HESI A2 ADMISSION ASSESSMENT PRACTICE EXAM
2026/2027 Complete Test | Anatomy, Biology, Chemistry,
Grammar, Reading, Math| Actual Questions & Verified Answers
| All Subject Areas | Pass Guarantee
SECTION 1: Anatomy & Physiology (Questions 1-40)
1. Which valve prevents back-flow of blood from the left ventricle into the left
atrium?
A. Tricuspid valve
B. Pulmonary valve
C. Mitral (bicuspid) valve
D. Aortic valve
Correct Answer: C
Rationale: The mitral (bicuspid) valve is located between the left atrium and left
ventricle and closes during ventricular systole to prevent regurgitation.
2. The primary site of nutrient absorption in the digestive tract is the:
A. Stomach
B. Duodenum
C. Ileum
D. Large intestine
Correct Answer: B
Rationale: The duodenum, the first segment of the small intestine, receives chyme and
enzymes, enabling most chemical digestion and early absorption.
, 3. Which structure carries oxygenated blood from the lungs to the heart?
A. Pulmonary artery
B. Pulmonary vein
C. Superior vena cava
D. Coronary sinus
Correct Answer: B
Rationale: Pulmonary veins are the only veins that carry oxygenated blood, returning it
from lungs to the left atrium.
4. Which hormone is released by the posterior pituitary?
A. ACTH
B. TSH
C. Oxytocin
D. Insulin
Correct Answer: C
Rationale: The posterior pituitary stores and releases oxytocin and ADH; other choices
are anterior pituitary hormones or pancreatic.
5. The functional unit of the kidney responsible for filtration is the:
A. Nephron
B. Collecting duct
C. Loop of Henle
D. Glomerulus
Correct Answer: A
Rationale: The nephron is the smallest functional unit performing filtration, reabsorption,
and secretion; glomerulus is a component.
6. Which type of joint is the shoulder?
A. Hinge
, B. Pivot
C. Ball-and-socket
D. Saddle
Correct Answer: C
Rationale: The shoulder (humerus-scapula) allows multiaxial movement typical of a
ball-and-socket joint.
7. In which layer of the skin are sebaceous glands located?
A. Stratum corneum
B. Dermis
C. Hypodermis
D. Epidermis
Correct Answer: B
Rationale: Sebaceous glands are in the dermis, often connected to hair follicles.
8. Which chamber of the heart has the thickest myocardial wall?
A. Right atrium
B. Left atrium
C. Right ventricle
D. Left ventricle
Correct Answer: D
Rationale: The left ventricle generates systemic pressure, requiring thicker muscle.
9. Which blood cell type is primarily responsible for antibody production?
A. Neutrophil
B. Monocyte
C. B lymphocyte
D. Erythrocyte
Correct Answer: C
, Rationale: B lymphocytes differentiate into plasma cells that secrete antibodies.
10. Which muscle is the main effector of inspiration?
A. Internal intercostals
B. Diaphragm
C. Abdominals
D. Sternocleidomastoid
Correct Answer: B
Rationale: The diaphragm contracts and flattens during quiet inspiration, increasing
thoracic volume.
11. Which valve closure produces the first heart sound (S1)?
A. Aortic
B. Pulmonary
C. Mitral & tricuspid
D. Mitral only
Correct Answer: C
Rationale: S1 coincides with AV valves (mitral & tricuspid) closing at onset of systole.
12. Where does fertilization normally occur?
A. Ovary
B. Fundus of uterus
C. Ampulla of fallopian tube
D. Cervix
Correct Answer: C
Rationale: Sperm meets egg in the ampulla, the lateral third of the tube.
13. Which vessel directly supplies the liver with nutrient-rich blood?
A. Hepatic artery
2026/2027 Complete Test | Anatomy, Biology, Chemistry,
Grammar, Reading, Math| Actual Questions & Verified Answers
| All Subject Areas | Pass Guarantee
SECTION 1: Anatomy & Physiology (Questions 1-40)
1. Which valve prevents back-flow of blood from the left ventricle into the left
atrium?
A. Tricuspid valve
B. Pulmonary valve
C. Mitral (bicuspid) valve
D. Aortic valve
Correct Answer: C
Rationale: The mitral (bicuspid) valve is located between the left atrium and left
ventricle and closes during ventricular systole to prevent regurgitation.
2. The primary site of nutrient absorption in the digestive tract is the:
A. Stomach
B. Duodenum
C. Ileum
D. Large intestine
Correct Answer: B
Rationale: The duodenum, the first segment of the small intestine, receives chyme and
enzymes, enabling most chemical digestion and early absorption.
, 3. Which structure carries oxygenated blood from the lungs to the heart?
A. Pulmonary artery
B. Pulmonary vein
C. Superior vena cava
D. Coronary sinus
Correct Answer: B
Rationale: Pulmonary veins are the only veins that carry oxygenated blood, returning it
from lungs to the left atrium.
4. Which hormone is released by the posterior pituitary?
A. ACTH
B. TSH
C. Oxytocin
D. Insulin
Correct Answer: C
Rationale: The posterior pituitary stores and releases oxytocin and ADH; other choices
are anterior pituitary hormones or pancreatic.
5. The functional unit of the kidney responsible for filtration is the:
A. Nephron
B. Collecting duct
C. Loop of Henle
D. Glomerulus
Correct Answer: A
Rationale: The nephron is the smallest functional unit performing filtration, reabsorption,
and secretion; glomerulus is a component.
6. Which type of joint is the shoulder?
A. Hinge
, B. Pivot
C. Ball-and-socket
D. Saddle
Correct Answer: C
Rationale: The shoulder (humerus-scapula) allows multiaxial movement typical of a
ball-and-socket joint.
7. In which layer of the skin are sebaceous glands located?
A. Stratum corneum
B. Dermis
C. Hypodermis
D. Epidermis
Correct Answer: B
Rationale: Sebaceous glands are in the dermis, often connected to hair follicles.
8. Which chamber of the heart has the thickest myocardial wall?
A. Right atrium
B. Left atrium
C. Right ventricle
D. Left ventricle
Correct Answer: D
Rationale: The left ventricle generates systemic pressure, requiring thicker muscle.
9. Which blood cell type is primarily responsible for antibody production?
A. Neutrophil
B. Monocyte
C. B lymphocyte
D. Erythrocyte
Correct Answer: C
, Rationale: B lymphocytes differentiate into plasma cells that secrete antibodies.
10. Which muscle is the main effector of inspiration?
A. Internal intercostals
B. Diaphragm
C. Abdominals
D. Sternocleidomastoid
Correct Answer: B
Rationale: The diaphragm contracts and flattens during quiet inspiration, increasing
thoracic volume.
11. Which valve closure produces the first heart sound (S1)?
A. Aortic
B. Pulmonary
C. Mitral & tricuspid
D. Mitral only
Correct Answer: C
Rationale: S1 coincides with AV valves (mitral & tricuspid) closing at onset of systole.
12. Where does fertilization normally occur?
A. Ovary
B. Fundus of uterus
C. Ampulla of fallopian tube
D. Cervix
Correct Answer: C
Rationale: Sperm meets egg in the ampulla, the lateral third of the tube.
13. Which vessel directly supplies the liver with nutrient-rich blood?
A. Hepatic artery
