ONS/ONCC CHEMOTHERAPY & IMMUNOTHERAPY CERTIFICATE 160 EXAM QUESTIONS 2026/2027 || COMPREHENSIVE ONCOLOGY NURSING CERTIFICATION EXAM PREPARATION WITH UPDATED SAFE HANDLING, ADMINISTRATION PROTOCOLS, AND ADVERSE EFFECT MANAGEMENT REVIEW || REAL ONS/ONCC EXA

ONS/ONCC CHEMOTHERAPY & IMMUNOTHERAPY
CERTIFICATE 160 EXAM QUESTIONS 2026/2027 ||
COMPREHENSIVE ONCOLOGY NURSING CERTIFICATION
EXAM PREPARATION WITH UPDATED SAFE HANDLING,
ADMINISTRATION PROTOCOLS, AND ADVERSE EFFECT
MANAGEMENT REVIEW || REAL ONS/ONCC EXAM-STYLE
QUESTIONS WITH VERIFIED DETAILED ACCURATE
ANSWERS LATEST EDITION || ELITE A+ PREMIUM QUALITY
GUARANTEED

Define mutations - THE CORRECT ANSWER - Variations in the nucleotide
sequence of a gene

3 main goals of treatment: - THE CORRECT ANSWER - Cure
Control
Palliation

Define neoadjuvant therapy - THE CORRECT ANSWER - Treatment is
given prior to surgery to shrink the tumor

Define adjuvant therapy - THE CORRECT ANSWER - Additional cancer
treatment given after the primary treatment to lower the risk that the cancer
reoccur

Define conditioning/preparative therapy - THE CORRECT ANSWER -
Treatments used to prepare a patient for stem cell transplantation

2 types of conditioning therapies: - THE CORRECT ANSWER -
Myeloablative
Nonmyeloablative

Define dose density - THE CORRECT ANSWER - Drug dose per unit of
time

Define dose intensity - THE CORRECT ANSWER - Amount of drug
delivered over time

,How is relative dose intensity (RDI) calculated? - THE CORRECT
ANSWER - By comparing the dose that the patient ACTUALLY received to
the planned dose of the standard regimen

How do alkylating agents work? - THE CORRECT ANSWER - By causing
a break in the DNA helix strand, interfering with DNA replication and causing
cell death

3 subcategories of alkylating agents: - THE CORRECT ANSWER - 1.
Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas

Most common subcategory of alkylating agents: - THE CORRECT
ANSWER - Nitrogen mustards

Common alkylating agents: - THE CORRECT ANSWER -
Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)

Common platinum-based agents: - THE CORRECT ANSWER - Cisplatin
(Platinol)
Carboplatin (Paraplatin)

What is unique about nitrosoureas agents? - THE CORRECT ANSWER -
Able to cross the blood-brain barrier; can be effective in treating some brain
tumors

Common nitrosoureas agents: - THE CORRECT ANSWER - Carmustine
(BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)

Hypersensitivity can occur with late doses of: - THE CORRECT ANSWER
- Carboplatin

These agents are typically categorized as highly emetogenic: - THE
CORRECT ANSWER - 1. Alkylating agents

, 2. Nitrosoureas

Pre-administration labs for alkylating agents and nitrosoureas: - THE
CORRECT ANSWER - BUN
Creatinine
CBC w/ diff

What is the medication Mesna used for? - THE CORRECT ANSWER -
Bladder protectant with administration of cyclophosphamide or ifosfamide

Instruct pts receiving ________ to avoid exposure to cold air and consuming cold
fluids for 3-4 days following treatment - THE CORRECT ANSWER -
Oxaliplatin

How do antimetabolites function? - THE CORRECT ANSWER - By
blocking DNA and RNA growth by interfering with enzymes needed for normal
cell metabolism

Antimetabolites work in the ___ phase. - THE CORRECT ANSWER - S

What types of cells are best affected by antimetabolites? - THE CORRECT
ANSWER - Cells with high division rates

Common side effects of antimetabolites: - THE CORRECT ANSWER -
Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome

Common antimetabolite drugs: - THE CORRECT ANSWER - Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate

The institute for Safe Medication Practices recommends what route of
administration for vincristine? - THE CORRECT ANSWER - IV piggyback
via gravity