(doorschijnende laag)

6 cellen in de epidermis
 Keratinocyten
o Strak aan elkaar vast met desmosomen.
 Melanocyten
o Komt vanaf een neurale luist, vanaf het ruggenmerg.
o Vorming pigment in melanosomen (4 typen)
 Afkomstig uit neurale lijst tyrosine →DOPA → eumelanine
 (bruinzwart, bij donker gekleurde rassen)
 en in → feomelanine
 (geelrood, meer bij roodharigen en blanken)
o Basaalcellaag,
o 1 melanocyt verzorgt 36 keratinocyten.
 Vorming pigment in melanocyten

Te veel
Benigne (goedaarding): naevus.
Maligne (kwaadaardig) : melanoom.

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Uploaded on
February 14, 2017
Number of pages
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Written in
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SUMMARY

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