NU 578
UNIT 4 EXAM
University of South Alabama.
High-Yield Qs & Verified Answers
with Rationales
This Exam Features:
This document includes 50 high-yield Exam
questions with verified answers and detailed
rationales for Unit 4 of NU 578 at the University of
South Alabama. It is designed to help students quickly review and
reinforce core concepts likely to appear on assessments. The
structured Q&A format supports focused exam preparation and
strengthens clinical reasoning and test-taking skills.
,### Question 1
Which of the following is a uricosuric agent for the treatment of gout?
A. Probenecid (Benemid)
B. Allopurinol (Zyloprim)
C. Colchicine (Colbenemid)
D. Methylprednisolone
Correct Answer: A. Probenecid (Benemid)
Expert Rationale:
Probenecid is a uricosuric agent that promotes renal excretion of uric acid,
thereby lowering serum urate levels. Allopurinol is a xanthine oxidase
inhibitor that decreases uric acid production, while colchicine is used
primarily for acute gouty flare treatment but is not uricosuric.
Methylprednisolone is a corticosteroid sometimes used in inflammation but
not as a uricosuric.
---
### Question 2
Cautions to the use of Adalimumab for musculoskeletal diseases include:
Select all that apply
A. Heart failure
B. Use of oral contraceptives
C. Lymphoma
D. Multiple sclerosis
,Correct Answers: A. Heart failure, C. Lymphoma, D. Multiple sclerosis
Expert Rationale:
Adalimumab, a TNF-α inhibitor, can exacerbate heart failure and increase the
risk of malignancies (e.g., lymphoma). It may also induce demyelinating
diseases such as multiple sclerosis. There is no specific caution related to oral
contraceptive use.
---
### Question 3
Raloxifene treatment is contraindicated in:
A. Postmenopausal osteoporosis
B. A history of venous thromboembolic events
C. Short-bowel syndrome
D. Breast cancer
Correct Answer: B. A history of venous thromboembolic events
Expert Rationale:
Raloxifene, a selective estrogen receptor modulator (SERM), increases
thromboembolic risk and is contraindicated in patients with a history of VTE.
It is used for osteoporosis prevention and treatment and has protective effects
for breast cancer, making D incorrect.
, ---
### Question 4
Select the correct match of drug and side effect below:
A. Acetaminophen (Tylenol) - renal insufficiency and swelling
B. Ibuprofen (Motrin) - elevated liver enzymes and icterus
C. Celecoxib (Celebrex) - prolonged prothrombin time and occult bleeding
D. Indomethacin (Indocin) - GI bleeds and abdominal distress
Correct Answer: D. Indomethacin (Indocin) - GI bleeds and abdominal
distress
Expert Rationale:
Indomethacin, a non-selective NSAID, commonly causes GI irritation, ulcers,
and bleeding. Acetaminophen is hepatotoxic in overdose but usually not
associated with renal insufficiency unless overdosed. Ibuprofen can affect
renal function but elevated liver enzymes and icterus are less common.
Celecoxib is a COX-2 selective inhibitor less likely to affect prothrombin time
significantly.
---
### Question 5
A patient requests something for arthritic pain but tells you that she is allergic
to sulfa antibiotics. Given her history, you know that she also cannot take the
following:
UNIT 4 EXAM
University of South Alabama.
High-Yield Qs & Verified Answers
with Rationales
This Exam Features:
This document includes 50 high-yield Exam
questions with verified answers and detailed
rationales for Unit 4 of NU 578 at the University of
South Alabama. It is designed to help students quickly review and
reinforce core concepts likely to appear on assessments. The
structured Q&A format supports focused exam preparation and
strengthens clinical reasoning and test-taking skills.
,### Question 1
Which of the following is a uricosuric agent for the treatment of gout?
A. Probenecid (Benemid)
B. Allopurinol (Zyloprim)
C. Colchicine (Colbenemid)
D. Methylprednisolone
Correct Answer: A. Probenecid (Benemid)
Expert Rationale:
Probenecid is a uricosuric agent that promotes renal excretion of uric acid,
thereby lowering serum urate levels. Allopurinol is a xanthine oxidase
inhibitor that decreases uric acid production, while colchicine is used
primarily for acute gouty flare treatment but is not uricosuric.
Methylprednisolone is a corticosteroid sometimes used in inflammation but
not as a uricosuric.
---
### Question 2
Cautions to the use of Adalimumab for musculoskeletal diseases include:
Select all that apply
A. Heart failure
B. Use of oral contraceptives
C. Lymphoma
D. Multiple sclerosis
,Correct Answers: A. Heart failure, C. Lymphoma, D. Multiple sclerosis
Expert Rationale:
Adalimumab, a TNF-α inhibitor, can exacerbate heart failure and increase the
risk of malignancies (e.g., lymphoma). It may also induce demyelinating
diseases such as multiple sclerosis. There is no specific caution related to oral
contraceptive use.
---
### Question 3
Raloxifene treatment is contraindicated in:
A. Postmenopausal osteoporosis
B. A history of venous thromboembolic events
C. Short-bowel syndrome
D. Breast cancer
Correct Answer: B. A history of venous thromboembolic events
Expert Rationale:
Raloxifene, a selective estrogen receptor modulator (SERM), increases
thromboembolic risk and is contraindicated in patients with a history of VTE.
It is used for osteoporosis prevention and treatment and has protective effects
for breast cancer, making D incorrect.
, ---
### Question 4
Select the correct match of drug and side effect below:
A. Acetaminophen (Tylenol) - renal insufficiency and swelling
B. Ibuprofen (Motrin) - elevated liver enzymes and icterus
C. Celecoxib (Celebrex) - prolonged prothrombin time and occult bleeding
D. Indomethacin (Indocin) - GI bleeds and abdominal distress
Correct Answer: D. Indomethacin (Indocin) - GI bleeds and abdominal
distress
Expert Rationale:
Indomethacin, a non-selective NSAID, commonly causes GI irritation, ulcers,
and bleeding. Acetaminophen is hepatotoxic in overdose but usually not
associated with renal insufficiency unless overdosed. Ibuprofen can affect
renal function but elevated liver enzymes and icterus are less common.
Celecoxib is a COX-2 selective inhibitor less likely to affect prothrombin time
significantly.
---
### Question 5
A patient requests something for arthritic pain but tells you that she is allergic
to sulfa antibiotics. Given her history, you know that she also cannot take the
following:
