Drugs Affecting Blood Coagulation Chapter 48: D

Chapter 48: Drugs Affecting Blood Coagulation Chapter 48: Drugs Affecting Blood Coagulation Copyright © 2017 Wolters Kluwer • All Rights Reserved Upon completion of this chapter, you will be able to: Upon completion of this chapter, you will  Outline the mechanisms by which blood clots dissolve in the body, correlating this information with the actions of drugs used to affect blood clotting.  Describe the therapeutic actions, indications, pharmacokinetics, contraindications, most common adverse reactions, and important drug–drug interactions associated with drugs affecting blood coagulation.  Discuss the use of drugs that affect blood coagulation across the lifespan.  Compare and contrast the prototype drugs aspirin, heparin, urokinase, antihemophilic factor, and aminocaproic acid with other agents used to affect blood coagulation.  Outline the nursing considerations, including important teaching points, for patients receiving drugs used to affect blood coagulation. Copyright © 2017 Wolters Kluwer • All Rights Reserved Blood Vessel Injury Blood Vessel Injury Local vasoconstriction seals off small injury Platelet aggregation forms a platelet plug Hageman factor is activated Intrinsic pathway converts prothrombin to thrombin to seal system Extrinsic pathway clots the blood that has leaked out of the vascular system Copyright © 2017 Wolters Kluwer • All Rights Reserved Thrombus Formation Thrombus Formation Copyright © 2017 Wolters Kluwer • All Rights Reserved Process of Blood Coagulation Process of Blood Coagulation Copyright © 2017 Wolters Kluwer • All Rights Reserved Damaged Vessel Endothelium is a Stimulus to Platelets, Causing Platelet Adhesion