NR 566 / NR566 Advanced Pharmacology Care of the Family Midterm Exam Review| Rated A| Latest | Chamberlain

NR 566 / NR566 Advanced Pharmacology Care of the Family Midterm Exam Review| Rated A| Latest | Chamberlain 1. What is onychomycosis? ~ How do we treat? Fungal infection of the nail Terbinafine and itraconazole for 3-6 months ~ Or topical ciclopirox, tavaborole, efinaconazole for 48 weeks 2. What is the first-choice drug for HSV and VZV infections? ~ Acyclovir 3. What is the MoA of acycolovir? ~ Inhibits viral replications by suppressing the synthesis of DNA 4. High doses of PO acyclovir are effective for what type of infection that is generally seen in the elderly? ~ For herpes zoster (shingles) 5. How soon after chickenpox rash onset does PO acyclovir need to be started for it to be effective? ~ Within 24 hours of rash onset 6. What serious adverse effects can Ganciclovir cause? ~ Granulocytopenia and thrombocytopenia ~ Tell pts to report s/s of senmia, leukoctyopenia, and thrombocytopenia such as pallor, fever, chills, bruising, petechiae 7. What should we advise our child-bearing female patients to do following treatment with ganciclovir? ~ Avoid pregnancy during therapy and for 90 days after ending therapy 8. Should acyclovir be renal dosed? ~ Yes 9. Is acyclovir safe in pregnancy? ~ PO is safe ~ Can be used to suppress recurrent genital herpes near term 10. What are the most common adverse effects of acyclovir? ~ N/V/D, HA, vertigo, local burning or stinging 11. What are some topical drugs that treat herpes labialis? ~ Penciclovir, docosanol, and acyclovir 12. What baseline data is needed for acyclovir and valacyclovir? ~ LFT,serum creatinine, BUN, UA, CBC with diff 13. Which hepatitis is transmitted oral-fecal route? ~ Hep A 14. Which is the safest treatment of pregnant women with HepB: ~ Lamivudine and tenofovir 15. Why do we need to rule out HIV before lamivudine is used? ~ Lamivudine is also used to treat HIV and low doses used to treat Hep B may create HIV viruses that are resistant to nucleoside analogs 16. What potential adverse effects may occur with elbasvir/grazoprevir (Zepatier)? ~ Significant ALT elevations ~ Most common are HA, nausea, fatigue, anemia (5%) 17. T/F lamivudine is safe for children 2+ yo? ~ True Lamivudine and entecavir are approved ~ Afedovir and tenofovir are safe for kids 12+ 18. What is the most common side effect that occurs in 50% taking an alfa-interferon? ~ Flu-like syndrome 19. What is the BBW for alfa interferons? ~ May cause or worsen life-threatening disorders like autoimmune, infectious, and ischemic conditions ~ Serious neuro-psychiatric conditions (especially depression) including suicide have occurred 20. Why is ribavirin combined with interferon for treatment of hep C? ~ Improves response rates as ribavirin isn’t effective alone 21. What is the BBW for Ribavirin? ~ May cause hemolytic anemia and cardiac decompression secondary to hemolytic anemia 22. With Ribavirin use in combination with protease inhibitor, how long after treatment is stopped may cause birth control to be ineffective? ~ Up to 6 months after treatment stopped 23. T/F Hep C infection is NOT contraindicated in a breastfeeding mother as long as her nipples are healthy? ~ True as long as nipples are healthy without cracking or bleeding 24. How do we treat CMV? ~ Ganciclovir, valgancyclovir, cidofovir, foscarnet 25. What is the difference between HSV1 and HSV 2: ~ HSV1 is oral, 2 is genital 26. What is ganciclovir approved for? ~ To prevent and treat a CMV infection in immunocompromised patients 27. What is the BBW for cidofovir? ~ Severe renal impairment and can cause neutropenia ~ Teratogenic and carcinogenic in animal studies 28. What kind of electrolyte imbalances can Foscarnet cause? ~ Frequently causes hypocalcemia, hypokalemia, hypomagnesemia, and hypo/hyperphos-phatemia ~ Instruct patients on s/s of low iCal