Samenvatting van het volledige vak farmacologie dus zowel partim I & II (behaald resultaat 19/20)
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Course
Farmacologie
Institution
Universiteit Antwerpen (UA)
Samenvatting van het volledige vak farmacologie dus zowel partim I & II (behaald resultaat 19/20): Dit bevat een uitgebreide samenvatting van Farmacologie gegeven door professor Pieter-Jan Guns & professor Guido De Meyer. De samenvatting bevat al de lessen (deel 1 & 2), informatie uit de cursus en ...
Fibrinolyticum (synthetisch t-PA) - MI (binnen 12u)
activatie plasminogeen tot plasmine klieving
- Herseninfarct (binnen 3u) Stolsel gericht (grote affiniteit voor fibrine)
Alteplase fibrine trombolyse Risico op bloedingen (GIS, hersenen)
geen actief plasmine in circulatie
- DVT, longembool
- Openen van canules, shunts
- Effect als indirect sympaticomimeticum
Stimulatie CZS Narcolepsie (= slaapstoornis) - Hypertensie teniet gedaan door depletie NA (reserpine:
verhindert transport NA naar vesikels)
- Potentiëring door MAO inhibitoren nog
ADHD, hyperactieve kinderen - Tachycardie
meer hypertensie
Indirect sympaticomimeticum: - Bronchodilatatie
Amfetamine
- Opname via uptake 1 (NET) verdringt NA uit
vesikels in neuronen afgebroken door MAO of
- Constipatie
lekkage uit neuron waardoor binding aan receptor
mogelijk
- Inhibitie MAO (inhibitie afbraak NA) - Insomnia
- inhibitie NET (inhibitie reuptake NA) - Remming eetlust
- Acute psychose (hoge dosis)
- Dependentie (euforie)
- Mydriaticum en cycloplegicum
- Tachycardie (geen BD wijziging)
bij oogonderzoek
- Oog: mydriasis, cycloplegie - Ziekte van Parkinson
- GIS: daling motiliteit en tonus
- Relaxatie GSC (blaas, bronchi,…)
- CZS: vermindering tremoren en rigiditeit bij Parkinson
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