ONS/ONCC Chemotherapy Biotherapy
Certification 2022.
Resources - Answer nccn.org
cancer.org
LESSON 1: Cell cycle - Answer g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
mitosis - Answer 4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
apoptosis - Answer programmed cell death
hematopoiesis - Answer formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
Principles of Biotherapy: p51-95 immunology - Answer -defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
immune responses - Answer innate: primary line of defense, non specific, no memory
adaptive: secondary line of defence with specific memry
cytokines - Answer -effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing comunication
between cells of the immune system
-regular antiboddy production and function of b cells
vaccines for cancer prevention - Answer -hep B prevents hepatitis and hepatocellular
carcinoma
-hpv vaccine
filgrastim aka neupogen - Answer SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments for
nonmyeloid malignancies
, tbo-filgramstim/ pegfilgrastim - Answer reduce duration of neutroenia in patients with
non myeloid malignancies
palifermin - Answer IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
sargramostim - Answer aka leukine - patients with AML following chemo to shorten
neutrophil recovery and reduce incidence of infection
IFN gamma - Answer reduce frequency and severity o infections related to
granulomatous disease
aldeleukin - Answer treat renal cell carcinoma and metastatic melanoma
oprevelkin - Answer prevent severe thrombocytopenia and refuce need for platelet
transfusions in patients with nonmyeloid malig
plerixafor - Answer with filgrastim to mobilize hematopoeitc stem cells for collection from
peripheral blood of patients
sipuleucel - Answer castrate resistant prostate cancer
rituximab - Answer rituxan- treatment of relapsed or refractory low grade follicular b cell
NHL_ first line traetment in combo with chemo in patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors,
dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each infusion
immune system - Answer 1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
malignant tumor (cancer) - Answer cell strcuture different from parent tissue, cell
division uncontrolled, loosely adherent, invade neighboring tissue, establish blood
vessels
Approaches to treatment - Answer cure: prolonged absence of disease
control: no further growth
and palliation : comfort
neoadjuvant - Answer therapy in the first step to shrink a tumor before the main
treatment) surgery is given
-chemo, radiation, hormone therapy
Certification 2022.
Resources - Answer nccn.org
cancer.org
LESSON 1: Cell cycle - Answer g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
mitosis - Answer 4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
apoptosis - Answer programmed cell death
hematopoiesis - Answer formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
Principles of Biotherapy: p51-95 immunology - Answer -defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
immune responses - Answer innate: primary line of defense, non specific, no memory
adaptive: secondary line of defence with specific memry
cytokines - Answer -effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing comunication
between cells of the immune system
-regular antiboddy production and function of b cells
vaccines for cancer prevention - Answer -hep B prevents hepatitis and hepatocellular
carcinoma
-hpv vaccine
filgrastim aka neupogen - Answer SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments for
nonmyeloid malignancies
, tbo-filgramstim/ pegfilgrastim - Answer reduce duration of neutroenia in patients with
non myeloid malignancies
palifermin - Answer IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
sargramostim - Answer aka leukine - patients with AML following chemo to shorten
neutrophil recovery and reduce incidence of infection
IFN gamma - Answer reduce frequency and severity o infections related to
granulomatous disease
aldeleukin - Answer treat renal cell carcinoma and metastatic melanoma
oprevelkin - Answer prevent severe thrombocytopenia and refuce need for platelet
transfusions in patients with nonmyeloid malig
plerixafor - Answer with filgrastim to mobilize hematopoeitc stem cells for collection from
peripheral blood of patients
sipuleucel - Answer castrate resistant prostate cancer
rituximab - Answer rituxan- treatment of relapsed or refractory low grade follicular b cell
NHL_ first line traetment in combo with chemo in patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors,
dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each infusion
immune system - Answer 1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
malignant tumor (cancer) - Answer cell strcuture different from parent tissue, cell
division uncontrolled, loosely adherent, invade neighboring tissue, establish blood
vessels
Approaches to treatment - Answer cure: prolonged absence of disease
control: no further growth
and palliation : comfort
neoadjuvant - Answer therapy in the first step to shrink a tumor before the main
treatment) surgery is given
-chemo, radiation, hormone therapy
